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ENZYME entry: EC 2.6.1.97

Accepted Name
archaeosine synthase.
Reaction catalysed
7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate
Comment(s)
  • In Euryarchaeota the reaction is catalyzed by ArcS.
  • In Crenarchaeota, which do not have an ArcS homolog, the reaction is catalyzed either by a homolog of EC 6.3.4.20 that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homolog of EC 1.7.1.13.
  • The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.
Cross-references
BRENDA2.6.1.97
EC2PDB2.6.1.97
ExplorEnz2.6.1.97
PRIAM enzyme-specific profiles2.6.1.97
KEGG Ligand Database for Enzyme Nomenclature2.6.1.97
IUBMB Enzyme Nomenclature2.6.1.97
IntEnz2.6.1.97
MEDLINEFind literature relating to 2.6.1.97
MetaCyc2.6.1.97
Rhea expert-curated reactions2.6.1.97
UniProtKB/Swiss-Prot
D4GTN6, ARCS_HALVD;  Q58428, ARCS_METJA;  

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