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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific).
Alternative Name(s)
Dehydrodolichyl diphosphate synthase 1.
Rer2p Z-prenyltransferase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55)
  • The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
  • The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
  • Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
  • Largest Srt1p products reach C(290).
  • The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120).
PRIAM enzyme-specific profiles2.5.1.87
KEGG Ligand Database for Enzyme Nomenclature2.5.1.87
IUBMB Enzyme Nomenclature2.5.1.87
MEDLINEFind literature relating to
P60478, DPDS_MYCBO;  P38119, DPDS_MYCLE;  A0R0S4, DPDS_MYCS2;  
Q03175, SRT1_YEAST;  Q9Y7K8, UPPS_SCHPO;  Q12063, UPPS_YEAST;  
O14171, YE54_SCHPO;  

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