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ENZYME entry: EC 2.7.1.153

Accepted Name
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
Alternative Name(s)
Type I phosphoinositide 3-kinase.
Reaction catalysed
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Comment(s)
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
Cross-references
BRENDA2.7.1.153
EC2PDB2.7.1.153
ExplorEnz2.7.1.153
PRIAM enzyme-specific profiles2.7.1.153
KEGG Ligand Database for Enzyme Nomenclature2.7.1.153
IUBMB Enzyme Nomenclature2.7.1.153
IntEnz2.7.1.153
MEDLINEFind literature relating to 2.7.1.153
MetaCyc2.7.1.153
Rhea expert-curated reactions2.7.1.153
UniProtKB/Swiss-Prot
Q8NFU5, IPMK_HUMAN;  Q7TT16, IPMK_MOUSE;  Q99NI4, IPMK_RAT;  
O00443, P3C2A_HUMAN;  Q61194, P3C2A_MOUSE;  Q5RAY1, P3C2A_PONAB;  
P32871, PK3CA_BOVIN;  P42336, PK3CA_HUMAN;  P42337, PK3CA_MOUSE;  
A0A0G2K344, PK3CA_RAT;  P42338, PK3CB_HUMAN;  Q8BTI9, PK3CB_MOUSE;  
Q9Z1L0, PK3CB_RAT;  O00329, PK3CD_HUMAN;  O35904, PK3CD_MOUSE;  
P48736, PK3CG_HUMAN;  Q9JHG7, PK3CG_MOUSE;  O02697, PK3CG_PIG;  

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