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ENZYME entry: EC 2.7.1.91

Accepted Name
Sphingosine kinase.
Alternative Name(s)
Dihydrosphingosine kinase.
Sphinganine kinase.
Sphingoid base kinase.
Reaction catalysed
ATP + a sphingoid base <=> ADP + a sphingoid base 1-phosphate
Comment(s)
  • The enzyme is involved in the production of sphingolipid metabolites.
  • It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine.
  • The exact substrate range depends on the species.
Cross-references
PROSITEPDOC50146
BRENDA2.7.1.91
EC2PDB2.7.1.91
ExplorEnz2.7.1.91
PRIAM enzyme-specific profiles2.7.1.91
KEGG Ligand Database for Enzyme Nomenclature2.7.1.91
IUBMB Enzyme Nomenclature2.7.1.91
IntEnz2.7.1.91
MEDLINEFind literature relating to 2.7.1.91
MetaCyc2.7.1.91
Rhea expert-curated reactions2.7.1.91
UniProtKB/Swiss-Prot
O14159, LCB4_SCHPO;  Q12246, LCB4_YEAST;  Q06147, LCB5_YEAST;  
Q8L7L1, SPHK1_ARATH;  Q18425, SPHK1_CAEEL;  Q9NYA1, SPHK1_HUMAN;  
Q8CI15, SPHK1_MOUSE;  Q91V26, SPHK1_RAT;  F2Y4A3, SPHK2_ARATH;  
Q9NRA0, SPHK2_HUMAN;  Q9JIA7, SPHK2_MOUSE;  Q86KF9, SPHKA_DICDI;  
Q6B516, SPHKB_DICDI;  

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