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ENZYME

ENZYME entry: EC 2.6.1.52

Accepted Name
phosphoserine transaminase
Alternative Name(s)
3-phosphoserine aminotransferase
3PHP transaminase
hydroxypyruvic phosphate--glutamic transaminase
L-phosphoserine aminotransferase
phosphohydroxypyruvate transaminase
phosphohydroxypyruvic--glutamic transaminase
phosphoserine aminotransferase
PSAT
Reaction catalysed
  • 2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate
  • 2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • This enzyme catalyzes the second step in the phosphorylated pathway of serine biosynthesis and the third step in pyridoxal 5'-phosphate biosynthesis in the bacterium Escherichia coli.
  • Pyridoxal 5'-phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.
  • Non-phosphorylated forms of serine and threonine are not substrates.
  • The archaeal enzyme has a relaxed specificity and can act on L-cysteate and L-alanine as alternative substrates to O-phospho-L- serine.
Cross-references
BRENDA2.6.1.52
EC2PDB2.6.1.52
ExplorEnz2.6.1.52
PRIAM enzyme-specific profiles2.6.1.52
KEGG Ligand Database for Enzyme Nomenclature2.6.1.52
IUBMB Enzyme Nomenclature2.6.1.52
IntEnz2.6.1.52
MEDLINEFind literature relating to 2.6.1.52
MetaCyc2.6.1.52
Rhea expert-curated reactions2.6.1.52
UniProtKB/Swiss-Prot
Q96255, SERB1_ARATHQ9SHP0, SERB2_ARATHQ6F961, SERC_ACIAD
B7GY87, SERC_ACIB3B7I5D6, SERC_ACIB5B2HWW3, SERC_ACIBC
A3M7Z0, SERC_ACIBTB7J6V1, SERC_ACIF2B5EPR5, SERC_ACIF5
Q21Y51, SERC_ALBFTQ5E6F2, SERC_ALIF1B5FCJ8, SERC_ALIFM
Q9RME2, SERC_ALKALQ5P7U7, SERC_AROAEB6YQL2, SERC_AZOPC
C1DRQ9, SERC_AZOVDC3P210, SERC_BACAAQ734W9, SERC_BACC1
Q81BC0, SERC_BACCRQ638W1, SERC_BACCZQ5LDN9, SERC_BACFN
Q64UR4, SERC_BACFRQ6HGI0, SERC_BACHKP80862, SERC_BACSU
Q8A8L4, SERC_BACTNQ1LTL2, SERC_BAUCHQ7VR40, SERC_BLOFL
Q492S5, SERC_BLOPBQ2L2T1, SERC_BORA1Q7WGU2, SERC_BORBR
Q7W5Z9, SERC_BORPAA9IJI3, SERC_BORPDQ7VZG4, SERC_BORPE
B8D9A2, SERC_BUCA5P57397, SERC_BUCAIP81435, SERC_BUCAP
B8D7K4, SERC_BUCATP59492, SERC_BUCBPQ057N5, SERC_BUCCC
B1YV30, SERC_BURA4A0K5L8, SERC_BURCHB4EB45, SERC_BURCJ
