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ENZYME

ENZYME entry: EC 2.5.1.18

Accepted Name
glutathione transferase
Alternative Name(s)
glutathione S-alkyltransferase
glutathione S-aralkyltransferase
glutathione S-aryltransferase
S-(hydroxyalkyl)glutathione lyase
Reaction catalysed
glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)
Comment(s)
  • A group of enzymes of broad specificity.
  • R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
  • Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
  • Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
Cross-references
BRENDA2.5.1.18
EC2PDB2.5.1.18
ExplorEnz2.5.1.18
PRIAM enzyme-specific profiles2.5.1.18
KEGG Ligand Database for Enzyme Nomenclature2.5.1.18
IUBMB Enzyme Nomenclature2.5.1.18
IntEnz2.5.1.18
MEDLINEFind literature relating to 2.5.1.18
MetaCyc2.5.1.18
Rhea expert-curated reactions2.5.1.18
UniProtKB/Swiss-Prot
Q2UPB2, ACLG_ASPORQ0CS62, ATIMG_ASPTNQ9FWR4, DHAR1_ARATH
Q65XA0, DHAR1_ORYSJQ9FRL8, DHAR2_ARATHQ67UK9, DHAR2_ORYSJ
Q8LE52, DHAR3_ARATHQ9FG59, DHAR4_ARATHQ9I4K6, FOSA_PSEAE
Q56415, FOSA_SERMAA4GYZ0, GLIG_ASPFUP25373, GLRX1_YEAST
P17695, GLRX2_YEASTO77462, GST1A_ANOGAO77473, GST1B_ANOGA
Q93112, GST1C_ANOGAQ93113, GST1D_ANOGAP46436, GST1_ASCSU
O18598, GST1_BLAGEP46434, GST1_ONCVOQ9Y7Q2, GST1_SCHPO
P40582, GST1_YEASTQ9FQA3, GST23_MAIZEP30112, GST26_FASHE
P08515, GST26_SCHJAP15964, GST26_SCHMAP31670, GST27_FASHE
P35661, GST27_SCHMAP31671, GST28_FASHEP30113, GST28_SCHBO
P30114, GST28_SCHHAP26624, GST28_SCHJAP09792, GST28_SCHMA
P56598, GST29_FASHEP48429, GST2_ASCSUO16115, GST2_CAEEL
P0CG29, GST2_HUMANP46429, GST2_MANSEO59827, GST2_SCHPO
Q12390, GST2_YEASTQ09607, GST36_CAEELO16116, GST3_CAEEL
Q9P6M1, GST3_SCHPOQ21355, GST4_CAEELQ09596, GST5_CAEEL
P20137, GST5_CHICKP82607, GST67_DICLAP91252, GST6_CAEEL
P91253, GST7_CAEELP82608, GST82_DICLAP91254, GST8_CAEEL
Q21743, GST9_CAEELP80894, GSTA1_ANTSTQ28035, GSTA1_BOVIN
P81706, GSTA1_CAVPOQ08392, GSTA1_CHICKQ55FF3, GSTA1_DICDI
P08263, GSTA1_HUMANP13745, GSTA1_MOUSEP51781, GSTA1_PIG
Q08863, GSTA1_RABITP00502, GSTA1_RATO18879, GSTA2_BOVIN
Q08393, GSTA2_CHICKQ556G3, GSTA2_DICDIP09210, GSTA2_HUMAN
P10648, GSTA2_MOUSEP04903, GSTA2_RATP26697, GSTA3_CHICK
Q54VI4, GSTA3_DICDIQ16772, GSTA3_HUMANP30115, GSTA3_MOUSE
P04904, GSTA3_RATQ5E9G0, GSTA4_BOVINQ86AU1, GSTA4_DICDI
O15217, GSTA4_HUMANP24472, GSTA4_MOUSEP14942, GSTA4_RAT
Q54QV7, GSTA5_DICDIQ7RTV2, GSTA5_HUMANP46418, GSTA5_RAT
