ID   2.7.1.207
DE   protein-N(pi)-phosphohistidine--lactose phosphotransferase.
AN   lactose PTS permease.
CA   lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-
CA   [protein] + lactose 6-phosphate(in).
CC   -!- This enzyme is a component (known as enzyme II) of a
CC       phosphoenolpyruvate (PEP)-dependent, sugar transporting
CC       phosphotransferase system (PTS).
CC   -!- The system, which is found only in prokaryotes, simultaneously
CC       transports its substrate from the periplasm or extracellular space
CC       into the cytoplasm and phosphorylates it.
CC   -!- The phosphate donor, which is shared among the different systems,
CC       is a phospho-carrier protein of low molecular mass that has been
CC       phosphorylated by EC 2.7.3.9.
CC   -!- Enzyme II, on the other hand, is specific for a particular substrate,
CC       although in some cases alternative substrates can be transported with
CC       lower efficiency.
CC   -!- The reaction involves a successive transfer of the phosphate group to
CC       several amino acids within the enzyme before the final transfer to
CC       the substrate.
CC   -!- Formerly EC 2.7.1.69.
DR   P24400, PTLCB_LACCA;  P23531, PTLCB_LACLL;  Q5HE15, PTLCB_STAAC;
DR   Q931G6, PTLCB_STAAM;  Q99S77, PTLCB_STAAN;  Q6GEN9, PTLCB_STAAR;
DR   Q6G7C4, PTLCB_STAAS;  P11162, PTLCB_STAAU;  Q7A092, PTLCB_STAAW;
DR   Q5HM40, PTLCB_STAEQ;  Q8CNF7, PTLCB_STAES;  Q4L869, PTLCB_STAHJ;
DR   P50976, PTLCB_STRMU;
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