ID   2.5.1.161
DE   S-adenosyl-L-methionine:NAD(+) aminocarboxypropyltransferase.
CA   S-adenosyl-L-methionine + NAD(+) = (4aR,7S)-2-
CA   (adenosyl(5')diphospho(5)ribosyl)-7-amino-4-carbamoyl-4a,5,6,7-
CA   tetrahydro-2H-cyclopenta[c]pyridine-7-carboxylate + S-methyl-
CA   5'-thioadenosine + 2 H(+).
CC   -!- The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513,
CC       participates in the biosynthesis of the monoterpene alkaloids
CC       altemicidin, (sulfonamide-N)(L-isoleucyl)altemicidin (SB-203207) and
CC       SB-203208.
CC   -!- The enzyme catalyzes a pyridoxal phosphate-dependent [3+2]-annulation
CC       reaction between S-adenosyl-L-methionine (SAM) and NAD(+).
CC   -!- It transfers an aminocarboxypropyl group that combines with the
CC       pyridinium moiety of NAD(+) to create a pentacyclic ring, forming a
CC       6-azatetrahydroindane scaffold.
DR   P0DY52, SBZP_STRSQ ;
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