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ENZYME entry: EC 2.5.1.30

Accepted Name
Heptaprenyl diphosphate synthase.
Alternative Name(s)
All-trans-heptaprenyl-diphosphate synthase.
HepPP synthase.
Heptaprenyl pyrophosphate synthetase.
Trans-hexaprenyltranstransferase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> 4 diphosphate + all-trans-heptaprenyl diphosphate
Comment(s)
  • This enzyme catalyzes the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7.
  • The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
Cross-references
BRENDA2.5.1.30
EC2PDB2.5.1.30
ExplorEnz2.5.1.30
PRIAM enzyme-specific profiles2.5.1.30
KEGG Ligand Database for Enzyme Nomenclature2.5.1.30
IUBMB Enzyme Nomenclature2.5.1.30
IntEnz2.5.1.30
MEDLINEFind literature relating to 2.5.1.30
MetaCyc2.5.1.30
Rhea expert-curated reactions2.5.1.30
UniProtKB/Swiss-Prot
P31112, HEPS1_BACSU;  P55784, HEPS1_GEOSE;  P31114, HEPS2_BACSU;  
P55785, HEPS2_GEOSE;  

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