ID 2.5.1.3 DE thiamine phosphate synthase. AN thiamine-phosphate diphosphorylase. AN thiamine-phosphate pyrophosphorylase. AN thiamine-phosphate synthase. AN TMP diphosphorylase. AN TMP pyrophosphorylase. CA (1) 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + CA 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + CA diphosphate + thiamine phosphate. CA (2) 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl- CA 5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine CA phosphate. CA (3) 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5- CA (2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate. CC -!- The enzyme catalyzes the penultimate reaction in thiamine de novo CC biosynthesis, condensing the pyrimidine and thiazole components. CC -!- The enzyme is thought to accept the product of EC 2.8.1.10 as its CC substrate. CC -!- However, it has been shown that in some bacteria, such as Bacillus CC subtilis, an additional enzyme, EC 5.3.99.10 converts that compound CC into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, CC and that it is the latter that serves as the substrate for the CC synthase. CC -!- In addition to this activity, the enzyme participates in a salvage CC pathway, acting on 4-methyl-5-(2-phosphono-oxyethyl)thiazole, which CC is produced from thiamine degradation products. CC -!- In yeast this activity is found in a bifunctional enzyme and in the CC plant Arabidopsis thaliana the activity is part of a trifunctional CC enzyme. DR P40386, THI6_SCHPO ; P41835, THI6_YEAST ; Q57688, THIDN_METJA; DR Q9WZP7, THIDN_THEMA; O66833, THIE1_AQUAE; Q97RS5, THIE1_STRPN; DR Q8DQK4, THIE1_STRR6; O67378, THIE2_AQUAE; P66920, THIE2_STRPN; DR P66921, THIE2_STRR6; Q8G7X1, THIEC_BIFLO; Q8FTH8, THIED_COREF; DR Q8NQH1, THIED_CORGL; P61422, THIED_GEOSL; A0LTK3, THIE_ACIC1 ; DR B7JBI2, THIE_ACIF2 ; B5ERP0, THIE_ACIF5 ; B3GX82, THIE_ACTP7 ; DR A6VPG9, THIE_ACTSZ ; Q8UAS8, THIE_AGRFC ; Q21VL5, THIE_ALBFT ; DR Q0VSP5, THIE_ALCBS ; Q5WH87, THIE_ALKCK ; A6TMN5, THIE_ALKMQ ; DR A8MK92, THIE_ALKOO ; Q2IM25, THIE_ANADE ; B7GKQ8, THIE_ANOFW ; DR O28205, THIE_ARCFU ; Q5P6J5, THIE_AROAE ; A0JYP1, THIE_ARTS2 ; DR A8IGE6, THIE_AZOC5 ; A1KB60, THIE_AZOSB ; C1DMY6, THIE_AZOVD ; DR C3PBW1, THIE_BACAA ; C3L627, THIE_BACAC ; A0R981, THIE_BACAH ; DR Q81Z95, THIE_BACAN ; B7JN72, THIE_BACC0 ; P61410, THIE_BACC1 ; DR C1EVE6, THIE_BACC3 ; B7H7H5, THIE_BACC4 ; B7HT70, THIE_BACC7 ; DR A7GKR4, THIE_BACCN ; B9J2L5, THIE_BACCQ ; Q81IG8, THIE_BACCR ; DR Q63GK3, THIE_BACCZ ; Q5LCA7, THIE_BACFN ; Q64TA1, THIE_BACFR ; DR Q6HP17, THIE_BACHK ; Q65DK0, THIE_BACLD ; A9VRN4, THIE_BACMK ; DR A8FIR6, THIE_BACP2 ; P39594, THIE_BACSU ; Q8AA13, THIE_BACTN ; DR A7ZA58, THIE_BACVZ ; Q2KUS6, THIE_BORA1 ; Q7WF72, THIE_BORBR ; DR Q7W3U2, THIE_BORPA ; Q7W049, THIE_BORPE ; B9MN52, THIE_CALBD ; DR A8M9N4, THIE_CALMQ ; Q8R806, THIE_CALS4 ; A4XG66, THIE_CALS8 ; DR A8FMD4, THIE_CAMJ8 ; Q9PNL3, THIE_CAMJE ; A1W068, THIE_CAMJJ ; DR Q5HU23, THIE_CAMJR ; B0SUK3, THIE_CAUSK ; A9WDL8, THIE_CHLAA ; DR Q5L6R5, THIE_CHLAB ; Q824E9, THIE_CHLCV ; B3ED41, THIE_CHLL2 ; DR Q3B4B1, THIE_CHLL3 ; B3QNM2, THIE_CHLP8 ; A1BGM7, THIE_CHLPD ; DR A4SEP8, THIE_CHLPM ; Q8KD79, THIE_CHLTE ; Q7P1R3, THIE_CHRVO ; DR A8AKT0, THIE_CITK8 ; Q97LQ9, THIE_CLOAB ; A7FPT0, THIE_CLOB1 ; DR C3L061, THIE_CLOB6 ; A6M1W6, THIE_CLOB8 ; B2UY65, THIE_CLOBA ; DR B2TQ13, THIE_CLOBB ; A5HYZ3, THIE_CLOBH ; C1FSC1, THIE_CLOBJ ; DR B1IEG6, THIE_CLOBK ; A7GAL0, THIE_CLOBL ; B1KV12, THIE_CLOBM ; DR Q186F8, THIE_CLOD6 ; A0Q2A0, THIE_CLONN ; Q0TQV4, THIE_CLOP1 ; DR Q8XKQ8, THIE_CLOPE ; Q0STA1, THIE_CLOPS ; Q893R0, THIE_CLOTE ; DR B5Y6I1, THIE_COPPD ; Q8FP55, THIE_COREF ; Q4JVZ1, THIE_CORJK ; DR A7MJ80, THIE_CROS8 ; Q478V2, THIE_DECAR ; Q1IX16, THIE_DEIGD ; DR Q9RYX9, THIE_DEIRA ; B8FUD4, THIE_DESHD ; Q24XQ0, THIE_DESHY ; DR B5YA97, THIE_DICT6 ; B8E358, THIE_DICTD ; A7ZUK8, THIE_ECO24 ; DR Q8X6Y0, THIE_ECO57 ; B5Z089, THIE_ECO5E ; A8A793, THIE_ECOHS ; DR A1AIG4, THIE_ECOK1 ; Q0TA72, THIE_ECOL5 ; Q8FB78, THIE_ECOL6 ; DR B1IUQ4, THIE_ECOLC ; P30137, THIE_ECOLI ; B6I5K4, THIE_ECOSE ; DR Q1R5V9, THIE_ECOUT ; A4W5B6, THIE_ENT38 ; Q830K5, THIE_ENTFA ; DR Q2NB00, THIE_ERYLH ; A5FJJ1, THIE_FLAJ1 ; A6GWR9, THIE_FLAPJ ; DR Q8RI59, THIE_FUSNN ; Q5KZU0, THIE_GEOKA ; P61411, THIE_GEOSL ; DR A4IN28, THIE_GEOTN ; Q7NNK8, THIE_GLOVI ; Q4QNC6, THIE_HAEI8 ; DR A5UA71, THIE_HAEIE ; A5UGT0, THIE_HAEIG ; P71350, THIE_HAEIN ; DR Q0I131, THIE_HAES1 ; Q9KCY8, THIE_HALH5 ; A1WYL4, THIE_HALHL ; DR Q5V0G6, THIE_HALMA ; Q18GX9, THIE_HALWD ; Q1CT27, THIE_HELPH ; DR Q9ZL01, THIE_HELPJ ; B2USY5, THIE_HELPS ; O25514, THIE_HELPY ; DR A9AZD9, THIE_HERA2 ; B4U6B2, THIE_HYDS0 ; Q0BXD3, THIE_HYPNA ; DR A6SUR1, THIE_JANMA ; A6W6A2, THIE_KINRD ; A6TGQ0, THIE_KLEP7 ; DR Q1ILG3, THIE_KORVE ; B3W783, THIE_LACCB ; Q9CG48, THIE_LACLA ; DR A2RKJ7, THIE_LACLM ; Q02YS6, THIE_LACLS ; Q03CB2, THIE_LACP3 ; DR Q890C0, THIE_LACPL ; C1DCM3, THIE_LARHH ; Q38ZM1, THIE_LATSS ; DR Q1MRJ6, THIE_LAWIP ; B0SE83, THIE_LEPBA ; B0SMR9, THIE_LEPBP ; DR B1MX63, THIE_LEUCK ; Q03NS1, THIE_LEVBA ; B2GBV5, THIE_LIMF3 ; DR A5VKA1, THIE_LIMRD ; B2G7Q4, THIE_LIMRJ ; Q92EW5, THIE_LISIN ; DR C1KZ34, THIE_LISMC ; Q723Y9, THIE_LISMF ; B8DET0, THIE_LISMH ; DR Q8YA44, THIE_LISMO ; A0AFC5, THIE_LISW6 ; B1HX34, THIE_LYSSC ; DR Q65US7, THIE_MANSM ; A1TYG6, THIE_MARN8 ; Q8TMD6, THIE_METAC ; DR Q0W1L8, THIE_METAR ; A7IA09, THIE_METB6 ; Q466J5, THIE_METBF ; DR Q602R3, THIE_METCA ; Q1GXW1, THIE_METFK ; Q2FM63, THIE_METHJ ; DR A4FX32, THIE_METM5 ; A9AAG9, THIE_METM6 ; A6VG83, THIE_METM7 ; DR Q8PS49, THIE_METMA ; A3CS45, THIE_METMJ ; P61413, THIE_METMP ; DR A5ULP4, THIE_METS3 ; A6UPE6, THIE_METVS ; Q2RGI8, THIE_MOOTA ; DR A0QLT6, THIE_MYCA1 ; P66917, THIE_MYCBO ; A1KFN6, THIE_MYCBP ; DR A4T2R5, THIE_MYCGI ; B8ZU95, THIE_MYCLB ; Q9ZBL5, THIE_MYCLE ; DR B2HPZ9, THIE_MYCMM ; P61412, THIE_MYCPA ; A0QQK7, THIE_MYCS2 ; DR A3PTW9, THIE_MYCSJ ; A1UAB4, THIE_MYCSK ; Q1BEL9, THIE_MYCSS ; DR A5TZE0, THIE_MYCTA ; P9WG74, THIE_MYCTO ; P9WG75, THIE_MYCTU ; DR A0PRY2, THIE_MYCUA ; A1T2Z5, THIE_MYCVP ; Q1D282, THIE_MYXXD ; DR Q3IP34, THIE_NATPD ; Q5F5C2, THIE_NEIG1 ; Q9JWI2, THIE_NEIMA ; DR Q9JXF7, THIE_NEIMB ; Q0AFV0, THIE_NITEC ; Q82UQ7, THIE_NITEU ; DR Q2Y5Q6, THIE_NITMU ; Q3JDH3, THIE_NITOC ; Q5YNP9, THIE_NOCFA ; DR B2J6F7, THIE_NOSP7 ; Q8YX72, THIE_NOSS1 ; Q8ESZ3, THIE_OCEIH ; DR Q7U5U1, THIE_PARMW ; P57930, THIE_PASMU ; Q6DAM1, THIE_PECAS ; DR Q03GM4, THIE_PEDPA ; A5D4K4, THIE_PELTS ; Q4FN35, THIE_PELUB ; DR C0QR82, THIE_PERMH ; Q7N964, THIE_PHOLL ; A6L645, THIE_PHOV8 ; DR Q6KZH9, THIE_PICTO ; A2CB21, THIE_PROM3 ; Q7VAV5, THIE_PROMA ; DR B4EYU2, THIE_PROMH ; Q7V8I3, THIE_PROMM ; Q7V0I3, THIE_PROMP ; DR A2BSJ5, THIE_PROMS ; Q48DP2, THIE_PSE14 ; A6V0D3, THIE_PSEA7 ; DR B7V9E0, THIE_PSEA8 ; Q02SE4, THIE_PSEAB ; Q9HX40, THIE_PSEAE ; DR Q1I4H6, THIE_PSEE4 ; Q4K5I7, THIE_PSEF5 ; C3K2K2, THIE_PSEFS ; DR A4XYV5, THIE_PSEMY ; A5W9G9, THIE_PSEP1 ; Q3K6C1, THIE_PSEPF ; DR B0KJV8, THIE_PSEPG ; Q88DP1, THIE_PSEPK ; B1J1Y7, THIE_PSEPW ; DR Q87VY6, THIE_PSESM ; Q4ZNA1, THIE_PSEU2 ; A4VQX9, THIE_PSEU5 ; DR A5WDP0, THIE_PSYWF ; Q9UZQ5, THIE_PYRAB ; Q8U192, THIE_PYRFU ; DR O58878, THIE_PYRHO ; O34294, THIE_RHIEC ; Q7UQH1, THIE_RHOBA ; DR B6INN5, THIE_RHOCS ; A7NRF7, THIE_ROSCS ; A5UUL3, THIE_ROSS1 ; DR B8I3J4, THIE_RUMCH ; Q21MI9, THIE_SACD2 ; A4F727, THIE_SACEN ; DR B5F1H6, THIE_SALA4 ; A8M4E6, THIE_SALAI ; A9MHD7, THIE_SALAR ; DR Q57H62, THIE_SALCH ; B5FQK8, THIE_SALDC ; B5QYE8, THIE_SALEP ; DR B5RFJ1, THIE_SALG2 ; B4TCT2, THIE_SALHS ; B4T0Z5, THIE_SALNS ; DR Q5PKA7, THIE_SALPA ; A9N0K5, THIE_SALPB ; B5BJR2, THIE_SALPK ; DR Q2S2A8, THIE_SALRD ; B4TQK3, THIE_SALSV ; Q8Z325, THIE_SALTI ; DR A4XBL2, THIE_SALTO ; Q9L9I8, THIE_SALTY ; A8G8F3, THIE_SERP5 ; DR B2TWI0, THIE_SHIB3 ; Q31U04, THIE_SHIBS ; Q32AG6, THIE_SHIDS ; DR Q0SY07, THIE_SHIF8 ; Q83PB9, THIE_SHIFL ; Q3YUZ1, THIE_SHISS ; DR C4XIJ2, THIE_SOLM1 ; A7X4S8, THIE_STAA1 ; A6U3H7, THIE_STAA2 ; DR Q2FF35, THIE_STAA3 ; Q2FWG3, THIE_STAA8 ; A5IUN7, THIE_STAA9 ; DR Q2YUL2, THIE_STAAB ; Q5HEA8, THIE_STAAC ; A6QIT5, THIE_STAAE ; DR P66918, THIE_STAAM ; P66919, THIE_STAAN ; Q6GEY4, THIE_STAAR ; DR Q6G7L9, THIE_STAAS ; Q8NVH5, THIE_STAAW ; Q9RGS5, THIE_STACT ; DR Q5HMD0, THIE_STAEQ ; Q8CNK2, THIE_STAES ; Q4L7X3, THIE_STAHJ ; DR Q49Z39, THIE_STAS1 ; Q3K1L6, THIE_STRA1 ; Q8E5W9, THIE_STRA3 ; DR Q8E092, THIE_STRA5 ; Q82AF9, THIE_STRAW ; Q9S2V2, THIE_STRCO ; DR A4W0K4, THIE_STRS2 ; A5GMH7, THIE_SYNPW ; Q0IC17, THIE_SYNS3 ; DR Q3AL68, THIE_SYNSC ; Q0AZ86, THIE_SYNWW ; P72965, THIE_SYNY3 ; DR Q9HIQ4, THIE_THEAC ; Q47R33, THIE_THEFY ; Q72KL8, THIE_THET2 ; DR Q5SKG9, THIE_THET8 ; Q8DHK2, THIE_THEVB ; Q97BE8, THIE_THEVO ; DR Q3SFU7, THIE_THIDA ; B8GLE3, THIE_THISH ; A7N7S3, THIE_VIBC1 ; DR Q87JW8, THIE_VIBPA ; Q7M9N9, THIE_WOLSU ; Q8PH45, THIE_XANAC ; DR Q4UYA4, THIE_XANC8 ; Q8P5R7, THIE_XANCP ; A7IGG9, THIE_XANP2 ; DR Q9PGC4, THIE_XYLFA ; Q87AX6, THIE_XYLFT ; A7FNH7, THIE_YERP3 ; DR Q1C1U8, THIE_YERPA ; Q8ZAQ1, THIE_YERPE ; Q1CN71, THIE_YERPN ; DR A4TS25, THIE_YERPP ; Q66FP6, THIE_YERPS ; Q67T51, THIME_SYMTH; DR O26949, THIN_METTH ; Q5M731, TPS1L_ARATH; O48881, TPS1_BRANA ; DR Q2QWK9, TPS1_ORYSJ ; //