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ENZYME

ENZYME entry: EC 2.5.1.25

Accepted Name
tRNA-uridine aminocarboxypropyltransferase
Reaction catalysed
a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine
Comment(s)
  • 3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved modification found in tRNA core region in bacteria and eukaryotes that confers thermal stability on tRNA.
  • The enzyme from the bacterium Escherichia coli catalyzes the modification of uridine(47) in the V-loop of tRNAs for Arg(2), Ile(1), Ile(2), Ile(2)v, Lys, Met, Phe, Val(2)A, and Val(2)B.
  • The human homologs DTWD1 and DTWD2 are responsible for acp3U formation at positions 20 and 20a, respectively, in the D-loop of several cytoplasmic tRNAs.
Cross-references
BRENDA2.5.1.25
EC2PDB2.5.1.25
ExplorEnz2.5.1.25
PRIAM enzyme-specific profiles2.5.1.25
KEGG Ligand Database for Enzyme Nomenclature2.5.1.25
IUBMB Enzyme Nomenclature2.5.1.25
IntEnz2.5.1.25
MEDLINEFind literature relating to 2.5.1.25
MetaCyc2.5.1.25
Rhea expert-curated reactions2.5.1.25
UniProtKB/Swiss-Prot
F4IL05, DTW2A_ARATHQ5XJ56, DTWD1_DANREQ8N5C7, DTWD1_HUMAN
Q9D8U7, DTWD1_MOUSEQ5RCQ0, DTWD1_PONABQ6AYF5, DTWD1_RAT
Q6DDV1, DTWD1_XENLAQ28I29, DTWD1_XENTRQ9VI85, DTWD2_DROME
Q8NBA8, DTWD2_HUMANQ4R7M4, DTWD2_MACFAQ9D0U1, DTWD2_MOUSE
Q47319, TAPT_ECOLI

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