ID   2.5.1.3
DE   Thiamine phosphate synthase.
AN   Thiamine-phosphate diphosphorylase.
AN   Thiamine-phosphate pyrophosphorylase.
AN   Thiamine-phosphate synthase.
AN   TMP diphosphorylase.
AN   TMP pyrophosphorylase.
CA   (1) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy-
CA   4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine
CA   phosphate + CO(2).
CA   (2) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-(2-carboxy-4-
CA   methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate +
CA   CO(2).
CA   (3) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-
CA   (2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.
CC   -!- The enzyme catalyzes the penultimate reaction in thiamine de novo
CC       biosynthesis, condensing the pyrimidine and thiazole components.
CC   -!- The enzyme is thought to accept the product of EC 2.8.1.10 as its
CC       substrate.
CC   -!- However, it has been shown that in some bacteria, such as Bacillus
CC       subtilis, an additional enzyme, EC 5.3.99.10 converts that compound
CC       into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate,
CC       and that it is the latter that serves as the substrate for the
CC       synthase.
CC   -!- In addition to this activity, the enzyme participates in a salvage
CC       pathway, acting on 4-methyl-5-(2-phosphono-oxyethyl)thiazole, which
CC       is produced from thiamine degradation products.
CC   -!- In yeast this activity is found in a bifunctional enzyme and in the
CC       plant Arabidopsis thaliana the activity is part of a trifunctional
CC       enzyme.
DR   P40386, THI6_SCHPO ;  P41835, THI6_YEAST ;  Q57688, THIDN_METJA;
DR   Q9WZP7, THIDN_THEMA;  O66833, THIE1_AQUAE;  Q97RS5, THIE1_STRPN;
DR   Q8DQK4, THIE1_STRR6;  O67378, THIE2_AQUAE;  P66920, THIE2_STRPN;
DR   P66921, THIE2_STRR6;  Q8G7X1, THIEC_BIFLO;  Q8FTH8, THIED_COREF;
DR   Q8NQH1, THIED_CORGL;  P61422, THIED_GEOSL;  A0LTK3, THIE_ACIC1 ;
DR   B7JBI2, THIE_ACIF2 ;  B5ERP0, THIE_ACIF5 ;  B3GX82, THIE_ACTP7 ;
DR   A6VPG9, THIE_ACTSZ ;  Q8UAS8, THIE_AGRFC ;  Q0VSP5, THIE_ALCBS ;
DR   A6TMN5, THIE_ALKMQ ;  A8MK92, THIE_ALKOO ;  Q2IM25, THIE_ANADE ;
DR   B7GKQ8, THIE_ANOFW ;  O28205, THIE_ARCFU ;  Q5P6J5, THIE_AROAE ;
DR   A0JYP1, THIE_ARTS2 ;  A8IGE6, THIE_AZOC5 ;  A1KB60, THIE_AZOSB ;
DR   C1DMY6, THIE_AZOVD ;  C3PBW1, THIE_BACAA ;  C3L627, THIE_BACAC ;
DR   A0R981, THIE_BACAH ;  Q81Z95, THIE_BACAN ;  B7JN72, THIE_BACC0 ;
