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ENZYME entry: EC 2.6.1.106

Accepted Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase.
Reaction catalysed
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate <=> dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme is involved in the biosynthesis of dTDP-alpha-D- desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin.
  • The reaction occurs in the reverse direction.
Cross-references
BRENDA2.6.1.106
EC2PDB2.6.1.106
ExplorEnz2.6.1.106
PRIAM enzyme-specific profiles2.6.1.106
KEGG Ligand Database for Enzyme Nomenclature2.6.1.106
IUBMB Enzyme Nomenclature2.6.1.106
IntEnz2.6.1.106
MEDLINEFind literature relating to 2.6.1.106
MetaCyc2.6.1.106
Rhea expert-curated reactions2.6.1.106
UniProtKB/Swiss-Prot
Q9ZGH4, DESV_STRVZ;  Q9F837, MEDII_MICMH;  

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