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ENZYME

ENZYME entry: EC 2.6.1.16

Accepted Name
glutamine--fructose-6-phosphate transaminase (isomerizing)
Alternative Name(s)
D-fructose-6-phosphate amidotransferase
GlcN6P synthase
glucosamine-6-phosphate isomerase (glutamine-forming)
glucosamine-6-phosphate synthase
hexosephosphate aminotransferase
L-glutamine-D-fructose-6-phosphate amidotransferase
Reaction catalysed
D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate
Comment(s)
  • Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).
  • Formerly EC 5.3.1.19.
Cross-references
BRENDA2.6.1.16
EC2PDB2.6.1.16
ExplorEnz2.6.1.16
PRIAM enzyme-specific profiles2.6.1.16
KEGG Ligand Database for Enzyme Nomenclature2.6.1.16
IUBMB Enzyme Nomenclature2.6.1.16
IntEnz2.6.1.16
MEDLINEFind literature relating to 2.6.1.16
MetaCyc2.6.1.16
Rhea expert-curated reactions2.6.1.16
UniProtKB/Swiss-Prot
P53704, GFA1_CANALQ8SRI2, GFA1_ENCCUQ09740, GFA1_SCHPO
P14742, GFA1_YEASTQ9LIP9, GFAT1_ARATHQ7T6X6, GFAT_MIMIV
Q06210, GFPT1_HUMANP47856, GFPT1_MOUSEP82808, GFPT1_RAT
Q08DQ2, GFPT2_BOVINO94808, GFPT2_HUMANQ9Z2Z9, GFPT2_MOUSE
Q4KMC4, GFPT2_RATQ6F6U8, GLMS_ACIADQ56275, GLMS_ACIFI
Q9YCQ6, GLMS_AERPEQ8UEH1, GLMS_AGRFCQ5E279, GLMS_ALIF1
Q5WLG7, GLMS_ALKCKO66648, GLMS_AQUAEQ81VN5, GLMS_BACAN
Q73F49, GLMS_BACC1Q81J01, GLMS_BACCRQ6HPL2, GLMS_BACHK
Q65P46, GLMS_BACLDE0U070, GLMS_BACSHP0CI73, GLMS_BACSU
Q8AAB1, GLMS_BACTNQ6G322, GLMS_BARHEQ6FZH6, GLMS_BARQU
Q7WE36, GLMS_BORBRQ7W334, GLMS_BORPAQ7VRZ3, GLMS_BORPE
P59362, GLMS_BRADUQ577Y1, GLMS_BRUABQ8YC47, GLMS_BRUME
Q8CY30, GLMS_BRUSUP57138, GLMS_BUCAIQ8KA75, GLMS_BUCAP
P59499, GLMS_BUCBPQ8R841, GLMS_CALS4Q9PMT4, GLMS_CAMJE
Q9ABV2, GLMS_CAUVCQ5L589, GLMS_CHLABQ821Z7, GLMS_CHLCV
Q9PLA4, GLMS_CHLMUQ9Z6U0, GLMS_CHLPNQ8KG38, GLMS_CHLTE
O84823, GLMS_CHLTRQ97MN6, GLMS_CLOABQ8XHZ7, GLMS_CLOPE
Q890U2, GLMS_CLOTEQ6NG33, GLMS_CORDIQ8FNH2, GLMS_COREF
Q8NND3, GLMS_CORGLO19908, GLMS_CYACAQ8XEG2, GLMS_ECO57
Q8FBT4, GLMS_ECOL6P17169, GLMS_ECOLIQ5NHQ9, GLMS_FRATT
Q8RG65, GLMS_FUSNNQ5L3P0, GLMS_GEOKAQ74GH6, GLMS_GEOSL
