ENZYME entry: EC 2.6.1.106
| Accepted Name |
|---|
| dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase.
|
| Reaction catalysed |
|---|
| dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate <=> dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate |
| Cofactor(s) |
|---|
| Pyridoxal 5'-phosphate.
|
| Comment(s) |
|---|
- The enzyme is involved in the biosynthesis of dTDP-alpha-D-
desosamine, a sugar found in several bacterial macrolide antibiotics
including erythromycin, megalomicin A, mycinamicin II,
and oleandomycin.
- The reaction occurs in the reverse direction.
|
| Cross-references |
|---|
| BRENDA | 2.6.1.106 |
| EC2PDB | 2.6.1.106 |
| ExplorEnz | 2.6.1.106 |
| PRIAM enzyme-specific profiles | 2.6.1.106 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.106 |
| IUBMB Enzyme Nomenclature | 2.6.1.106 |
| IntEnz | 2.6.1.106 |
| MEDLINE | Find literature relating to 2.6.1.106 |
| MetaCyc | 2.6.1.106 |
| UniProtKB/Swiss-Prot |
|
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