Q6AXY0, GSTA6_RATP0A9D3, GSTA_ECO57P0A9D2, GSTA_ECOLI
P30568, GSTA_PLEPLQ08862, GSTA_RABITP0ACA8, GSTB_ECOL6
P0ACA7, GSTB_ECOLIP0ACA9, GSTB_SHIFLP20432, GSTD1_DROME
Q9VG98, GSTD2_DROMEQ9VG96, GSTD4_DROMEQ9VG95, GSTD5_DROME
Q9VG94, GSTD6_DROMEQ9VG93, GSTD7_DROMEP82999, GSTE1_PSEUO
P83000, GSTE2_PSEUOQ7JYX0, GSTEE_DROMEP83001, GSTE_PSEFL
P82998, GSTE_PSEP1P82996, GSTE_PSEPUP82997, GSTE_PSEUF
P42769, GSTF1_ARATHP12653, GSTF1_MAIZEO65857, GSTF1_ORYSJ
P84983, GSTF1_POPEUP30109, GSTF1_TOBACP30110, GSTF1_WHEAT
P46422, GSTF2_ARATHO82451, GSTF2_ORYSJP84984, GSTF2_POPEU
P46440, GSTF2_TOBACP30111, GSTF2_WHEATQ9SLM6, GSTF3_ARATH
P04907, GSTF3_MAIZEQ84TK0, GSTF4_ARATHP46420, GSTF4_MAIZE
Q9SRY6, GSTF5_ARATHP42760, GSTF6_ARATHQ9SRY5, GSTF7_ARATH
Q96266, GSTF8_ARATHO80852, GSTF9_ARATHP42761, GSTFA_ARATH
Q96324, GSTFB_ARATHQ9FE46, GSTFC_ARATHQ9LZI9, GSTFD_ARATH
Q9C6C8, GSTFE_ARATHP48438, GSTF_BRAOTP46423, GSTF_HYOMU
Q04522, GSTF_SILVUQ09652, GSTK1_CAEELQ9Y2Q3, GSTK1_HUMAN
Q9DCM2, GSTK1_MOUSEP24473, GSTK1_RATQ18973, GSTK2_CAEEL
Q6NLB0, GSTL1_ARATHQ9M2W2, GSTL2_ARATHQ9LZ06, GSTL3_ARATH
Q9N0V4, GSTM1_BOVINP16413, GSTM1_CAVPOP46419, GSTM1_DERPT
P09488, GSTM1_HUMANQ9TSM5, GSTM1_MACFAP10649, GSTM1_MOUSE
P04905, GSTM1_RATP20136, GSTM2_CHICKP28161, GSTM2_HUMAN
Q9TSM4, GSTM2_MACFAQ9BEB0, GSTM2_MACFUP15626, GSTM2_MOUSE
Q5R8E8, GSTM2_PONABP08010, GSTM2_RATP21266, GSTM3_HUMAN
Q9BEA9, GSTM3_MACFUP19639, GSTM3_MOUSEQ03013, GSTM4_HUMAN
Q8R5I6, GSTM4_MOUSEQ5BK56, GSTM4_RATP46439, GSTM5_HUMAN
P86214, GSTM5_MESAUP48774, GSTM5_MOUSEQ9Z1B2, GSTM5_RAT
O35660, GSTM6_MOUSEQ80W21, GSTM7_MOUSEP08009, GSTM7_RAT
Q00285, GSTMU_CRILOP30116, GSTMU_MESAUP46409, GSTMU_RABIT
M1RIR6, GSTM_TYRPUP34345, GSTO1_CAEELP78417, GSTO1_HUMAN
O09131, GSTO1_MOUSEQ9N1F5, GSTO1_PIGQ9Z339, GSTO1_RAT
A8XT16, GSTO2_CAEBRP34277, GSTO2_CAEELQ9H4Y5, GSTO2_HUMAN
Q8K2Q2, GSTO2_MOUSEQ6AXV9, GSTO2_RATP81124, GSTO_APLCA
P28801, GSTP1_BOVINP81942, GSTP1_BUFBUP10299, GSTP1_CAEEL
Q9TTY8, GSTP1_CAPHIP46424, GSTP1_CRILOP47954, GSTP1_CRIMI
P09211, GSTP1_HUMANQ28514, GSTP1_MACMUQ60550, GSTP1_MESAU
P19157, GSTP1_MOUSEP80031, GSTP1_PIGQ5R8R5, GSTP1_PONAB
P04906, GSTP1_RATQ8JFZ2, GSTP1_XENLAP83325, GSTP2_BUFBU
P46425, GSTP2_MOUSEQ9N4X8, GSTPA_CAEELP46426, GSTP_DIRIM
P46427, GSTP_ONCVOP41043, GSTS1_DROMEQ9ZRT5, GSTT1_ARATH
Q2NL00, GSTT1_BOVINP20135, GSTT1_CHICKP30104, GSTT1_DROER
P67804, GSTT1_DROMAP30106, GSTT1_DROSEP67805, GSTT1_DROSI
P30107, GSTT1_DROTEP30108, GSTT1_DROYAP30711, GSTT1_HUMAN
