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ENZYME entry: EC 2.6.1.63

Accepted Name
kynurenine--glyoxylate transaminase.
Alternative Name(s)
kynurenine--glyoxylate aminotransferase.
Reaction catalysed
  • glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate
  • 3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate
Comment(s)
  • This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7).
  • The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3- hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
Cross-references
BRENDA2.6.1.63
EC2PDB2.6.1.63
ExplorEnz2.6.1.63
PRIAM enzyme-specific profiles2.6.1.63
KEGG Ligand Database for Enzyme Nomenclature2.6.1.63
IUBMB Enzyme Nomenclature2.6.1.63
IntEnz2.6.1.63
MEDLINEFind literature relating to 2.6.1.63
MetaCyc2.6.1.63
Rhea expert-curated reactions2.6.1.63
UniProtKB/Swiss-Prot
Q5E9N4, AADAT_BOVIN;  Q8N5Z0, AADAT_HUMAN;  Q9WVM8, AADAT_MOUSE;  
Q64602, AADAT_RAT;  Q0IG34, HKT_AEDAE;  Q7PRG3, HKT_ANOGA;  
Q0P5G4, KAT3_BOVIN;  Q7T3E5, KAT3_DANRE;  Q6YP21, KAT3_HUMAN;  
Q71RI9, KAT3_MOUSE;  Q58FK9, KAT3_RAT;  Q17CS8, KAT_AEDAE;  

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