ID   2.5.1.59
DE   protein geranylgeranyltransferase type I.
AN   GGTaseI.
AN   GGTase-I.
AN   type I protein geranyl-geranyltransferase.
CA   geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate +
CA   S-geranylgeranyl-L-cysteinyl-[protein].
CC   -!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.60, constitutes the
CC       protein prenyltransferase family of enzymes.
CC   -!- Catalyzes the formation of a thioether linkage between the C-1 atom
CC       of the geranylgeranyl group and a cysteine residue fourth from the
CC       C-terminus of the protein.
CC   -!- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
CC       where the terminal residue, X, is preferably leucine; serine,
CC       methionine, alanine or glutamine makes the protein a substrate for
CC       EC 2.5.1.58.
CC   -!- The enzymes are relaxed in specificity for A(1), but cannot act if
CC       A(2) is aromatic.
CC   -!- Known targets of this enzyme include most gamma-subunits of
CC       heterotrimeric G proteins and Ras-related GTPases such as members of
CC       the Ras and Rac/Rho families.
CC   -!- The Zn(2+) is required for peptide, but not for isoprenoid, substrate
CC       binding.
DR   Q9LX33, FNTA_ARATH ;  P29702, FNTA_BOVIN ;  Q9Y765, FNTA_CANAX ;
DR   Q54RT9, FNTA_DICDI ;  P49354, FNTA_HUMAN ;  Q61239, FNTA_MOUSE ;
DR   O24304, FNTA_PEA   ;  Q04631, FNTA_RAT   ;  O60052, FNTA_SCHPO ;
DR   P93227, FNTA_SOLLC ;  P29703, FNTA_YEAST ;  O80642, PGTB1_ARATH;
DR   Q5EAD5, PGTB1_BOVIN;  Q55DA3, PGTB1_DICDI;  P53609, PGTB1_HUMAN;
DR   Q8BUY9, PGTB1_MOUSE;  P53610, PGTB1_RAT  ;  P32434, PGTB1_SCHPO;
DR   P18898, PGTB1_YEAST;
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