ENZYME entry: EC 2.7.1.107

Accepted Name

diacylglycerol kinase (ATP)

Alternative Name(s)

DGK

diglyceride kinase

Reaction catalysed

a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Comment(s)

Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol.
Activity is stimulated by certain phospholipids.
In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174.

Cross-references

BRENDA

2.7.1.107

EC2PDB

2.7.1.107

ExplorEnz

2.7.1.107

PRIAM enzyme-specific profiles

2.7.1.107

KEGG Ligand Database for Enzyme Nomenclature

2.7.1.107

IUBMB Enzyme Nomenclature

2.7.1.107

IntEnz

2.7.1.107

MEDLINE

Find literature relating to 2.7.1.107

MetaCyc

2.7.1.107

Rhea expert-curated reactions

2.7.1.107

UniProtKB/Swiss-Prot

Q7ZW00, AGK_DANRE	Q53H12, AGK_HUMAN	Q9ESW4, AGK_MOUSE
Q5RED7, AGK_PONAB	Q7ZYJ3, AGK_XENLA	O31502, DAGK_BACSU
P9WP28, DAGK_MYCTO	P9WP29, DAGK_MYCTU	A7X424, DAGK_STAA1
A6U302, DAGK_STAA2	Q2FFJ7, DAGK_STAA3	Q2FWZ2, DAGK_STAA8
A5IU64, DAGK_STAA9	Q2YU29, DAGK_STAAB	Q5HEM4, DAGK_STAAC
A6QIC6, DAGK_STAAE	Q99SY8, DAGK_STAAM	Q7A4Q8, DAGK_STAAN
Q6GFF9, DAGK_STAAR	Q6G835, DAGK_STAAS	A8Z2R1, DAGK_STAAT
Q7A0H3, DAGK_STAAW	B9DMT6, DAGK_STACT	Q5HN36, DAGK_STAEQ
Q8CRU5, DAGK_STAES	Q4L7L1, DAGK_STAHJ	Q49YU2, DAGK_STAS1
Q39017, DGK1_ARATH	Q01583, DGK1_DROME	Q7XQT2, DGK1_ORYSJ
Q9FFN7, DGK2_ARATH	Q09103, DGK2_DROME	Q8VZG1, DGK3_ARATH
Q03603, DGK3_CAEEL	Q1PDI2, DGK4_ARATH	Q9C5E5, DGK5_ARATH
Q10024, DGK5_CAEEL	F4JKI3, DGK6_ARATH	F4JQ95, DGK7_ARATH
A0JN54, DGKA_BOVIN	P34125, DGKA_DICDI	P23743, DGKA_HUMAN
O88673, DGKA_MOUSE	P20192, DGKA_PIG	P51556, DGKA_RAT
Q9Y6T7, DGKB_HUMAN	Q6NS52, DGKB_MOUSE	P49621, DGKB_RAT
Q16760, DGKD_HUMAN	E9PUQ8, DGKD_MOUSE	P52429, DGKE_HUMAN
Q9R1C6, DGKE_MOUSE	P49619, DGKG_HUMAN	Q91WG7, DGKG_MOUSE
P49620, DGKG_RAT	B3LXF2, DGKH_DROAN	B3NYS4, DGKH_DROER
B4JHJ7, DGKH_DROGR	A8JQ65, DGKH_DROME	B4K6T8, DGKH_DROMO
B4I4Y1, DGKH_DROSE	B4R0A5, DGKH_DROSI	B4PRE2, DGKH_DROYA
Q86XP1, DGKH_HUMAN	Q64398, DGKH_MESAU	D3YXJ0, DGKH_MOUSE
O75912, DGKI_HUMAN	D3YWQ0, DGKI_MOUSE	F1MAB7, DGKI_RAT
Q5KSL6, DGKK_HUMAN	P52824, DGKQ_HUMAN	Q6P5E8, DGKQ_MOUSE
D3ZEY4, DGKQ_RAT	Q13574, DGKZ_HUMAN	Q80UP3, DGKZ_MOUSE
O08560, DGKZ_RAT	P0ABN3, KDGL_ECO57	P0ABN2, KDGL_ECOL6
P0ABN1, KDGL_ECOLI	P44424, KDGL_HAEIN	Q9ZLE0, KDGL_HELPJ
P56411, KDGL_HELPY	Q9HY23, KDGL_PSEAE	Q06119, KDGL_RHIME
P0ABN4, KDGL_SHIFL	P29945, KDGL_SINSX	Q55143, KDGL_SYNY3

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