Q0BH96, SERC_BURCMQ39IG4, SERC_BURL3A9ADV9, SERC_BURM1
B1JXR6, SERC_BURO0Q1BY31, SERC_BURO1A4JCH1, SERC_BURVG
P91856, SERC_CAEELA8FKB5, SERC_CAMJ8A7H543, SERC_CAMJD
Q9PIH3, SERC_CAMJEA1VY45, SERC_CAMJJQ5HWE5, SERC_CAMJR
B9KDM7, SERC_CAMLRQ7NVP1, SERC_CHRVOA8AIH6, SERC_CITK8
A4QCG9, SERC_CORGBB6J893, SERC_COXB1B6J1E0, SERC_COXB2
A9KCT6, SERC_COXBNA9NC17, SERC_COXBRQ83E12, SERC_COXBU
A7MES8, SERC_CROS8A9BM04, SERC_DELASB8FLC3, SERC_DESAL
A9A0A5, SERC_DESOHQ6ALW3, SERC_DESPSQ55CQ6, SERC_DICDI
A5EV80, SERC_DICNVQ9VAN0, SERC_DROMEA7ZJZ6, SERC_ECO24
B7UMZ3, SERC_ECO27B7MHL6, SERC_ECO45B7LD99, SERC_ECO55
Q8XEA7, SERC_ECO57B5YT41, SERC_ECO5EB7NM68, SERC_ECO7I
B7MS22, SERC_ECO81B7M835, SERC_ECO8AC4ZQ33, SERC_ECOBW
B1X847, SERC_ECODHA7ZYL0, SERC_ECOHSA1A9I4, SERC_ECOK1
Q0TJE6, SERC_ECOL5Q8FJB7, SERC_ECOL6B1IW24, SERC_ECOLC
P23721, SERC_ECOLIB7NAQ6, SERC_ECOLUB6I8X9, SERC_ECOSE
B1LJV7, SERC_ECOSMQ1RDV1, SERC_ECOUTQ9X4H1, SERC_EDWI9
A4W8S7, SERC_ENT38B2VC80, SERC_ERWT9B7LN70, SERC_ESCF3
C4L432, SERC_EXISAA5FH28, SERC_FLAJ1A6GXC2, SERC_FLAPJ
Q5L296, SERC_GEOKAQ7VLP0, SERC_HAEDUP44336, SERC_HAEIN
Q2SCF2, SERC_HAHCHQ9KDM4, SERC_HALH5C4K3B1, SERC_HAMD5
A9B6Q3, SERC_HERA2A4G865, SERC_HERARQ0I322, SERC_HISS1
Q9Y617, SERC_HUMANQ5QZ48, SERC_IDILOA6T1G7, SERC_JANMA
B5XY88, SERC_KLEP3A6T700, SERC_KLEP7A8YW78, SERC_LACH4
Q9CHW5, SERC_LACLAA2RIS2, SERC_LACLMQ031D5, SERC_LACLS
Q88ZU5, SERC_LACPLC1D8N3, SERC_LARHHQ5X5E7, SERC_LEGPA
A5IBR0, SERC_LEGPCQ5ZVM2, SERC_LEGPHQ5WWT0, SERC_LEGPL
B0SCE2, SERC_LEPBAB0SKW4, SERC_LEPBPQ72VI2, SERC_LEPIC
Q8F930, SERC_LEPINQ03W65, SERC_LEUMMB2GBS2, SERC_LIMF3
Q926T3, SERC_LISINQ71VT6, SERC_LISMFQ8Y3L0, SERC_LISMO
B1HSU6, SERC_LYSSCQ65S80, SERC_MANSMA6VZ92, SERC_MARMS
Q8TNI1, SERC_METACP52878, SERC_METBFQ8PT12, SERC_METMA
Q99K85, SERC_MOUSEA0QBI3, SERC_MYCA1P63515, SERC_MYCBO
O33062, SERC_MYCLEQ742L2, SERC_MYCPAA3Q635, SERC_MYCSJ
A1ULN4, SERC_MYCSKQ1B3G6, SERC_MYCSSP9WQ72, SERC_MYCTO
P9WQ73, SERC_MYCTUA1TF55, SERC_MYCVPQ1D2L9, SERC_MYXXD
Q5F7A0, SERC_NEIG1O34370, SERC_NEIMAP57007, SERC_NEIMB
A1KV48, SERC_NEIMFQ59196, SERC_NIACIQ820S0, SERC_NITEU
A1SEM0, SERC_NOCSJA1TSA3, SERC_PARC0A6L9B7, SERC_PARD8
