ID   2.6.1.121
DE   8-amino-7-oxononanoate carboxylating dehydrogenase.
CA   (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-
CA   7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+).
CC   -!- The enzyme, which participates in biotin biosynthesis, is found in
CC       haloarchaea and some cyanobacteria.
CC   -!- It forms a conjugant between (7R,8S)-8-amino-7-oxononanoate and an
CC       internal lysine residue and catalyzes multiple reactions, including a
CC       reduction, a carboxylation of the epsilon-amino group of the lysine
CC       residue, and an oxidative cleavage of the conjugate to release
CC       (7R,8S)-8-amino-7-(carboxyamino)nonanoate.
CC   -!- During this process the lysine residue serves as an amino donor and
CC       is converted to (S)-2-amino-6-oxohexanoate, resulting in inactivation
CC       of the enzyme following a single turnover. cf. EC 2.6.1.105.
DR   I3R9K3, BIOU_HALMT ;  Q55650, BIOU_SYNY3 ;
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