Due to maintenance work, this service and ftp://ftp.expasy.org will be unavailable from Tuesday August 23rd 18:00 until Wednesday August 24th 08:00
CEST. Apologies for the inconvenience.
ENZYME entry: EC 2.5.1.25
| Accepted Name |
|---|
| tRNA-uridine aminocarboxypropyltransferase.
|
| Reaction catalysed |
|---|
| a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine |
| Comment(s) |
|---|
- 3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved
modification found in tRNA core region in bacteria and eukaryotes
that confers thermal stability on tRNA.
- The enzyme from the bacterium Escherichia coli catalyzes the
modification of uridine(47) in the V-loop of tRNAs for Arg(2),
Ile(1), Ile(2), Ile(2)v, Lys, Met, Phe, Val(2)A, and Val(2)B.
- The human homologs DTWD1 and DTWD2 are responsible for acp3U
formation at positions 20 and 20a, respectively, in the D-loop of
several cytoplasmic tRNAs.
|
| Cross-references |
|---|
| BRENDA | 2.5.1.25 |
| EC2PDB | 2.5.1.25 |
| ExplorEnz | 2.5.1.25 |
| PRIAM enzyme-specific profiles | 2.5.1.25 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.25 |
| IUBMB Enzyme Nomenclature | 2.5.1.25 |
| IntEnz | 2.5.1.25 |
| MEDLINE | Find literature relating to 2.5.1.25 |
| MetaCyc | 2.5.1.25 |
| Rhea expert-curated reactions | 2.5.1.25 |
| UniProtKB/Swiss-Prot |
| Q5XJ56, DTWD1_DANRE; | Q8N5C7, DTWD1_HUMAN; | Q9D8U7, DTWD1_MOUSE; |
| Q5RCQ0, DTWD1_PONAB; | Q6AYF5, DTWD1_RAT; | Q6DDV1, DTWD1_XENLA; |
| Q28I29, DTWD1_XENTR; | Q8NBA8, DTWD2_HUMAN; | Q4R7M4, DTWD2_MACFA; |
| Q9D0U1, DTWD2_MOUSE; | Q47319, TAPT_ECOLI; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-