P42860, GSTT1_LUCCUP46430, GSTT1_MANSEQ64471, GSTT1_MOUSE
P28338, GSTT1_MUSDOQ01579, GSTT1_RATQ94999, GSTT2_ANOGA
Q8L727, GSTT2_ARATHP0CG30, GSTT2_HUMANQ61133, GSTT2_MOUSE
P46431, GSTT2_MUSDOP30713, GSTT2_RATQ9FHE1, GSTT3_ARATH
Q99L20, GSTT3_MOUSEP46432, GSTT3_MUSDOA0A1W2PR19, GSTT4_HUMAN
Q9D4P7, GSTT4_MOUSEP46433, GSTT4_MUSDOQ4V8E6, GSTT4_RAT
O76483, GSTT7_ANOGAQ9ZW30, GSTU1_ARATHA2XMN2, GSTU1_ORYSI
Q10CE7, GSTU1_ORYSJQ9ZW29, GSTU2_ARATHQ9ZW28, GSTU3_ARATH
Q9ZW27, GSTU4_ARATHP46421, GSTU5_ARATHQ9ZW26, GSTU6_ARATH
Q06398, GSTU6_ORYSJQ9ZW24, GSTU7_ARATHQ9SR36, GSTU8_ARATH
Q9FUT0, GSTU9_ARATHQ9CA57, GSTUA_ARATHQ9CAS6, GSTUB_ARATH
Q6NMS0, GSTUC_ARATHQ9FUS6, GSTUD_ARATHQ9FUT1, GSTUE_ARATH
Q9LQ48, GSTUF_ARATHQ9XIF8, GSTUG_ARATHQ9FUS8, GSTUH_ARATH
Q9FUS9, GSTUI_ARATHQ9ZRW8, GSTUJ_ARATHQ8L7C9, GSTUK_ARATH
F4IA73, GSTUL_ARATHQ8GYM1, GSTUM_ARATHQ9M9F1, GSTUN_ARATH
Q9SHH6, GSTUO_ARATHQ9SHH7, GSTUP_ARATHQ9SHH8, GSTUQ_ARATH
Q9LZG7, GSTUR_ARATHQ9C8M3, GSTUS_ARATHP50471, GSTX1_NICPL
P32111, GSTX1_SOLTUQ03662, GSTX1_TOBACP50472, GSTX2_MAIZE
Q03663, GSTX2_TOBACP46417, GSTX3_SOYBNQ03664, GSTX3_TOBAC
Q03666, GSTX4_TOBACP32110, GSTX6_SOYBNP25317, GSTXA_TOBAC
P49332, GSTXC_TOBACP30102, GSTY2_PICKUQ9ZVQ3, GSTZ1_ARATH
P28342, GSTZ1_DIACAQ9ZVQ4, GSTZ2_ARATHQ03425, GSTZ2_DIACA
P57108, GSTZ_EUPESO04437, GSTZ_WHEATQ6R4B4, GST_ALTAL
P46428, GST_ANOGAP83246, GST_ASADIP81065, GST_BRUAN
D2YW48, GST_COCIMP44521, GST_HAEINC0HLL7, GST_LACPN
P46437, GST_MUSDOP46088, GST_NOTSLQ8ILQ7, GST_PLAF7
Q0ZS46, GST_PLAVIQ7REH6, GST_PLAYOP15214, GST_PROMI
P22416, GST_SERMAP45875, GST_XANCPP48239, GTO1_YEAST
O94524, GTO2_SCHPOP36156, GTO2_YEASTQ04806, GTO3_YEAST
O73888, HPGDS_CHICKO60760, HPGDS_HUMANQ9JHF7, HPGDS_MOUSE
O35543, HPGDS_RATB3FWR8, HPM2_HYPSBF1MVX2, LANC1_BOVIN
Q90ZL2, LANC1_DANREO43813, LANC1_HUMANO89112, LANC1_MOUSE
Q9QX69, LANC1_RATQ9VHD3, MAAI1_DROMEQ9VHD2, MAAI2_DROME
O43708, MAAI_HUMANQ9WVL0, MAAI_MOUSEP57113, MAAI_RAT
Q64L89, MGST1_BOVINP10620, MGST1_HUMANQ91VS7, MGST1_MOUSE
P79382, MGST1_PIGP08011, MGST1_RATQ2KJG4, MGST2_BOVIN
Q99735, MGST2_HUMANA2RST1, MGST2_MOUSEQ54GA9, MGST_DICDI
Q95L14, PTGES_BOVINA0SYQ0, PTGES_CANLFQ8HZJ2, PTGES_HORSE
O14684, PTGES_HUMANQ6PWL6, PTGES_MACFAQ9JM51, PTGES_MOUSE
Q9JHF3, PTGES_RATQ6Q882, SIRG_LEPMCO80662, TCHQD_ARATH
M1W426, TCPG_CLAP2A0A1U9YI21, VERG_CLOROO74830, YC12_SCHPO
P77544, YFCF_ECOLIB5BP46, YP52_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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