ID   2.5.1.46
DE   deoxyhypusine synthase.
AN   (4-aminobutyl)lysine synthase.
AN   [eIF-5A]-deoxyhypusine synthase.
AN   spermidine dehydrogenase.
CA   [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine +
CA   propane-1,3-diamine.
CC   -!- The eukaryotic initiation factor eIF5A contains a hypusine residue
CC       that is essential for activity.
CC   -!- Catalyzes the first reaction of hypusine formation from one specific
CC       lysine residue of the eIF5A precursor.
CC   -!- The reaction occurs in four steps: NAD(+)-dependent dehydrogenation
CC       of spermidine (1a), formation of an enzyme-imine intermediate by
CC       transfer of the 4-aminobutylidene group from dehydrospermidine to the
CC       active site lysine residue (1b), transfer of the same
CC       4-aminobutylidene group from the enzyme intermediate to the e1F5A
CC       precursor (1c), reduction of the e1F5A-imine intermediate to form a
CC       deoxyhypusine residue (1d).
CC   -!- Hence the overall reaction is transfer of a 4-aminobutyl group.
CC   -!- For the plant enzyme, homospermidine can substitute for spermidine
CC       and putrescine can substitute for the lysine residue of the eIF5A
CC       precursor.
CC   -!- Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29.
CC   -!- Formerly EC 1.1.1.249.
DR   O28088, DHYS1_ARCFU;  Q8TS38, DHYS1_METAC;  Q8PV89, DHYS1_METMA;
DR   O27984, DHYS2_ARCFU;  Q8TLM3, DHYS2_METAC;  Q8Q051, DHYS2_METMA;
DR   Q38BX0, DHYSC_TRYB2;  Q9YE72, DHYS_AERPE ;  Q9FI94, DHYS_ARATH ;
DR   Q6EWQ6, DHYS_BOVIN ;  Q6RJS2, DHYS_BRANA ;  Q9XXJ0, DHYS_CAEEL ;
DR   Q6FRN2, DHYS_CANGA ;  Q6BJH5, DHYS_DEBHA ;  Q9AXQ8, DHYS_DIACA ;
DR   Q54MQ7, DHYS_DICDI ;  Q9VSF4, DHYS_DROME ;  Q8SQN2, DHYS_ENCCU ;
DR   Q75EW4, DHYS_EREGS ;  B0R5L2, DHYS_HALS3 ;  Q9HPX2, DHYS_HALSA ;
DR   P49366, DHYS_HUMAN ;  A8AA61, DHYS_IGNH4 ;  Q6CNG7, DHYS_KLULA ;
DR   B5APK2, DHYS_LEIDO ;  Q58224, DHYS_METJA ;  Q8TXD7, DHYS_METKA ;
DR   A4YHK6, DHYS_METS5 ;  Q977X6, DHYS_METTE ;  O26230, DHYS_METTH ;
DR   A6URC0, DHYS_METVS ;  Q3TXU5, DHYS_MOUSE ;  Q9AXQ9, DHYS_MUSAC ;
DR   P49365, DHYS_NEUCR ;  Q6KZL5, DHYS_PICTO ;  Q9V0N5, DHYS_PYRAB ;
DR   Q8ZT09, DHYS_PYRAE ;  A3MVC9, DHYS_PYRCJ ;  Q8U407, DHYS_PYRFU ;
DR   O50105, DHYS_PYRHO ;  Q6AY53, DHYS_RAT   ;  Q97ZF1, DHYS_SACS2 ;
DR   O94337, DHYS_SCHPO ;  Q9SC14, DHYS_SENVE ;  Q9AXR0, DHYS_SOLLC ;
DR   Q4J978, DHYS_SULAC ;  C3N5B4, DHYS_SULIA ;  C4KGY0, DHYS_SULIK ;
DR   C3MPN8, DHYS_SULIL ;  C3MYN2, DHYS_SULIM ;  C3NHT5, DHYS_SULIN ;
DR   C3NDW8, DHYS_SULIY ;  Q971T3, DHYS_SULTO ;  Q9HL74, DHYS_THEAC ;
DR   C5A5L0, DHYS_THEGJ ;  Q5JEY0, DHYS_THEKO ;  B6YVB1, DHYS_THEON ;
DR   Q97BN6, DHYS_THEVO ;  Q9SC80, DHYS_TOBAC ;  Q6CG56, DHYS_YARLI ;
DR   P38791, DHYS_YEAST ;
//