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ENZYME

ENZYME entry: EC 2.5.1.161

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.161
Accepted Name
S-adenosyl-L-methionine:NAD(+) aminocarboxypropyltransferase
Reaction catalysed
S-adenosyl-L-methionine + NAD(+) = (4aR,7S)-2-(adenosyl(5')diphospho(5)ribosyl)-7-amino-4-carbamoyl-4a,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-7-carboxylate + S-methyl-5'-thioadenosine + 2 H(+)
Comment(s)
  • The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513, participates in the biosynthesis of the monoterpene alkaloids altemicidin, (sulfonamide-N)(L-isoleucyl)altemicidin (SB-203207) and SB-203208.
  • The enzyme catalyzes a pyridoxal phosphate-dependent [3+2]-annulation reaction between S-adenosyl-L-methionine (SAM) and NAD(+).
  • It transfers an aminocarboxypropyl group that combines with the pyridinium moiety of NAD(+) to create a pentacyclic ring, forming a 6-azatetrahydroindane scaffold.
Cross-references
BRENDA2.5.1.161
EC2PDB2.5.1.161
ExplorEnz2.5.1.161
KEGG Ligand Database for Enzyme Nomenclature2.5.1.161
IUBMB Enzyme Nomenclature2.5.1.161
MEDLINEFind literature relating to 2.5.1.161
MetaCyc2.5.1.161
Rhea expert-curated reactions2.5.1.161
UniProtKB/Swiss-Prot
P0DY52, SBZP_STRSQ

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