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ENZYME

ENZYME entry: EC 2.5.1.39

Accepted Name
4-hydroxybenzoate polyprenyltransferase
Alternative Name(s)
4-hydroxybenzoate nonaprenyltransferase
Reaction catalysed
4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
Comment(s)
  • This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound.
  • The number of isoprenoid subunits in the side chain varies in different species.
  • The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Cross-references
BRENDA2.5.1.39
EC2PDB2.5.1.39
ExplorEnz2.5.1.39
PRIAM enzyme-specific profiles2.5.1.39
KEGG Ligand Database for Enzyme Nomenclature2.5.1.39
IUBMB Enzyme Nomenclature2.5.1.39
IntEnz2.5.1.39
MEDLINEFind literature relating to 2.5.1.39
MetaCyc2.5.1.39
Rhea expert-curated reactions2.5.1.39
UniProtKB/Swiss-Prot
Q16QL3, COQ2_AEDAEQ93YP7, COQ2_ARATHQ2KIQ4, COQ2_BOVIN
Q8I7J4, COQ2_CAEELQ54U71, COQ2_DICDIQ9VHS7, COQ2_DROME
Q298G6, COQ2_DROPSQ96H96, COQ2_HUMANQ66JT7, COQ2_MOUSE
Q499N4, COQ2_RATQ10252, COQ2_SCHPOP32378, COQ2_YEAST
Q55500, PLQA_SYNY3D2HKB0, UBIA1_AILMEQ5ZKS8, UBIA1_CHICK
E7FB98, UBIA1_DANREQ9Y5Z9, UBIA1_HUMANQ9DC60, UBIA1_MOUSE
D3ZG27, UBIA1_RATQ28HR4, UBIA1_XENTRA1TJR2, UBIA_ACIAC
Q6F9N8, UBIA_ACIADB9MBT5, UBIA_ACIETA1W307, UBIA_ACISJ
A3N0I2, UBIA_ACTP2B3H1F9, UBIA_ACTP7B0BPA2, UBIA_ACTPJ
A0KEP9, UBIA_AERHHA4STB5, UBIA_AERS4Q21S73, UBIA_ALBFT
Q0VTA7, UBIA_ALCBSQ5E207, UBIA_ALIF1B5FCB4, UBIA_ALIFM
B6ENU2, UBIA_ALISLQ0A5V9, UBIA_ALKEHQ5P5M0, UBIA_AROAE
A1K2P1, UBIA_AZOSBC1DK47, UBIA_AZOVDQ7VQU0, UBIA_BLOFL
Q494A7, UBIA_BLOPBB1YTH7, UBIA_BURA4A0K4Q5, UBIA_BURCH
Q0BI45, UBIA_BURCMQ39JF0, UBIA_BURL3A9AGE2, UBIA_BURM1
A3MPC2, UBIA_BURM7Q62H69, UBIA_BURMAB1JVZ5, UBIA_BURO0
Q1BYZ6, UBIA_BURO1A3NZ16, UBIA_BURP0Q3JNX1, UBIA_BURP1
A3NDA6, UBIA_BURP6Q63R13, UBIA_BURPSQ2SZ16, UBIA_BURTA
A4JBP9, UBIA_BURVGQ1QSG2, UBIA_CHRSDA8AN88, UBIA_CITK8
Q48AL9, UBIA_COLP3B6J612, UBIA_COXB1B6J375, UBIA_COXB2
A9KGW7, UBIA_COXBNA9N9X0, UBIA_COXBRQ83F93, UBIA_COXBU
A7MPP0, UBIA_CROS8Q1LJ64, UBIA_CUPMCQ0K739, UBIA_CUPNH
Q46XG9, UBIA_CUPPJQ47J11, UBIA_DECARA7ZUR2, UBIA_ECO24
B7UPK1, UBIA_ECO27B7MJ30, UBIA_ECO45B7LAY8, UBIA_ECO55
P0AGK3, UBIA_ECO57B5Z181, UBIA_ECO5EB7NS04, UBIA_ECO7I
B7MRH2, UBIA_ECO81B7M7V3, UBIA_ECO8AC5A133, UBIA_ECOBW
B1XC39, UBIA_ECODHA8A7E0, UBIA_ECOHSA1AIL7, UBIA_ECOK1
Q0TA22, UBIA_ECOL5P0AGK2, UBIA_ECOL6B1IUL2, UBIA_ECOLC
P0AGK1, UBIA_ECOLIB7NFY4, UBIA_ECOLUB6I5Q5, UBIA_ECOSE
B1LPK5, UBIA_ECOSMQ1R3P6, UBIA_ECOUTC5B704, UBIA_EDWI9
A4W5F3, UBIA_ENT38B7LL12, UBIA_ESCF3B0U042, UBIA_FRAP2
Q14HY6, UBIA_FRAT1A7NA50, UBIA_FRATFQ2A564, UBIA_FRATH
B2SF41, UBIA_FRATMA0Q4X3, UBIA_FRATNQ0BNI0, UBIA_FRATO
Q5NGI4, UBIA_FRATTA4IYU3, UBIA_FRATWQ7VL38, UBIA_HAEDU
