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ENZYME entry: EC 2.5.1.81

Accepted Name
Geranylfarnesyl diphosphate synthase.
Alternative Name(s)
FGPP synthase.
Reaction catalysed
Geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
Comment(s)
  • The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis.
  • It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate.
  • The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate.
  • The enzyme is involved in the biosynthesis of C(25)-C(25) membrane lipids.
  • Formerly EC 2.5.1.n2.
Cross-references
BRENDA2.5.1.81
EC2PDB2.5.1.81
ExplorEnz2.5.1.81
PRIAM enzyme-specific profiles2.5.1.81
KEGG Ligand Database for Enzyme Nomenclature2.5.1.81
IUBMB Enzyme Nomenclature2.5.1.81
IntEnz2.5.1.81
MEDLINEFind literature relating to 2.5.1.81
MetaCyc2.5.1.81
Rhea expert-curated reactions2.5.1.81
UniProtKB/Swiss-Prot
A0A0U3BRC5, GFDPS_LEUCN;  Q9UWR6, GFPS_AERPX;  Q8PYS1, GFPS_METMA;  
Q3IPL1, GFPS_NATPD;  A1C8C3, OBLA_ASPCL;  M2V8C1, OBLA_COCH5;  
A0A1V1FVQ6, OBLA_EMEVA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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