ENZYME entry: EC 2.7.1.68

Accepted Name

1-phosphatidylinositol-4-phosphate 5-kinase

Alternative Name(s)

diphosphoinositide kinase

phosphatidylinositol-4-phosphate 5-kinase

phosphatidylinositol 4-phosphate kinase

PIP kinase

PtdIns(4)P-5-kinase

type I PIP kinase

Reaction catalysed

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Comment(s)

This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent.
The last of these reactions occurs in vivo and is physiologically relevant.

Cross-references

BRENDA

2.7.1.68

EC2PDB

2.7.1.68

ExplorEnz

2.7.1.68

PRIAM enzyme-specific profiles

2.7.1.68

KEGG Ligand Database for Enzyme Nomenclature

2.7.1.68

IUBMB Enzyme Nomenclature

2.7.1.68

IntEnz

2.7.1.68

MEDLINE

Find literature relating to 2.7.1.68

MetaCyc

2.7.1.68

Rhea expert-curated reactions

2.7.1.68

UniProtKB/Swiss-Prot

O13853, ITS3_SCHPO	P38994, MSS4_YEAST	Q99755, PI51A_HUMAN
P70182, PI51A_MOUSE	D3ZSI8, PI51A_RAT	Q5ZJ58, PI51B_CHICK
O14986, PI51B_HUMAN	P70181, PI51B_MOUSE	Q5CZZ9, PI51B_RAT
O60331, PI51C_HUMAN	O70161, PI51C_MOUSE	Q5I6B8, PI51C_RAT
Q8I239, PI51N_PLAF7	Q56YP2, PI5K1_ARATH	Q6EX42, PI5K1_ORYSJ
Q8L796, PI5K2_ARATH	O48709, PI5K3_ARATH	Q9M1K2, PI5K4_ARATH
Q9SLG9, PI5K5_ARATH	Q9SFB8, PI5K6_ARATH	Q9SUI2, PI5K7_ARATH
Q8RY89, PI5K8_ARATH	Q8L850, PI5K9_ARATH	Q9LMN1, PI5KA_ARATH
Q9M149, PI5KB_ARATH	Q17QS4, PI5L1_BOVIN	Q5T9C9, PI5L1_HUMAN

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