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ENZYME

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ENZYME entry: EC 2.7.1.183

Accepted Name
glycoprotein-mannosyl O(6)-kinase
Alternative Name(s)
protein O-mannose kinase
Reaction catalysed
3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)
Comment(s)
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
Cross-references
BRENDA2.7.1.183
EC2PDB2.7.1.183
ExplorEnz2.7.1.183
PRIAM enzyme-specific profiles2.7.1.183
KEGG Ligand Database for Enzyme Nomenclature2.7.1.183
IUBMB Enzyme Nomenclature2.7.1.183
IntEnz2.7.1.183
MEDLINEFind literature relating to 2.7.1.183
MetaCyc2.7.1.183
Rhea expert-curated reactions2.7.1.183
UniProtKB/Swiss-Prot
Q5F349, SG196_CHICKQ5U3W1, SG196_DANREQ9H5K3, SG196_HUMAN
Q95JJ0, SG196_MACFAQ3TUA9, SG196_MOUSEQ4V8A9, SG196_RAT
Q5HZP7, SG196_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-