ENZYME entry: EC 2.7.1.153
| Accepted Name |
|---|
| phosphatidylinositol-4,5-bisphosphate 3-kinase.
|
| Alternative Name(s) |
|---|
| type I phosphoinositide 3-kinase. |
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) |
| Comment(s) |
|---|
| This enzyme also catalyzes the phosphorylation of PtdIns4P to
PtdIns(3,4)P2, and of PtdIns to PtdIns3P.
|
| Cross-references |
|---|
| BRENDA | 2.7.1.153 |
| EC2PDB | 2.7.1.153 |
| ExplorEnz | 2.7.1.153 |
| PRIAM enzyme-specific profiles | 2.7.1.153 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.153 |
| IUBMB Enzyme Nomenclature | 2.7.1.153 |
| IntEnz | 2.7.1.153 |
| MEDLINE | Find literature relating to 2.7.1.153 |
| MetaCyc | 2.7.1.153 |
| Rhea expert-curated reactions | 2.7.1.153 |
| UniProtKB/Swiss-Prot |
| Q8NFU5, IPMK_HUMAN; | Q7TT16, IPMK_MOUSE; | Q99NI4, IPMK_RAT; |
| O00443, P3C2A_HUMAN; | Q61194, P3C2A_MOUSE; | Q5RAY1, P3C2A_PONAB; |
| P32871, PK3CA_BOVIN; | P42336, PK3CA_HUMAN; | P42337, PK3CA_MOUSE; |
| A0A0G2K344, PK3CA_RAT; | P42338, PK3CB_HUMAN; | Q8BTI9, PK3CB_MOUSE; |
| Q9Z1L0, PK3CB_RAT; | O00329, PK3CD_HUMAN; | O35904, PK3CD_MOUSE; |
| P48736, PK3CG_HUMAN; | Q9JHG7, PK3CG_MOUSE; | O02697, PK3CG_PIG; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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