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ENZYME entry: EC 2.5.1.25

Accepted Name
tRNA-uridine aminocarboxypropyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a uridine in tRNA <=> S-methyl-5'-thioadenosine + a 3-((3S)-3-amino-3-carboxypropyl)uridine in tRNA
Comment(s)
  • 3-((3S)-3-amino-3-carboxypropyl)uridine (acp3U) is a highly conserved modification found in tRNA core region in bacteria and eukaryotes that confers thermal stability on tRNA.
  • The enzyme from the bacterium Escherichia coli catalyzes the modification of uridine(47) in the V-loop of tRNAs for Arg(2), Ile(1), Ile(2), Ile(2)v, Lys, Met, Phe, Val(2)A, and Val(2)B.
  • The human homologs DTWD1 and DTWD2 are responsible for acp3U formation at positions 20 and 20a, respectively, in the D-loop of several cytoplasmic tRNAs.
Cross-references
BRENDA2.5.1.25
EC2PDB2.5.1.25
ExplorEnz2.5.1.25
PRIAM enzyme-specific profiles2.5.1.25
KEGG Ligand Database for Enzyme Nomenclature2.5.1.25
IUBMB Enzyme Nomenclature2.5.1.25
IntEnz2.5.1.25
MEDLINEFind literature relating to 2.5.1.25
MetaCyc2.5.1.25
Rhea expert-curated reactions2.5.1.25
UniProtKB/Swiss-Prot
Q5XJ56, DTWD1_DANRE;  Q8N5C7, DTWD1_HUMAN;  Q9D8U7, DTWD1_MOUSE;  
Q5RCQ0, DTWD1_PONAB;  Q6AYF5, DTWD1_RAT;  Q6DDV1, DTWD1_XENLA;  
Q28I29, DTWD1_XENTR;  Q8NBA8, DTWD2_HUMAN;  Q4R7M4, DTWD2_MACFA;  
Q9D0U1, DTWD2_MOUSE;  Q47319, TAPT_ECOLI;  

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