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ENZYME entry: EC 2.7.1.91
Accepted Name |
sphingosine kinase.
|
Alternative Name(s) |
dihydrosphingosine kinase. |
sphinganine kinase. |
sphingoid base kinase. |
Reaction catalysed |
a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+) |
Comment(s) |
- The enzyme is involved in the production of sphingolipid metabolites.
- It phosphorylates various sphingoid long-chain bases, such as
sphingosine, D-erythro-dihydrosphingosine (sphinganine),
phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine,
4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-
dihydrosphingosine.
- The exact substrate range depends on the species.
|
Cross-references |
BRENDA | 2.7.1.91 |
EC2PDB | 2.7.1.91 |
ExplorEnz | 2.7.1.91 |
PRIAM enzyme-specific profiles | 2.7.1.91 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.1.91 |
IUBMB Enzyme Nomenclature | 2.7.1.91 |
IntEnz | 2.7.1.91 |
MEDLINE | Find literature relating to 2.7.1.91 |
MetaCyc | 2.7.1.91 |
Rhea expert-curated reactions | 2.7.1.91 |
UniProtKB/Swiss-Prot |
O14159, LCB4_SCHPO; | Q12246, LCB4_YEAST; | Q06147, LCB5_YEAST; |
Q8L7L1, SPHK1_ARATH; | Q18425, SPHK1_CAEEL; | Q9NYA1, SPHK1_HUMAN; |
Q8CI15, SPHK1_MOUSE; | Q91V26, SPHK1_RAT; | F2Y4A3, SPHK2_ARATH; |
Q9NRA0, SPHK2_HUMAN; | Q9JIA7, SPHK2_MOUSE; | Q86KF9, SPHKA_DICDI; |
Q6B516, SPHKB_DICDI; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-