Accepted Name |
1-phosphatidylinositol-4-phosphate 5-kinase.
|
Alternative Name(s) |
Diphosphoinositide kinase. |
Phosphatidylinositol 4-phosphate kinase. |
Phosphatidylinositol-4-phosphate 5-kinase. |
PIP kinase. |
PtdIns(4)P-5-kinase. |
Type I PIP kinase. |
Reaction catalysed |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
Comment(s) |
- This enzyme can also phosphorylate PtdIns3P in the 4-position,
and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro,
but to a lesser extent.
- The last of these reactions occurs in vivo and is physiologically
relevant.
|
Cross-references |
BRENDA | 2.7.1.68 |
EC2PDB | 2.7.1.68 |
ExplorEnz | 2.7.1.68 |
PRIAM enzyme-specific profiles | 2.7.1.68 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.68 |
IUBMB Enzyme Nomenclature | 2.7.1.68 |
IntEnz | 2.7.1.68 |
MEDLINE | Find literature relating to 2.7.1.68 |
MetaCyc | 2.7.1.68 |
Rhea expert-curated reactions | 2.7.1.68 |
UniProtKB/Swiss-Prot |
O13853, ITS3_SCHPO; | P38994, MSS4_YEAST; | Q99755, PI51A_HUMAN; |
P70182, PI51A_MOUSE; | D3ZSI8, PI51A_RAT; | Q5ZJ58, PI51B_CHICK; |
O14986, PI51B_HUMAN; | P70181, PI51B_MOUSE; | Q5CZZ9, PI51B_RAT; |
O60331, PI51C_HUMAN; | O70161, PI51C_MOUSE; | Q5I6B8, PI51C_RAT; |
Q56YP2, PI5K1_ARATH; | Q6EX42, PI5K1_ORYSJ; | Q8L796, PI5K2_ARATH; |
O48709, PI5K3_ARATH; | Q9M1K2, PI5K4_ARATH; | Q9SLG9, PI5K5_ARATH; |
Q9SFB8, PI5K6_ARATH; | Q9SUI2, PI5K7_ARATH; | Q8RY89, PI5K8_ARATH; |
Q8L850, PI5K9_ARATH; | Q9LMN1, PI5KA_ARATH; | Q9M149, PI5KB_ARATH; |
Q17QS4, PI5L1_BOVIN; | Q5T9C9, PI5L1_HUMAN; |
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