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ENZYME entry: EC 2.6.1.19

Accepted Name
4-aminobutyrate--2-oxoglutarate transaminase.
Alternative Name(s)
4-aminobutyrate aminotransferase.
beta-alanine--oxoglutarate aminotransferase.
GABA transaminase.
gamma-amino-N-butyrate transaminase.
Reaction catalysed
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde
Comment(s)
  • Requires pyridoxal phosphate.
  • Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. cf. EC 2.6.1.120.
Cross-references
BRENDA2.6.1.19
EC2PDB2.6.1.19
ExplorEnz2.6.1.19
PRIAM enzyme-specific profiles2.6.1.19
KEGG Ligand Database for Enzyme Nomenclature2.6.1.19
IUBMB Enzyme Nomenclature2.6.1.19
IntEnz2.6.1.19
MEDLINEFind literature relating to 2.6.1.19
MetaCyc2.6.1.19
Rhea expert-curated reactions2.6.1.19
UniProtKB/Swiss-Prot
P14010, GABAT_EMENI;  Q6CJ86, GABAT_KLULA;  O13837, GABAT_SCHPO;  
P49604, GABAT_USTMA;  P17649, GABAT_YEAST;  P94427, GABT_BACSU;  
Q9BGI0, GABT_BOVIN;  Q21217, GABT_CAEEL;  Q55FI1, GABT_DICDI;  
P22256, GABT_ECOLI;  P80404, GABT_HUMAN;  P61922, GABT_MOUSE;  
P63505, GABT_MYCBO;  P40829, GABT_MYCLE;  P9WQ78, GABT_MYCTO;  
P9WQ79, GABT_MYCTU;  P80147, GABT_PIG;  P50554, GABT_RAT;  
P50457, PUUE_ECOLI;  

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