Q7NIG8, GLMS_GLOVIQ5FUY5, GLMS_GLUOXQ7VKK4, GLMS_HAEDU
P44708, GLMS_HAEINQ9KG45, GLMS_HALH5Q9HT00, GLMS_HALSA
Q9ZJ94, GLMS_HELPJO26060, GLMS_HELPYQ5QZH5, GLMS_IDILO
Q9CGT6, GLMS_LACLAQ88YE7, GLMS_LACPLQ5X153, GLMS_LEGPA
Q5ZRP4, GLMS_LEGPHQ5WSX8, GLMS_LEGPLQ6AD32, GLMS_LEIXX
Q72V57, GLMS_LEPICQ8EZQ1, GLMS_LEPINQ92DS8, GLMS_LISIN
Q722H1, GLMS_LISMFQ8Y915, GLMS_LISMOQ8TLL3, GLMS_METAC
Q58815, GLMS_METJAQ8TZ14, GLMS_METKAQ8Q038, GLMS_METMA
Q6LWM9, GLMS_METMPO26273, GLMS_METTHP0A589, GLMS_MYCBO
P40831, GLMS_MYCLEQ73S23, GLMS_MYCPAO68956, GLMS_MYCS2
P9WN48, GLMS_MYCTOP9WN49, GLMS_MYCTUQ5F584, GLMS_NEIG1
Q9JWN9, GLMS_NEIMAQ9K1P9, GLMS_NEIMBO68280, GLMS_NOSS9
Q8ETM5, GLMS_OCEIHP57963, GLMS_PASMUQ6CYJ9, GLMS_PECAS
Q7NA97, GLMS_PHOLLQ6LLH3, GLMS_PHOPRQ9HT25, GLMS_PSEAE
Q88BX8, GLMS_PSEPKQ87TT8, GLMS_PSESMQ9V249, GLMS_PYRAB
Q8ZTZ0, GLMS_PYRAEQ8U4D1, GLMS_PYRFUO57981, GLMS_PYRHO
Q8Y303, GLMS_RALN1Q98LX5, GLMS_RHILOQ92PS4, GLMS_RHIME
Q5PKV9, GLMS_SALPAQ8Z2Q2, GLMS_SALTIQ8ZKX1, GLMS_SALTY
Q8CX33, GLMS_SHEONQ83IY4, GLMS_SHIFLQ56206, GLMS_SPHYA
Q5HE49, GLMS_STAACP64227, GLMS_STAAMP64228, GLMS_STAAN
Q6GES3, GLMS_STAARQ6G7F8, GLMS_STAASQ8NVE6, GLMS_STAAW
Q5HM69, GLMS_STAEQQ8CRL1, GLMS_STAESQ8E5P8, GLMS_STRA3
Q8DZZ7, GLMS_STRA5O86781, GLMS_STRCOQ8DTY0, GLMS_STRMU
Q99ZD3, GLMS_STRP1P0DB32, GLMS_STRP3Q5XBV6, GLMS_STRP6
Q8P0S7, GLMS_STRP8Q97SQ9, GLMS_STRPNP0DB33, GLMS_STRPQ
Q8DRA8, GLMS_STRR6Q4J6D9, GLMS_SULACF9VPA4, GLMS_SULTO
Q67T12, GLMS_SYMTHP72720, GLMS_SYNY3Q5JH71, GLMS_THEKO
Q9WXZ5, GLMS_THEMAQ72HF4, GLMS_THET2Q56213, GLMS_THET8
Q8DJI6, GLMS_THEVBO83833, GLMS_TREPAQ83IA1, GLMS_TROW8
Q83FU2, GLMS_TROWTQ9KUM8, GLMS_VIBCHQ87SR3, GLMS_VIBPA
Q8DEF3, GLMS_VIBVUQ7MP62, GLMS_VIBVYQ8D3J0, GLMS_WIGBR
Q8PGH9, GLMS_XANACQ8PCY1, GLMS_XANCPQ9PH05, GLMS_XYLFA
Q87F28, GLMS_XYLFTQ8Z9S8, GLMS_YERPEQ663R1, GLMS_YERPS
Q5NRH4, GLMS_ZYMMOP94323, NODM_BRADUQ52846, NODM_RHILT
P08633, NODM_RHILVQ92ZK3, NODM_RHIMEP25195, NODM_RHIML
B3LLX6, YM084_YEAS1C7GL41, YM084_YEAS2A6ZME2, YM084_YEAS7
C8ZET7, YM084_YEAS8A2P2R3, YM084_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-