Q0I0W3, UBIA_HAES1Q2SNV5, UBIA_HAHCHA1WVM9, UBIA_HALHL
A4G1Y9, UBIA_HERARB0UUY3, UBIA_HISS2Q31DM4, UBIA_HYDCU
Q5QUP3, UBIA_IDILOA6SUU0, UBIA_JANMAB5XXZ2, UBIA_KLEP3
A6TGU9, UBIA_KLEP7Q5X5D5, UBIA_LEGPAA5IBS2, UBIA_LEGPC
Q5ZVL0, UBIA_LEGPHQ5WWR8, UBIA_LEGPLA6W3L5, UBIA_MARMS
A1U6P5, UBIA_MARN8Q608Z9, UBIA_METCAQ1GXB3, UBIA_METFK
A2SMA7, UBIA_METPPQ5F9S8, UBIA_NEIG1B4RK00, UBIA_NEIG2
A9M390, UBIA_NEIM0Q9JV93, UBIA_NEIMAQ9K083, UBIA_NEIMB
A1KSZ7, UBIA_NEIMFQ0AGZ9, UBIA_NITECQ82TP2, UBIA_NITEU
Q2Y5S3, UBIA_NITMUQ3JBS8, UBIA_NITOCB2JGG3, UBIA_PARP8
B2SXA0, UBIA_PARPJQ145H3, UBIA_PARXLP57970, UBIA_PASMU
Q6D9I8, UBIA_PECASC6DKC9, UBIA_PECCPQ7MZB6, UBIA_PHOLL
Q6LVS3, UBIA_PHOPRA4SZT5, UBIA_POLAQA1VJ21, UBIA_POLNA
B1XRV6, UBIA_POLNSQ12GA4, UBIA_POLSJO52366, UBIA_PROST
Q48BQ5, UBIA_PSE14Q15ZT9, UBIA_PSEA6A6VEG6, UBIA_PSEA7
B7V5P9, UBIA_PSEA8Q02E04, UBIA_PSEABQ9HTK0, UBIA_PSEAE
Q1I2R3, UBIA_PSEE4Q4K3L9, UBIA_PSEF5C3K4C4, UBIA_PSEFS
A4Y0P0, UBIA_PSEMYA5WB34, UBIA_PSEP1Q3K4G3, UBIA_PSEPF
B0KQB7, UBIA_PSEPGQ88C65, UBIA_PSEPKB1J454, UBIA_PSEPW
Q87U39, UBIA_PSESMQ3IHW5, UBIA_PSET1Q4ZLB4, UBIA_PSEU2
Q4FR08, UBIA_PSYA2Q1Q996, UBIA_PSYCKA1T087, UBIA_PSYIN
Q8XVY9, UBIA_RALSOQ21DY7, UBIA_SACD2B5F1Q3, UBIA_SALA4
A9MH90, UBIA_SALARQ57GZ3, UBIA_SALCHB5FQQ8, UBIA_SALDC
B5QZ59, UBIA_SALEPB5R7T3, UBIA_SALG2B4TDL7, UBIA_SALHS
B4T1S9, UBIA_SALNSQ5PL17, UBIA_SALPAA9N1L3, UBIA_SALPB
C0Q4D9, UBIA_SALPCB5BJV7, UBIA_SALPKB4TQQ2, UBIA_SALSV
Q8XGZ7, UBIA_SALTIQ7CPB4, UBIA_SALTYA8GKB7, UBIA_SERP5
A1S2M4, UBIA_SHEAMB8E613, UBIA_SHEB2A3CZR1, UBIA_SHEB5
A6WT76, UBIA_SHEB8A9L4Q8, UBIA_SHEB9Q12S01, UBIA_SHEDO
Q07XN2, UBIA_SHEFNB0TRE7, UBIA_SHEHHA3QIF2, UBIA_SHELP
Q8EJJ5, UBIA_SHEONA8GZR0, UBIA_SHEPAA4YAV1, UBIA_SHEPC
B8CTT5, UBIA_SHEPWA0KSE2, UBIA_SHESAA8FQF8, UBIA_SHESH
Q0HN13, UBIA_SHESMQ0HQR8, UBIA_SHESRA1RFH5, UBIA_SHESW
B1KKU2, UBIA_SHEWMB2TX76, UBIA_SHIB3Q31TU8, UBIA_SHIBS
Q327U7, UBIA_SHIDSQ0SXQ7, UBIA_SHIF8Q83IP7, UBIA_SHIFL
Q3YUU4, UBIA_SHISSQ2NR07, UBIA_SODGMA4VGN3, UBIA_STUS1
Q3SLJ4, UBIA_THIDAC4L7X6, UBIA_TOLATA1WKC0, UBIA_VEREI
A5CXV6, UBIA_VESOHB7VMA0, UBIA_VIBA3A7N0X0, UBIA_VIBC1
A5F4H4, UBIA_VIBC3Q9KVP7, UBIA_VIBCHC3LPT6, UBIA_VIBCM
Q87KM9, UBIA_VIBPAQ8DD49, UBIA_VIBVUQ7MQ87, UBIA_VIBVY
Q8PQD5, UBIA_XANACQ3BYM7, UBIA_XANC5Q4UZN6, UBIA_XANC8
B0RMR4, UBIA_XANCBQ8PDE8, UBIA_XANCPQ2P8F5, UBIA_XANOM
B2SS70, UBIA_XANOPQ5H5R3, UBIA_XANORB2I675, UBIA_XYLF2
Q9PH76, UBIA_XYLFAB0U2A2, UBIA_XYLFMQ87F82, UBIA_XYLFT
A1JRU3, UBIA_YERE8A7FN99, UBIA_YERP3Q1C0T8, UBIA_YERPA
B2K1U4, UBIA_YERPBQ7CKP5, UBIA_YERPEA9QYL1, UBIA_YERPG
Q1CE95, UBIA_YERPNA4TRU8, UBIA_YERPPQ66FH0, UBIA_YERPS
B1JNE6, UBIA_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-