B2JF00, SERC_PARP8B2T637, SERC_PARPJP57881, SERC_PASMU
Q6D400, SERC_PECASC6DF64, SERC_PECCPQ7N6D6, SERC_PHOLL
Q6LPD9, SERC_PHOPRA6L5A6, SERC_PHOV8A1VR16, SERC_POLNA
Q12CL3, SERC_POLSJB2RID6, SERC_PORG3Q7MV30, SERC_PORGI
B4ET24, SERC_PROMHA6V2Q8, SERC_PSEA7B7V9J9, SERC_PSEA8
Q02PX3, SERC_PSEABQ9HZ66, SERC_PSEAEQ1IDA2, SERC_PSEE4
C3K6J5, SERC_PSEFSA4XTE7, SERC_PSEMYQ88M07, SERC_PSEPK
Q885T5, SERC_PSESMQ3ILA3, SERC_PSET1Q4ZQ94, SERC_PSEU2
P10658, SERC_RABITQ8Y0Z0, SERC_RALN1B2U882, SERC_RALPJ
Q7UQL3, SERC_RHOBAQ0S6R3, SERC_RHOJRC1ATN6, SERC_RHOOB
A1AWS0, SERC_RUTMCB5F159, SERC_SALA4A9MHX6, SERC_SALAR
Q57R24, SERC_SALCHB5FQ49, SERC_SALDCB5QYQ7, SERC_SALEP
B5R8J4, SERC_SALG2P62676, SERC_SALGLB4TD37, SERC_SALHS
B4T141, SERC_SALNSA9N7V7, SERC_SALPBC0PXU3, SERC_SALPC
B4TRT8, SERC_SALSVP62677, SERC_SALTIP55900, SERC_SALTY
Q10349, SERC_SCHPOA8GCH0, SERC_SERP5A1S6D1, SERC_SHEAM
B8EA90, SERC_SHEB2A3D4A1, SERC_SHEB5A6WNN5, SERC_SHEB8
A9L2Y2, SERC_SHEB9Q12MU6, SERC_SHEDOQ081U0, SERC_SHEFN
B0TT41, SERC_SHEHHQ8EEH2, SERC_SHEONA8H4A2, SERC_SHEPA
A4Y757, SERC_SHEPCB8CMG9, SERC_SHEPWA0KWN5, SERC_SHESA
A8FVN8, SERC_SHESHQ0HIX3, SERC_SHESMQ0HV09, SERC_SHESR
A1RJD3, SERC_SHESWB1KF45, SERC_SHEWMB2TUH4, SERC_SHIB3
Q31YU4, SERC_SHIBSQ32E24, SERC_SHIDSQ83LP3, SERC_SHIFL
Q3Z3L5, SERC_SHISSQ5WHT9, SERC_SHOC1Q2NUB0, SERC_SODGM
P52877, SERC_SPIOLQ8E3Y3, SERC_STRA3B4SP45, SERC_STRM5
B2FKF0, SERC_STRMKQ8DSV3, SERC_STRMUA4W0D4, SERC_STRS2
A3CPJ2, SERC_STRSVA4VU42, SERC_STRSYQ5LYP0, SERC_STRT1
Q5M3A4, SERC_STRT2Q03JH6, SERC_STRTDB9DTW4, SERC_STRU0
Q9RI02, SERC_STUSTA0LK14, SERC_SYNFMQ3SK88, SERC_THIDA
A5CWI0, SERC_VESOHQ9KSU7, SERC_VIBCHQ87QA3, SERC_VIBPA
Q8D900, SERC_VIBVUQ7MLH6, SERC_VIBVYQ8D268, SERC_WIGBR
Q8PLY7, SERC_XANACQ4UTC9, SERC_XANC8B0RUW3, SERC_XANCB
Q8PA97, SERC_XANCPQ3BUZ3, SERC_XANE5Q2P354, SERC_XANOM
B2SJJ1, SERC_XANOPQ5H079, SERC_XANORQ8RLW0, SERC_XENNA
Q9PB19, SERC_XYLFAQ87BU0, SERC_XYLFTP33330, SERC_YEAST
P19689, SERC_YERE8A7FJX0, SERC_YERP3Q1CA74, SERC_YERPA
B2KA22, SERC_YERPBQ8ZGB4, SERC_YERPEA9R7I1, SERC_YERPG
A4TN19, SERC_YERPPQ66CI9, SERC_YERPSB1JRE0, SERC_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-