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ENZYME entry: EC 2.5.1.39

Accepted Name
4-hydroxybenzoate polyprenyltransferase.
Alternative Name(s)
4-hydroxybenzoate nonaprenyltransferase.
Reaction catalysed
A polyprenyl diphosphate + 4-hydroxybenzoate <=> diphosphate + a 4-hydroxy-3-polyprenylbenzoate
Comment(s)
  • This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound.
  • The number of isoprenoid subunits in the side chain varies in different species.
  • The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Cross-references
PROSITEPDOC00727
BRENDA2.5.1.39
EC2PDB2.5.1.39
ExplorEnz2.5.1.39
PRIAM enzyme-specific profiles2.5.1.39
KEGG Ligand Database for Enzyme Nomenclature2.5.1.39
IUBMB Enzyme Nomenclature2.5.1.39
IntEnz2.5.1.39
MEDLINEFind literature relating to 2.5.1.39
MetaCyc2.5.1.39
UniProtKB/Swiss-Prot
Q16QL3, COQ2_AEDAE;  Q93YP7, COQ2_ARATH;  Q2KIQ4, COQ2_BOVIN;  
Q8I7J4, COQ2_CAEEL;  Q54U71, COQ2_DICDI;  Q9VHS7, COQ2_DROME;  
Q298G6, COQ2_DROPS;  Q96H96, COQ2_HUMAN;  Q66JT7, COQ2_MOUSE;  
Q499N4, COQ2_RAT;  Q10252, COQ2_SCHPO;  P32378, COQ2_YEAST;  
Q55500, PLQA_SYNY3;  A1TJR2, UBIA_ACIAC;  Q6F9N8, UBIA_ACIAD;  
B9MBT5, UBIA_ACIET;  A1W307, UBIA_ACISJ;  A3N0I2, UBIA_ACTP2;  
B3H1F9, UBIA_ACTP7;  B0BPA2, UBIA_ACTPJ;  A0KEP9, UBIA_AERHH;  
A4STB5, UBIA_AERS4;  Q0VTA7, UBIA_ALCBS;  Q5E207, UBIA_ALIF1;  
B5FCB4, UBIA_ALIFM;  B6ENU2, UBIA_ALISL;  Q0A5V9, UBIA_ALKEH;  
Q5P5M0, UBIA_AROAE;  A1K2P1, UBIA_AZOSB;  C1DK47, UBIA_AZOVD;  
Q7VQU0, UBIA_BLOFL;  Q494A7, UBIA_BLOPB;  B1YTH7, UBIA_BURA4;  
Q1BYZ6, UBIA_BURCA;  B1JVZ5, UBIA_BURCC;  A0K4Q5, UBIA_BURCH;  
Q0BI45, UBIA_BURCM;  Q39JF0, UBIA_BURL3;  A9AGE2, UBIA_BURM1;  
A3MPC2, UBIA_BURM7;  Q62H69, UBIA_BURMA;  A3NZ16, UBIA_BURP0;  
Q3JNX1, UBIA_BURP1;  A3NDA6, UBIA_BURP6;  Q63R13, UBIA_BURPS;  
Q2SZ16, UBIA_BURTA;  A4JBP9, UBIA_BURVG;  Q1QSG2, UBIA_CHRSD;  
A8AN88, UBIA_CITK8;  Q48AL9, UBIA_COLP3;  B6J612, UBIA_COXB1;  
B6J375, UBIA_COXB2;  A9KGW7, UBIA_COXBN;  A9N9X0, UBIA_COXBR;  