DR   P61410, THIE_BACC1 ;  C1EVE6, THIE_BACC3 ;  B7H7H5, THIE_BACC4 ;
DR   B7HT70, THIE_BACC7 ;  A7GKR4, THIE_BACCN ;  B9J2L5, THIE_BACCQ ;
DR   Q81IG8, THIE_BACCR ;  Q63GK3, THIE_BACCZ ;  Q5LCA7, THIE_BACFN ;
DR   Q64TA1, THIE_BACFR ;  Q9KCY8, THIE_BACHD ;  Q6HP17, THIE_BACHK ;
DR   Q65DK0, THIE_BACLD ;  A9VRN4, THIE_BACMK ;  A8FIR6, THIE_BACP2 ;
DR   Q5WH87, THIE_BACSK ;  P39594, THIE_BACSU ;  Q8AA13, THIE_BACTN ;
DR   A6L645, THIE_BACV8 ;  A7ZA58, THIE_BACVZ ;  Q2KUS6, THIE_BORA1 ;
DR   Q7WF72, THIE_BORBR ;  Q7W3U2, THIE_BORPA ;  Q7W049, THIE_BORPE ;
DR   B9MN52, THIE_CALBD ;  A8M9N4, THIE_CALMQ ;  Q8R806, THIE_CALS4 ;
DR   A4XG66, THIE_CALS8 ;  A8FMD4, THIE_CAMJ8 ;  Q9PNL3, THIE_CAMJE ;
DR   A1W068, THIE_CAMJJ ;  Q5HU23, THIE_CAMJR ;  B0SUK3, THIE_CAUSK ;
DR   A9WDL8, THIE_CHLAA ;  Q5L6R5, THIE_CHLAB ;  Q824E9, THIE_CHLCV ;
DR   B3ED41, THIE_CHLL2 ;  B3QNM2, THIE_CHLP8 ;  A1BGM7, THIE_CHLPD ;
DR   A4SEP8, THIE_CHLPM ;  Q8KD79, THIE_CHLTE ;  Q7P1R3, THIE_CHRVO ;
DR   A8AKT0, THIE_CITK8 ;  Q97LQ9, THIE_CLOAB ;  A7FPT0, THIE_CLOB1 ;
DR   C3L061, THIE_CLOB6 ;  A6M1W6, THIE_CLOB8 ;  B2UY65, THIE_CLOBA ;
DR   B2TQ13, THIE_CLOBB ;  A5HYZ3, THIE_CLOBH ;  C1FSC1, THIE_CLOBJ ;
DR   B1IEG6, THIE_CLOBK ;  A7GAL0, THIE_CLOBL ;  B1KV12, THIE_CLOBM ;
DR   Q186F8, THIE_CLOD6 ;  A0Q2A0, THIE_CLONN ;  Q0TQV4, THIE_CLOP1 ;
DR   Q8XKQ8, THIE_CLOPE ;  Q0STA1, THIE_CLOPS ;  Q893R0, THIE_CLOTE ;
DR   B5Y6I1, THIE_COPPD ;  Q8FP55, THIE_COREF ;  Q4JVZ1, THIE_CORJK ;
DR   A7MJ80, THIE_CROS8 ;  Q478V2, THIE_DECAR ;  Q1IX16, THIE_DEIGD ;
DR   Q9RYX9, THIE_DEIRA ;  B8FUD4, THIE_DESHD ;  Q24XQ0, THIE_DESHY ;
DR   C4XIJ2, THIE_DESMR ;  B5YA97, THIE_DICT6 ;  B8E358, THIE_DICTD ;
DR   A7ZUK8, THIE_ECO24 ;  Q8X6Y0, THIE_ECO57 ;  B5Z089, THIE_ECO5E ;
DR   A8A793, THIE_ECOHS ;  A1AIG4, THIE_ECOK1 ;  Q0TA72, THIE_ECOL5 ;
DR   Q8FB78, THIE_ECOL6 ;  B1IUQ4, THIE_ECOLC ;  P30137, THIE_ECOLI ;
DR   B6I5K4, THIE_ECOSE ;  Q1R5V9, THIE_ECOUT ;  A4W5B6, THIE_ENT38 ;
DR   Q830K5, THIE_ENTFA ;  Q2NB00, THIE_ERYLH ;  A5FJJ1, THIE_FLAJ1 ;
DR   A6GWR9, THIE_FLAPJ ;  Q8RI59, THIE_FUSNN ;  Q5KZU0, THIE_GEOKA ;
DR   P61411, THIE_GEOSL ;  A4IN28, THIE_GEOTN ;  Q7NNK8, THIE_GLOVI ;
DR   Q4QNC6, THIE_HAEI8 ;  A5UA71, THIE_HAEIE ;  A5UGT0, THIE_HAEIG ;
DR   P71350, THIE_HAEIN ;  Q0I131, THIE_HAES1 ;  A1WYL4, THIE_HALHL ;
DR   Q5V0G6, THIE_HALMA ;  Q18GX9, THIE_HALWD ;  Q1CT27, THIE_HELPH ;
