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ENZYME

ENZYME entry: EC 2.6.1.52

Accepted Name
phosphoserine transaminase
Alternative Name(s)
3-phosphoserine aminotransferase
3PHP transaminase
hydroxypyruvic phosphate--glutamic transaminase
L-phosphoserine aminotransferase
phosphohydroxypyruvate transaminase
phosphohydroxypyruvic--glutamic transaminase
phosphoserine aminotransferase
PSAT
Reaction catalysed
  • 2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate
  • 2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • This enzyme catalyzes the second step in the phosphorylated pathway of serine biosynthesis and the third step in pyridoxal 5'-phosphate biosynthesis in the bacterium Escherichia coli.
  • Pyridoxal 5'-phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.
  • Non-phosphorylated forms of serine and threonine are not substrates.
  • The archaeal enzyme has a relaxed specificity and can act on L-cysteate and L-alanine as alternative substrates to O-phospho-L- serine.
Cross-references
BRENDA2.6.1.52
EC2PDB2.6.1.52
ExplorEnz2.6.1.52
PRIAM enzyme-specific profiles2.6.1.52
KEGG Ligand Database for Enzyme Nomenclature2.6.1.52
IUBMB Enzyme Nomenclature2.6.1.52
IntEnz2.6.1.52
MEDLINEFind literature relating to 2.6.1.52
MetaCyc2.6.1.52
Rhea expert-curated reactions2.6.1.52
UniProtKB/Swiss-Prot
Q96255, SERB1_ARATHQ9SHP0, SERB2_ARATHA1TSA3, SERC_ACIAC
Q6F961, SERC_ACIADB7GY87, SERC_ACIB3B7I5D6, SERC_ACIB5
B2HWW3, SERC_ACIBCA3M7Z0, SERC_ACIBTB7J6V1, SERC_ACIF2
B5EPR5, SERC_ACIF5Q21Y51, SERC_ALBFTQ5E6F2, SERC_ALIF1
B5FCJ8, SERC_ALIFMQ9RME2, SERC_ALKALQ5WHT9, SERC_ALKCK
Q5P7U7, SERC_AROAEB6YQL2, SERC_AZOPCC1DRQ9, SERC_AZOVD
C3P210, SERC_BACAAQ734W9, SERC_BACC1Q81BC0, SERC_BACCR
Q638W1, SERC_BACCZQ5LDN9, SERC_BACFNQ64UR4, SERC_BACFR
Q6HGI0, SERC_BACHKP80862, SERC_BACSUQ8A8L4, SERC_BACTN
Q1LTL2, SERC_BAUCHQ7VR40, SERC_BLOFLQ492S5, SERC_BLOPB
Q2L2T1, SERC_BORA1Q7WGU2, SERC_BORBRQ7W5Z9, SERC_BORPA
A9IJI3, SERC_BORPDQ7VZG4, SERC_BORPEB8D9A2, SERC_BUCA5
P57397, SERC_BUCAIP81435, SERC_BUCAPB8D7K4, SERC_BUCAT
P59492, SERC_BUCBPQ057N5, SERC_BUCCCB1YV30, SERC_BURA4
