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ENZYME entry: EC 2.5.1.47

Accepted Name
Cysteine synthase.
Alternative Name(s)
Acetylserine sulfhydrylase.
Cysteine synthetase.
O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide).
O-acetyl-L-serine sulfhydrylase.
O-acetyl-L-serine sulfohydrolase.
O-acetylserine (thiol)-lyase.
O-acetylserine (thiol)-lyase A.
O-acetylserine sulfhydrylase.
OAS sulfhydrylase.
Reaction catalysed
O-acetyl-L-serine + hydrogen sulfide <=> L-cysteine + acetate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors.
  • Not identical with EC 2.5.1.51, EC 2.5.1.52 and EC 2.5.1.53.
  • Formerly EC 4.2.99.8.
Cross-references
PROSITEPDOC00700
BRENDA2.5.1.47
EC2PDB2.5.1.47
ExplorEnz2.5.1.47
PRIAM enzyme-specific profiles2.5.1.47
KEGG Ligand Database for Enzyme Nomenclature2.5.1.47
IUBMB Enzyme Nomenclature2.5.1.47
IntEnz2.5.1.47
MEDLINEFind literature relating to 2.5.1.47
MetaCyc2.5.1.47
Rhea expert-curated reactions2.5.1.47
UniProtKB/Swiss-Prot
Q76MX2, CAS1_SOLTU;  Q9FS29, CAS2_SOLTU;  F4K5T2, CGL_ARATH;  
Q9S757, CYSC1_ARATH;  Q43153, CYSC_SPIOL;  Q9S6Z7, CYSD1_ARATH;  
Q9SXS7, CYSD2_ARATH;  Q92441, CYSD_KLULA;  P06106, CYSD_YEAST;  
P47998, CYSK1_ARATH;  O23733, CYSK1_BRAJU;  Q93244, CYSK1_CAEEL;  
Q9XEA6, CYSK1_ORYSJ;  O23735, CYSK2_BRAJU;  O45679, CYSK2_CAEEL;  
Q9XEA8, CYSK2_ORYSJ;  O01592, CYSK3_CAEEL;  Q5BD67, CYSKL_EMENI;  
Q7SHQ1, CYSKL_NEUCR;  P87131, CYSKL_SCHPO;  Q43725, CYSKM_ARATH;  
P47999, CYSKP_ARATH;  P31300, CYSKP_CAPAN;  O81155, CYSKP_SOLTU;  
P32260, CYSKP_SPIOL;  P37887, CYSK_BACSU;  P57171, CYSK_BUCAI;  
Q8KA48, CYSK_BUCAP;  Q43317, CYSK_CITLA;  P81340, CYSK_CLOPA;  
Q54CN7, CYSK_DICDI;  P0ABK6, CYSK_ECO57;  P0ABK5, CYSK_ECOLI;  
P50867, CYSK_EMENI;  Q59447, CYSK_FLAS3;  P45040, CYSK_HAEIN;  
P80608, CYSK_MAIZE;  P0A535, CYSK_MYCBO;  O32978, CYSK_MYCLE;  
P9WP54, CYSK_MYCTO;  P9WP55, CYSK_MYCTU;  Q7DDL5, CYSK_NEIMB;  
Q7RYW6, CYSK_NEUCR;  P84538, CYSK_POPEU;  P0A1E4, CYSK_SALTI;  
P0A1E3, CYSK_SALTY;  O59701, CYSK_SCHPO;  O81154, CYSK_SOLTU;  
Q00834, CYSK_SPIOL;  Q5HIG2, CYSK_STAAC;  P63870, CYSK_STAAM;  
P63871, CYSK_STAAN;  Q6GJF8, CYSK_STAAR;  Q6GBX5, CYSK_STAAS;  
P63872, CYSK_STAAW;  Q5HRP1, CYSK_STAEQ;  Q8CMT6, CYSK_STAES;  
Q59918, CYSK_STAHA;  Q5XAQ3, CYSK_STRP6;  Q59966, CYSK_SYNE7;  
P73410, CYSK_SYNY3;  P38076, CYSK_WHEAT;  O67507, CYSM_AQUAE;  
O34476, CYSM_BACSU;  P71128, CYSM_CAMJE;  P16703, CYSM_ECOLI;  
Q9ZMW6, CYSM_HELPJ;  P56067, CYSM_HELPY;  Q9I526, CYSM_PSEAE;  
P48028, CYSM_PSESY;  P29848, CYSM_SALTY;  Q9YBL2, CYSO_AERPE;  
D2Z027, DCSD_STRLA;  P53206, MCY1_YEAST;  P55708, Y4XP_SINFN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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