ID 2.7.1.171 DE Protein-fructosamine 3-kinase. AN Fructosamine 3-kinase. CA ATP + [protein]-N(6)-D-fructosyl-L-lysine = ADP + [protein]-N(6)-(3-O- CA phospho-D-fructosyl)-L-lysine. CC -!- Nonenzymatic glycation is an important factor in the pathogenesis of CC diabetic complications. CC -!- Key early intermediates in this process are fructosamines, such as CC [protein]-N(6)-D-fructosyl-L-lysine. CC -!- Fructosamine-3-kinase is part of an ATP-dependent system for removing CC carbohydrates from nonenzymatically glycated proteins. CC -!- The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L- CC lysine adduct and leads to its spontaneous decomposition. CC -!- Cf. EC 2.7.1.172. //