A0K5L8, SERC_BURCHB4EB45, SERC_BURCJQ0BH96, SERC_BURCM
Q39IG4, SERC_BURL3A9ADV9, SERC_BURM1B1JXR6, SERC_BURO0
Q1BY31, SERC_BURO1A4JCH1, SERC_BURVGP91856, SERC_CAEEL
A8FKB5, SERC_CAMJ8A7H543, SERC_CAMJDQ9PIH3, SERC_CAMJE
A1VY45, SERC_CAMJJQ5HWE5, SERC_CAMJRB9KDM7, SERC_CAMLR
Q7NVP1, SERC_CHRVOA8AIH6, SERC_CITK8A4QCG9, SERC_CORGB
B6J893, SERC_COXB1B6J1E0, SERC_COXB2A9KCT6, SERC_COXBN
A9NC17, SERC_COXBRQ83E12, SERC_COXBUA7MES8, SERC_CROS8
A9BM04, SERC_DELASB8FLC3, SERC_DESALA9A0A5, SERC_DESOH
Q6ALW3, SERC_DESPSQ55CQ6, SERC_DICDIA5EV80, SERC_DICNV
Q9VAN0, SERC_DROMEA7ZJZ6, SERC_ECO24B7UMZ3, SERC_ECO27
B7MHL6, SERC_ECO45B7LD99, SERC_ECO55Q8XEA7, SERC_ECO57
B5YT41, SERC_ECO5EB7NM68, SERC_ECO7IB7MS22, SERC_ECO81
B7M835, SERC_ECO8AC4ZQ33, SERC_ECOBWB1X847, SERC_ECODH
A7ZYL0, SERC_ECOHSA1A9I4, SERC_ECOK1Q0TJE6, SERC_ECOL5
Q8FJB7, SERC_ECOL6B1IW24, SERC_ECOLCP23721, SERC_ECOLI
B7NAQ6, SERC_ECOLUB6I8X9, SERC_ECOSEB1LJV7, SERC_ECOSM
Q1RDV1, SERC_ECOUTQ9X4H1, SERC_EDWI9A4W8S7, SERC_ENT38
B2VC80, SERC_ERWT9B7LN70, SERC_ESCF3C4L432, SERC_EXISA
A5FH28, SERC_FLAJ1A6GXC2, SERC_FLAPJQ5L296, SERC_GEOKA
Q7VLP0, SERC_HAEDUP44336, SERC_HAEINQ0I322, SERC_HAES1
Q2SCF2, SERC_HAHCHQ9KDM4, SERC_HALH5C4K3B1, SERC_HAMD5
A9B6Q3, SERC_HERA2A4G865, SERC_HERARQ9Y617, SERC_HUMAN
Q5QZ48, SERC_IDILOA6T1G7, SERC_JANMAB5XY88, SERC_KLEP3
A6T700, SERC_KLEP7A8YW78, SERC_LACH4Q9CHW5, SERC_LACLA
A2RIS2, SERC_LACLMQ031D5, SERC_LACLSQ88ZU5, SERC_LACPL
C1D8N3, SERC_LARHHQ5X5E7, SERC_LEGPAA5IBR0, SERC_LEGPC
Q5ZVM2, SERC_LEGPHQ5WWT0, SERC_LEGPLB0SCE2, SERC_LEPBA
B0SKW4, SERC_LEPBPQ72VI2, SERC_LEPICQ8F930, SERC_LEPIN
Q03W65, SERC_LEUMMB2GBS2, SERC_LIMF3Q926T3, SERC_LISIN
Q71VT6, SERC_LISMFQ8Y3L0, SERC_LISMOB1HSU6, SERC_LYSSC
Q65S80, SERC_MANSMA6VZ92, SERC_MARMSQ8TNI1, SERC_METAC
P52878, SERC_METBFQ8PT12, SERC_METMAQ99K85, SERC_MOUSE
A0QBI3, SERC_MYCA1P63515, SERC_MYCBOO33062, SERC_MYCLE
Q742L2, SERC_MYCPAA3Q635, SERC_MYCSJA1ULN4, SERC_MYCSK
Q1B3G6, SERC_MYCSSP9WQ72, SERC_MYCTOP9WQ73, SERC_MYCTU
A1TF55, SERC_MYCVPQ1D2L9, SERC_MYXXDQ5F7A0, SERC_NEIG1
O34370, SERC_NEIMAP57007, SERC_NEIMBA1KV48, SERC_NEIMF
Q59196, SERC_NIACIQ820S0, SERC_NITEUA1SEM0, SERC_NOCSJ