DR   Q9ZL01, THIE_HELPJ ;  B2USY5, THIE_HELPS ;  O25514, THIE_HELPY ;
DR   A9AZD9, THIE_HERA2 ;  B4U6B2, THIE_HYDS0 ;  Q0BXD3, THIE_HYPNA ;
DR   A6SUR1, THIE_JANMA ;  A6W6A2, THIE_KINRD ;  A6TGQ0, THIE_KLEP7 ;
DR   Q1ILG3, THIE_KORVE ;  Q03NS1, THIE_LACBA ;  B3W783, THIE_LACCB ;
DR   B2GBV5, THIE_LACF3 ;  Q9CG48, THIE_LACLA ;  A2RKJ7, THIE_LACLM ;
DR   Q02YS6, THIE_LACLS ;  Q03CB2, THIE_LACP3 ;  Q890C0, THIE_LACPL ;
DR   A5VKA1, THIE_LACRD ;  B2G7Q4, THIE_LACRJ ;  Q38ZM1, THIE_LACSS ;
DR   C1DCM3, THIE_LARHH ;  Q1MRJ6, THIE_LAWIP ;  B0SE83, THIE_LEPBA ;
DR   B0SMR9, THIE_LEPBP ;  B1MX63, THIE_LEUCK ;  Q92EW5, THIE_LISIN ;
DR   C1KZ34, THIE_LISMC ;  Q723Y9, THIE_LISMF ;  B8DET0, THIE_LISMH ;
DR   Q8YA44, THIE_LISMO ;  A0AFC5, THIE_LISW6 ;  B1HX34, THIE_LYSSC ;
DR   Q65US7, THIE_MANSM ;  A1TYG6, THIE_MARHV ;  Q8TMD6, THIE_METAC ;
DR   Q0W1L8, THIE_METAR ;  A7IA09, THIE_METB6 ;  Q466J5, THIE_METBF ;
DR   Q602R3, THIE_METCA ;  Q1GXW1, THIE_METFK ;  Q2FM63, THIE_METHJ ;
DR   A4FX32, THIE_METM5 ;  A9AAG9, THIE_METM6 ;  A6VG83, THIE_METM7 ;
DR   Q8PS49, THIE_METMA ;  A3CS45, THIE_METMJ ;  P61413, THIE_METMP ;
DR   A5ULP4, THIE_METS3 ;  A6UPE6, THIE_METVS ;  Q2RGI8, THIE_MOOTA ;
DR   A0QLT6, THIE_MYCA1 ;  P66917, THIE_MYCBO ;  A1KFN6, THIE_MYCBP ;
DR   A4T2R5, THIE_MYCGI ;  B8ZU95, THIE_MYCLB ;  Q9ZBL5, THIE_MYCLE ;
DR   B2HPZ9, THIE_MYCMM ;  P61412, THIE_MYCPA ;  A0QQK7, THIE_MYCS2 ;
DR   A3PTW9, THIE_MYCSJ ;  A1UAB4, THIE_MYCSK ;  Q1BEL9, THIE_MYCSS ;
DR   A5TZE0, THIE_MYCTA ;  P9WG74, THIE_MYCTO ;  P9WG75, THIE_MYCTU ;
DR   A0PRY2, THIE_MYCUA ;  A1T2Z5, THIE_MYCVP ;  Q1D282, THIE_MYXXD ;
DR   Q3IP34, THIE_NATPD ;  Q5F5C2, THIE_NEIG1 ;  Q9JWI2, THIE_NEIMA ;
DR   Q9JXF7, THIE_NEIMB ;  Q0AFV0, THIE_NITEC ;  Q82UQ7, THIE_NITEU ;
DR   Q2Y5Q6, THIE_NITMU ;  Q3JDH3, THIE_NITOC ;  Q5YNP9, THIE_NOCFA ;
DR   B2J6F7, THIE_NOSP7 ;  Q8YX72, THIE_NOSS1 ;  Q8ESZ3, THIE_OCEIH ;
DR   P57930, THIE_PASMU ;  Q6DAM1, THIE_PECAS ;  Q03GM4, THIE_PEDPA ;
DR   Q3B4B1, THIE_PELLD ;  A5D4K4, THIE_PELTS ;  Q4FN35, THIE_PELUB ;
DR   C0QR82, THIE_PERMH ;  Q7N964, THIE_PHOLL ;  Q6KZH9, THIE_PICTO ;
DR   A2CB21, THIE_PROM3 ;  Q7VAV5, THIE_PROMA ;  B4EYU2, THIE_PROMH ;
DR   Q7V8I3, THIE_PROMM ;  Q7V0I3, THIE_PROMP ;  A2BSJ5, THIE_PROMS ;
DR   Q48DP2, THIE_PSE14 ;  A6V0D3, THIE_PSEA7 ;  B7V9E0, THIE_PSEA8 ;
DR   Q02SE4, THIE_PSEAB ;  Q9HX40, THIE_PSEAE ;  Q1I4H6, THIE_PSEE4 ;
DR   Q4K5I7, THIE_PSEF5 ;  C3K2K2, THIE_PSEFS ;  A4XYV5, THIE_PSEMY ;
