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ENZYME

ENZYME entry: EC 2.5.1.81

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.81
Accepted Name
geranylfarnesyl diphosphate synthase
Alternative Name(s)
FGPP synthase
Reaction catalysed
isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
Comment(s)
  • The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis.
  • It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate.
  • The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate.
  • The enzyme is involved in the biosynthesis of C25-C25 membrane lipids.
  • Formerly EC 2.5.1.n2.
Cross-references
BRENDA2.5.1.81
EC2PDB2.5.1.81
ExplorEnz2.5.1.81
KEGG Ligand Database for Enzyme Nomenclature2.5.1.81
IUBMB Enzyme Nomenclature2.5.1.81
MEDLINEFind literature relating to 2.5.1.81
MetaCyc2.5.1.81
Rhea expert-curated reactions2.5.1.81
UniProtKB/Swiss-Prot
P9WEP0, AUAS_ASPUTN4V6D4, BTCA_COLORA0A2Z6FZ31, BTCA_NEOBT
A0A169T193, EVAS_EMEVAA0A0P0ZD79, EVVS_EMEVAA0A0U3BRC5, GFDPS_LEUCN
Q9UWR6, GFPS_AERPXQ8PYS1, GFPS_METMAQ3IPL1, GFPS_NATPD
A1DN30, NFSS_NEOFIA0A0U5G0B1, OBLA_ASPCIA1C8C3, OBLA_ASPCL
M2V8C1, OBLA_COCH5A0A1V1FVQ6, OBLA_EMEVAA0A2Z6AQX7, PBSS_PENBI
A0A2Z6AQX6, PVPS_TALVEM2U578, TPCA_COCH5

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-