A6L9B7, SERC_PARD8B2JF00, SERC_PARP8B2T637, SERC_PARPJ
P57881, SERC_PASMUQ6D400, SERC_PECASC6DF64, SERC_PECCP
Q7N6D6, SERC_PHOLLQ6LPD9, SERC_PHOPRA6L5A6, SERC_PHOV8
A1VR16, SERC_POLNAQ12CL3, SERC_POLSJB2RID6, SERC_PORG3
Q7MV30, SERC_PORGIB4ET24, SERC_PROMHA6V2Q8, SERC_PSEA7
B7V9J9, SERC_PSEA8Q02PX3, SERC_PSEABQ9HZ66, SERC_PSEAE
Q1IDA2, SERC_PSEE4C3K6J5, SERC_PSEFSA4XTE7, SERC_PSEMY
Q88M07, SERC_PSEPKQ885T5, SERC_PSESMQ3ILA3, SERC_PSET1
Q4ZQ94, SERC_PSEU2P10658, SERC_RABITB2U882, SERC_RALPJ
Q8Y0Z0, SERC_RALSOQ7UQL3, SERC_RHOBAQ0S6R3, SERC_RHOJR
C1ATN6, SERC_RHOOBA1AWS0, SERC_RUTMCB5F159, SERC_SALA4
A9MHX6, SERC_SALARQ57R24, SERC_SALCHB5FQ49, SERC_SALDC
B5QYQ7, SERC_SALEPB5R8J4, SERC_SALG2P62676, SERC_SALGL
B4TD37, SERC_SALHSB4T141, SERC_SALNSA9N7V7, SERC_SALPB
C0PXU3, SERC_SALPCB4TRT8, SERC_SALSVP62677, SERC_SALTI
P55900, SERC_SALTYQ10349, SERC_SCHPOA8GCH0, SERC_SERP5
A1S6D1, SERC_SHEAMB8EA90, SERC_SHEB2A3D4A1, SERC_SHEB5
A6WNN5, SERC_SHEB8A9L2Y2, SERC_SHEB9Q12MU6, SERC_SHEDO
Q081U0, SERC_SHEFNB0TT41, SERC_SHEHHQ8EEH2, SERC_SHEON
A8H4A2, SERC_SHEPAA4Y757, SERC_SHEPCB8CMG9, SERC_SHEPW
A0KWN5, SERC_SHESAA8FVN8, SERC_SHESHQ0HIX3, SERC_SHESM
Q0HV09, SERC_SHESRA1RJD3, SERC_SHESWB1KF45, SERC_SHEWM
B2TUH4, SERC_SHIB3Q31YU4, SERC_SHIBSQ32E24, SERC_SHIDS
Q83LP3, SERC_SHIFLQ3Z3L5, SERC_SHISSQ2NUB0, SERC_SODGM
P52877, SERC_SPIOLQ8E3Y3, SERC_STRA3B4SP45, SERC_STRM5
B2FKF0, SERC_STRMKQ8DSV3, SERC_STRMUA4W0D4, SERC_STRS2
A3CPJ2, SERC_STRSVA4VU42, SERC_STRSYQ5LYP0, SERC_STRT1
Q5M3A4, SERC_STRT2Q03JH6, SERC_STRTDB9DTW4, SERC_STRU0
Q9RI02, SERC_STUSTA0LK14, SERC_SYNFMQ3SK88, SERC_THIDA
A5CWI0, SERC_VESOHQ9KSU7, SERC_VIBCHQ87QA3, SERC_VIBPA
Q8D900, SERC_VIBVUQ7MLH6, SERC_VIBVYQ8D268, SERC_WIGBR
Q8PLY7, SERC_XANACQ3BUZ3, SERC_XANC5Q4UTC9, SERC_XANC8
B0RUW3, SERC_XANCBQ8PA97, SERC_XANCPQ2P354, SERC_XANOM
B2SJJ1, SERC_XANOPQ5H079, SERC_XANORQ8RLW0, SERC_XENNA
Q9PB19, SERC_XYLFAQ87BU0, SERC_XYLFTP33330, SERC_YEAST
P19689, SERC_YERE8A7FJX0, SERC_YERP3Q1CA74, SERC_YERPA
B2KA22, SERC_YERPBQ8ZGB4, SERC_YERPEA9R7I1, SERC_YERPG
A4TN19, SERC_YERPPQ66CI9, SERC_YERPSB1JRE0, SERC_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-