DR   A5W9G9, THIE_PSEP1 ;  Q3K6C1, THIE_PSEPF ;  B0KJV8, THIE_PSEPG ;
DR   Q88DP1, THIE_PSEPK ;  B1J1Y7, THIE_PSEPW ;  Q87VY6, THIE_PSESM ;
DR   Q4ZNA1, THIE_PSEU2 ;  A4VQX9, THIE_PSEU5 ;  A5WDP0, THIE_PSYWF ;
DR   Q9UZQ5, THIE_PYRAB ;  Q8U192, THIE_PYRFU ;  O58878, THIE_PYRHO ;
DR   O34294, THIE_RHIEC ;  Q7UQH1, THIE_RHOBA ;  B6INN5, THIE_RHOCS ;
DR   Q21VL5, THIE_RHOFT ;  A7NRF7, THIE_ROSCS ;  A5UUL3, THIE_ROSS1 ;
DR   B8I3J4, THIE_RUMCH ;  Q21MI9, THIE_SACD2 ;  A4F727, THIE_SACEN ;
DR   B5F1H6, THIE_SALA4 ;  A8M4E6, THIE_SALAI ;  A9MHD7, THIE_SALAR ;
DR   Q57H62, THIE_SALCH ;  B5FQK8, THIE_SALDC ;  B5QYE8, THIE_SALEP ;
DR   B5RFJ1, THIE_SALG2 ;  B4TCT2, THIE_SALHS ;  B4T0Z5, THIE_SALNS ;
DR   Q5PKA7, THIE_SALPA ;  A9N0K5, THIE_SALPB ;  B5BJR2, THIE_SALPK ;
DR   Q2S2A8, THIE_SALRD ;  B4TQK3, THIE_SALSV ;  Q8Z325, THIE_SALTI ;
DR   A4XBL2, THIE_SALTO ;  Q9L9I8, THIE_SALTY ;  A8G8F3, THIE_SERP5 ;
DR   B2TWI0, THIE_SHIB3 ;  Q31U04, THIE_SHIBS ;  Q32AG6, THIE_SHIDS ;
DR   Q0SY07, THIE_SHIF8 ;  Q83PB9, THIE_SHIFL ;  Q3YUZ1, THIE_SHISS ;
DR   A7X4S8, THIE_STAA1 ;  A6U3H7, THIE_STAA2 ;  Q2FF35, THIE_STAA3 ;
DR   Q2FWG3, THIE_STAA8 ;  A5IUN7, THIE_STAA9 ;  Q2YUL2, THIE_STAAB ;
DR   Q5HEA8, THIE_STAAC ;  A6QIT5, THIE_STAAE ;  P66918, THIE_STAAM ;
DR   P66919, THIE_STAAN ;  Q6GEY4, THIE_STAAR ;  Q6G7L9, THIE_STAAS ;
DR   Q8NVH5, THIE_STAAW ;  Q9RGS5, THIE_STACT ;  Q5HMD0, THIE_STAEQ ;
DR   Q8CNK2, THIE_STAES ;  Q4L7X3, THIE_STAHJ ;  Q49Z39, THIE_STAS1 ;
DR   Q3K1L6, THIE_STRA1 ;  Q8E5W9, THIE_STRA3 ;  Q8E092, THIE_STRA5 ;
DR   Q82AF9, THIE_STRAW ;  Q9S2V2, THIE_STRCO ;  A4W0K4, THIE_STRS2 ;
DR   A5GMH7, THIE_SYNPW ;  Q7U5U1, THIE_SYNPX ;  Q0IC17, THIE_SYNS3 ;
DR   Q3AL68, THIE_SYNSC ;  Q0AZ86, THIE_SYNWW ;  P72965, THIE_SYNY3 ;
DR   Q9HIQ4, THIE_THEAC ;  Q8DHK2, THIE_THEEB ;  Q47R33, THIE_THEFY ;
DR   Q72KL8, THIE_THET2 ;  Q5SKG9, THIE_THET8 ;  Q97BE8, THIE_THEVO ;
DR   Q3SFU7, THIE_THIDA ;  B8GLE3, THIE_THISH ;  A7N7S3, THIE_VIBCB ;
DR   Q87JW8, THIE_VIBPA ;  Q7M9N9, THIE_WOLSU ;  Q8PH45, THIE_XANAC ;
DR   Q4UYA4, THIE_XANC8 ;  Q8P5R7, THIE_XANCP ;  A7IGG9, THIE_XANP2 ;
DR   Q9PGC4, THIE_XYLFA ;  Q87AX6, THIE_XYLFT ;  A7FNH7, THIE_YERP3 ;
DR   Q1C1U8, THIE_YERPA ;  Q8ZAQ1, THIE_YERPE ;  Q1CN71, THIE_YERPN ;
DR   A4TS25, THIE_YERPP ;  Q66FP6, THIE_YERPS ;  Q67T51, THIME_SYMTH;
DR   O26949, THIN_METTH ;  Q5M731, TPS1L_ARATH;  O48881, TPS1_BRANA ;
DR   Q2QWK9, TPS1_ORYSJ ;
//