Q83F93, UBIA_COXBU;  A7MPP0, UBIA_CROS8;  Q1LJ64, UBIA_CUPMC;  
Q0K739, UBIA_CUPNH;  Q46XG9, UBIA_CUPNJ;  Q47J11, UBIA_DECAR;  
A7ZUR2, UBIA_ECO24;  B7UPK1, UBIA_ECO27;  B7MJ30, UBIA_ECO45;  
B7LAY8, UBIA_ECO55;  P0AGK3, UBIA_ECO57;  B5Z181, UBIA_ECO5E;  
B7NS04, UBIA_ECO7I;  B7MRH2, UBIA_ECO81;  B7M7V3, UBIA_ECO8A;  
C5A133, UBIA_ECOBW;  B1XC39, UBIA_ECODH;  A8A7E0, UBIA_ECOHS;  
A1AIL7, UBIA_ECOK1;  Q0TA22, UBIA_ECOL5;  P0AGK2, UBIA_ECOL6;  
B1IUL2, UBIA_ECOLC;  P0AGK1, UBIA_ECOLI;  B7NFY4, UBIA_ECOLU;  
B6I5Q5, UBIA_ECOSE;  B1LPK5, UBIA_ECOSM;  Q1R3P6, UBIA_ECOUT;  
C5B704, UBIA_EDWI9;  A4W5F3, UBIA_ENT38;  B7LL12, UBIA_ESCF3;  
B0U042, UBIA_FRAP2;  Q14HY6, UBIA_FRAT1;  A7NA50, UBIA_FRATF;  
Q2A564, UBIA_FRATH;  B2SF41, UBIA_FRATM;  A0Q4X3, UBIA_FRATN;  
Q0BNI0, UBIA_FRATO;  Q5NGI4, UBIA_FRATT;  A4IYU3, UBIA_FRATW;  
Q7VL38, UBIA_HAEDU;  Q0I0W3, UBIA_HAES1;  Q2SNV5, UBIA_HAHCH;  
A1WVM9, UBIA_HALHL;  A4G1Y9, UBIA_HERAR;  B0UUY3, UBIA_HISS2;  
Q31DM4, UBIA_HYDCU;  Q5QUP3, UBIA_IDILO;  A6SUU0, UBIA_JANMA;  
B5XXZ2, UBIA_KLEP3;  A6TGU9, UBIA_KLEP7;  Q5X5D5, UBIA_LEGPA;  
A5IBS2, UBIA_LEGPC;  Q5ZVL0, UBIA_LEGPH;  Q5WWR8, UBIA_LEGPL;  
A1U6P5, UBIA_MARHV;  A6W3L5, UBIA_MARMS;  Q608Z9, UBIA_METCA;  
Q1GXB3, UBIA_METFK;  A2SMA7, UBIA_METPP;  Q5F9S8, UBIA_NEIG1;  
B4RK00, UBIA_NEIG2;  A9M390, UBIA_NEIM0;  Q9JV93, UBIA_NEIMA;  
Q9K083, UBIA_NEIMB;  A1KSZ7, UBIA_NEIMF;  Q0AGZ9, UBIA_NITEC;  
Q82TP2, UBIA_NITEU;  Q2Y5S3, UBIA_NITMU;  Q3JBS8, UBIA_NITOC;  
B2JGG3, UBIA_PARP8;  B2SXA0, UBIA_PARPJ;  Q145H3, UBIA_PARXL;  
P57970, UBIA_PASMU;  Q6D9I8, UBIA_PECAS;  C6DKC9, UBIA_PECCP;  
Q7MZB6, UBIA_PHOLL;  Q6LVS3, UBIA_PHOPR;  A4SZT5, UBIA_POLAQ;  
A1VJ21, UBIA_POLNA;  B1XRV6, UBIA_POLNS;  Q12GA4, UBIA_POLSJ;  
O52366, UBIA_PROST;  Q48BQ5, UBIA_PSE14;  Q15ZT9, UBIA_PSEA6;  
A6VEG6, UBIA_PSEA7;  B7V5P9, UBIA_PSEA8;  Q02E04, UBIA_PSEAB;  
Q9HTK0, UBIA_PSEAE;  Q1I2R3, UBIA_PSEE4;  Q4K3L9, UBIA_PSEF5;  
C3K4C4, UBIA_PSEFS;  Q3IHW5, UBIA_PSEHT;  A4Y0P0, UBIA_PSEMY;  
