ENZYME entry: EC 2.7.1.183
Accepted Name | ||||||||
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glycoprotein-mannosyl O(6)-kinase | ||||||||
Alternative Name(s) | ||||||||
protein O-mannose kinase | ||||||||
Reaction catalysed | ||||||||
3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) | ||||||||
Comment(s) | ||||||||
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity. | ||||||||
Cross-references | ||||||||
BRENDA | 2.7.1.183 | |||||||
EC2PDB | 2.7.1.183 | |||||||
ExplorEnz | 2.7.1.183 | |||||||
PRIAM enzyme-specific profiles | 2.7.1.183 | |||||||
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.183 | |||||||
IUBMB Enzyme Nomenclature | 2.7.1.183 | |||||||
IntEnz | 2.7.1.183 | |||||||
MEDLINE | Find literature relating to 2.7.1.183 | |||||||
MetaCyc | 2.7.1.183 | |||||||
Rhea expert-curated reactions | 2.7.1.183 | |||||||
UniProtKB/Swiss-Prot |
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