| Accepted Name |
|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase.
|
| Alternative Name(s) |
|---|
| diphosphoinositide kinase. |
| phosphatidylinositol-4-phosphate 5-kinase. |
| phosphatidylinositol 4-phosphate kinase. |
| PIP kinase. |
| PtdIns(4)P-5-kinase. |
| type I PIP kinase. |
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) |
| Comment(s) |
|---|
- This enzyme can also phosphorylate PtdIns3P in the 4-position,
and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro,
but to a lesser extent.
- The last of these reactions occurs in vivo and is physiologically
relevant.
|
| Cross-references |
|---|
| BRENDA | 2.7.1.68 |
| EC2PDB | 2.7.1.68 |
| ExplorEnz | 2.7.1.68 |
| PRIAM enzyme-specific profiles | 2.7.1.68 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.68 |
| IUBMB Enzyme Nomenclature | 2.7.1.68 |
| IntEnz | 2.7.1.68 |
| MEDLINE | Find literature relating to 2.7.1.68 |
| MetaCyc | 2.7.1.68 |
| Rhea expert-curated reactions | 2.7.1.68 |
| UniProtKB/Swiss-Prot |
| O13853, ITS3_SCHPO; | P38994, MSS4_YEAST; | Q99755, PI51A_HUMAN; |
| P70182, PI51A_MOUSE; | D3ZSI8, PI51A_RAT; | Q5ZJ58, PI51B_CHICK; |
| O14986, PI51B_HUMAN; | P70181, PI51B_MOUSE; | Q5CZZ9, PI51B_RAT; |
| O60331, PI51C_HUMAN; | O70161, PI51C_MOUSE; | Q5I6B8, PI51C_RAT; |
| Q8I239, PI51N_PLAF7; | Q56YP2, PI5K1_ARATH; | Q6EX42, PI5K1_ORYSJ; |
| Q8L796, PI5K2_ARATH; | O48709, PI5K3_ARATH; | Q9M1K2, PI5K4_ARATH; |
| Q9SLG9, PI5K5_ARATH; | Q9SFB8, PI5K6_ARATH; | Q9SUI2, PI5K7_ARATH; |
| Q8RY89, PI5K8_ARATH; | Q8L850, PI5K9_ARATH; | Q9LMN1, PI5KA_ARATH; |
| Q9M149, PI5KB_ARATH; | Q17QS4, PI5L1_BOVIN; | Q5T9C9, PI5L1_HUMAN; |
|