ID 2.5.1.58 DE protein farnesyltransferase. AN CAAX farnesyltransferase. AN FTase. CA (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + CA S-(2E,6E)-farnesyl-L-cysteinyl-[protein]. CC -!- This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the CC protein prenyltransferase family of enzymes. CC -!- Catalyzes the formation of a thioether linkage between the C-1 of an CC isoprenyl group and a cysteine residue fourth from the C-terminus of CC the protein. CC -!- These protein acceptors have the C-terminal sequence CA(1)A(2)X, CC where the terminal residue, X, is preferably serine, methionine, CC alanine or glutamine; leucine makes the protein a substrate for CC EC 2.5.1.59. CC -!- The enzymes are relaxed in specificity for A(1), but cannot act if CC A(2) is aromatic. CC -!- Substrates of the prenyltransferases include Ras, Rho, Rab, other CC Ras-related small GTP-binding proteins, gamma-subunits of CC heterotrimeric G-proteins, nuclear lamins, centromeric proteins and CC many proteins involved in visual signal transduction. DR Q9LX33, FNTA_ARATH ; P29702, FNTA_BOVIN ; Q9Y765, FNTA_CANAX ; DR Q54RT9, FNTA_DICDI ; P49354, FNTA_HUMAN ; Q61239, FNTA_MOUSE ; DR O24304, FNTA_PEA ; Q04631, FNTA_RAT ; O60052, FNTA_SCHPO ; DR P93227, FNTA_SOLLC ; P29703, FNTA_YEAST ; Q38920, FNTB_ARATH ; DR P49355, FNTB_BOVIN ; Q55D51, FNTB_DICDI ; P49356, FNTB_HUMAN ; DR Q8K2I1, FNTB_MOUSE ; Q04903, FNTB_PEA ; G4MY67, FNTB_PYRO7 ; DR Q02293, FNTB_RAT ; O13782, FNTB_SCHPO ; P22007, FNTB_YEAST ; //