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ENZYME entry: EC 2.6.1.21

Accepted Name
D-amino-acid transaminase.
Alternative Name(s)
D-alanine aminotransferase.
D-alanine transaminase.
D-alanine-D-glutamate transaminase.
D-amino acid aminotransferase.
D-amino acid transaminase.
D-aspartate aminotransferase.
D-aspartate transaminase.
D-aspartic aminotransferase.
Reaction catalysed
D-alanine + 2-oxoglutarate <=> pyruvate + D-glutamate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors.
  • It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best.
  • The enzyme from some other sources has a broader specificity.
  • Formerly EC 2.6.1.10.
Cross-references
PROSITEPDOC00618
BRENDA2.6.1.21
EC2PDB2.6.1.21
ExplorEnz2.6.1.21
PRIAM enzyme-specific profiles2.6.1.21
KEGG Ligand Database for Enzyme Nomenclature2.6.1.21
IUBMB Enzyme Nomenclature2.6.1.21
IntEnz2.6.1.21
MEDLINEFind literature relating to 2.6.1.21
MetaCyc2.6.1.21
Rhea expert-curated reactions2.6.1.21
UniProtKB/Swiss-Prot
Q8L493, DAAA_ARATH;  P54692, DAAA_BACLI;  O07597, DAAA_BACSU;  
P19938, DAAA_BACYM;  Q92B90, DAAA_LISIN;  G2JZ74, DAAA_LISM4;  
Q71Z49, DAAA_LISMF;  P0DJL9, DAAA_LISMO;  P54693, DAAA_LYSSH;  
Q5HF24, DAAA_STAAC;  P63511, DAAA_STAAM;  P99090, DAAA_STAAN;  
Q6GFV1, DAAA_STAAR;  Q6G8H7, DAAA_STAAS;  Q8NW24, DAAA_STAAW;  
Q5HNG0, DAAA_STAEQ;  Q8CS41, DAAA_STAES;  P54694, DAAA_STAHA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
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