A5WB34, UBIA_PSEP1;  Q3K4G3, UBIA_PSEPF;  B0KQB7, UBIA_PSEPG;  
Q88C65, UBIA_PSEPK;  B1J454, UBIA_PSEPW;  Q87U39, UBIA_PSESM;  
Q4ZLB4, UBIA_PSEU2;  A4VGN3, UBIA_PSEU5;  Q4FR08, UBIA_PSYA2;  
Q1Q996, UBIA_PSYCK;  A1T087, UBIA_PSYIN;  Q8XVY9, UBIA_RALSO;  
Q21S73, UBIA_RHOFT;  Q21DY7, UBIA_SACD2;  B5F1Q3, UBIA_SALA4;  
A9MH90, UBIA_SALAR;  Q57GZ3, UBIA_SALCH;  B5FQQ8, UBIA_SALDC;  
B5QZ59, UBIA_SALEP;  B5R7T3, UBIA_SALG2;  B4TDL7, UBIA_SALHS;  
B4T1S9, UBIA_SALNS;  Q5PL17, UBIA_SALPA;  A9N1L3, UBIA_SALPB;  
C0Q4D9, UBIA_SALPC;  B5BJV7, UBIA_SALPK;  B4TQQ2, UBIA_SALSV;  
Q8XGZ7, UBIA_SALTI;  Q7CPB4, UBIA_SALTY;  A8GKB7, UBIA_SERP5;  
A1S2M4, UBIA_SHEAM;  B8E613, UBIA_SHEB2;  A3CZR1, UBIA_SHEB5;  
A6WT76, UBIA_SHEB8;  A9L4Q8, UBIA_SHEB9;  Q12S01, UBIA_SHEDO;  
Q07XN2, UBIA_SHEFN;  B0TRE7, UBIA_SHEHH;  A3QIF2, UBIA_SHELP;  
Q8EJJ5, UBIA_SHEON;  A8GZR0, UBIA_SHEPA;  A4YAV1, UBIA_SHEPC;  
B8CTT5, UBIA_SHEPW;  A0KSE2, UBIA_SHESA;  A8FQF8, UBIA_SHESH;  
Q0HN13, UBIA_SHESM;  Q0HQR8, UBIA_SHESR;  A1RFH5, UBIA_SHESW;  
B1KKU2, UBIA_SHEWM;  B2TX76, UBIA_SHIB3;  Q31TU8, UBIA_SHIBS;  
Q327U7, UBIA_SHIDS;  Q0SXQ7, UBIA_SHIF8;  Q83IP7, UBIA_SHIFL;  
Q3YUU4, UBIA_SHISS;  Q2NR07, UBIA_SODGM;  Q3SLJ4, UBIA_THIDA;  
C4L7X6, UBIA_TOLAT;  A1WKC0, UBIA_VEREI;  A5CXV6, UBIA_VESOH;  
A5F4H4, UBIA_VIBC3;  A7N0X0, UBIA_VIBCB;  Q9KVP7, UBIA_VIBCH;  
C3LPT6, UBIA_VIBCM;  Q87KM9, UBIA_VIBPA;  B7VMA0, UBIA_VIBTL;  
Q8DD49, UBIA_VIBVU;  Q7MQ87, UBIA_VIBVY;  Q8PQD5, UBIA_XANAC;  
Q3BYM7, UBIA_XANC5;  Q4UZN6, UBIA_XANC8;  B0RMR4, UBIA_XANCB;  
Q8PDE8, UBIA_XANCP;  Q2P8F5, UBIA_XANOM;  B2SS70, UBIA_XANOP;  
Q5H5R3, UBIA_XANOR;  B2I675, UBIA_XYLF2;  Q9PH76, UBIA_XYLFA;  
B0U2A2, UBIA_XYLFM;  Q87F82, UBIA_XYLFT;  A1JRU3, UBIA_YERE8;  
A7FN99, UBIA_YERP3;  Q1C0T8, UBIA_YERPA;  B2K1U4, UBIA_YERPB;  
Q7CKP5, UBIA_YERPE;  A9QYL1, UBIA_YERPG;  Q1CE95, UBIA_YERPN;  
A4TRU8, UBIA_YERPP;  Q66FH0, UBIA_YERPS;  B1JNE6, UBIA_YERPY;  

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