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ENZYME entry: EC 2.7.1.178

Accepted Name
2-dehydro-3-deoxyglucono/galactono-kinase.
Alternative Name(s)
2-keto-3-deoxy-D-gluconate kinase.
KDG kinase.
Reaction catalysed
  • 2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)
  • 2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)
Comment(s)
  • The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway.
  • It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with similar catalytic efficiency.
  • Cf. EC 2.7.1.45 and EC 2.7.1.58.
Cross-references
BRENDA2.7.1.178
EC2PDB2.7.1.178
ExplorEnz2.7.1.178
PRIAM enzyme-specific profiles2.7.1.178
KEGG Ligand Database for Enzyme Nomenclature2.7.1.178
IUBMB Enzyme Nomenclature2.7.1.178
IntEnz2.7.1.178
MEDLINEFind literature relating to 2.7.1.178
MetaCyc2.7.1.178
Rhea expert-curated reactions2.7.1.178
UniProtKB/Swiss-Prot
D4GSE6, KDGK1_HALVD;  Q97U29, KDGK_SACS2;  

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