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ENZYME entry: EC 2.7.1.68

Accepted Name
1-phosphatidylinositol-4-phosphate 5-kinase.
Alternative Name(s)
Diphosphoinositide kinase.
Phosphatidylinositol 4-phosphate kinase.
Phosphatidylinositol-4-phosphate 5-kinase.
PIP kinase.
PtdIns(4)P-5-kinase.
Type I PIP kinase.
Reaction catalysed
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Comment(s)
  • This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro, but to a lesser extent.
  • The last of these reactions occurs in vivo and is physiologically relevant.
Cross-references
BRENDA2.7.1.68
EC2PDB2.7.1.68
ExplorEnz2.7.1.68
PRIAM enzyme-specific profiles2.7.1.68
KEGG Ligand Database for Enzyme Nomenclature2.7.1.68
IUBMB Enzyme Nomenclature2.7.1.68
IntEnz2.7.1.68
MEDLINEFind literature relating to 2.7.1.68
MetaCyc2.7.1.68
UniProtKB/Swiss-Prot
O13853, ITS3_SCHPO;  P38994, MSS4_YEAST;  Q99755, PI51A_HUMAN;  
P70182, PI51A_MOUSE;  D3ZSI8, PI51A_RAT;  Q5ZJ58, PI51B_CHICK;  
O14986, PI51B_HUMAN;  P70181, PI51B_MOUSE;  Q5CZZ9, PI51B_RAT;  
O60331, PI51C_HUMAN;  O70161, PI51C_MOUSE;  Q5I6B8, PI51C_RAT;  
Q56YP2, PI5K1_ARATH;  Q6EX42, PI5K1_ORYSJ;  Q8L796, PI5K2_ARATH;  
O48709, PI5K3_ARATH;  Q9M1K2, PI5K4_ARATH;  Q9SLG9, PI5K5_ARATH;  
Q9SFB8, PI5K6_ARATH;  Q9SUI2, PI5K7_ARATH;  Q8RY89, PI5K8_ARATH;  
Q8L850, PI5K9_ARATH;  Q9LMN1, PI5KA_ARATH;  Q9M149, PI5KB_ARATH;  
Q17QS4, PI5L1_BOVIN;  Q5T9C9, PI5L1_HUMAN;  Q6U7H8, PI5L1_MOUSE;  

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