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ENZYME

ENZYME entry: EC 2.5.1.88

Accepted Name
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
Reaction catalysed
  • (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate
  • (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate
  • (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate
Comment(s)
  • Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate.
  • Broad product specificity with the major product being dodecaprenyl diphosphate.
  • Synthesizes even C70 prenyl diphosphate as the maximum chain-length product.
Cross-references
BRENDA2.5.1.88
EC2PDB2.5.1.88
ExplorEnz2.5.1.88
PRIAM enzyme-specific profiles2.5.1.88
KEGG Ligand Database for Enzyme Nomenclature2.5.1.88
IUBMB Enzyme Nomenclature2.5.1.88
IntEnz2.5.1.88
MEDLINEFind literature relating to 2.5.1.88
MetaCyc2.5.1.88
Rhea expert-curated reactions2.5.1.88
UniProtKB/Swiss-Prot
Q47RM6, DPDP_THEFY

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