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ENZYME

ENZYME entry: EC 2.5.1.74

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.74
Accepted Name
1,4-dihydroxy-2-naphthoate polyprenyltransferase
Reaction catalysed
an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate
Comment(s)
  • This enzyme catalyzes a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA).
  • The bacterial enzyme is an inner membrane protein, with the C-terminus located in the periplasm.
  • It is highly specific for DHNA but not for a specific length of the prenyl chain.
Cross-references
BRENDA2.5.1.74
EC2PDB2.5.1.74
ExplorEnz2.5.1.74
KEGG Ligand Database for Enzyme Nomenclature2.5.1.74
IUBMB Enzyme Nomenclature2.5.1.74
MEDLINEFind literature relating to 2.5.1.74
MetaCyc2.5.1.74
Rhea expert-curated reactions2.5.1.74
UniProtKB/Swiss-Prot
P39582, MENA_BACSUP32166, MENA_ECOLIP44739, MENA_HAEIN
P65651, MENA_MYCBOO07134, MENA_MYCLEP9WIP2, MENA_MYCTO
P9WIP3, MENA_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-