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ENZYME entry: EC 2.7.1.228

Accepted Name
Mannosyl-inositol-phosphoceramide inositolphosphotransferase.
Reaction catalysed
1-phosphatidyl-1D-myo-inositol + a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine <=> 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((6-O-(6-O-((1D-myo-inositol-1-O-yl)hydroxyphosphoryl)-alpha-D-mannosyl)-1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine
Comment(s)
  • This enzyme catalyzes the ultimate reaction in the yeast sphingolipid biosynthesis pathway.
  • It transfers a second phosphoinositol group to mannosyl-inositol- phospho-alpha-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).
Cross-references
BRENDA2.7.1.228
EC2PDB2.7.1.228
ExplorEnz2.7.1.228
PRIAM enzyme-specific profiles2.7.1.228
KEGG Ligand Database for Enzyme Nomenclature2.7.1.228
IUBMB Enzyme Nomenclature2.7.1.228
IntEnz2.7.1.228
MEDLINEFind literature relating to 2.7.1.228
MetaCyc2.7.1.228
Rhea expert-curated reactions2.7.1.228
UniProtKB/Swiss-Prot
P38954, IPT1_YEAST

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