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ENZYME

ENZYME entry: EC 2.7.10.1

PURL: https://purl.expasy.org/enzyme/EC/2.7.10.1
Accepted Name
receptor protein-tyrosine kinase
Alternative Name(s)
receptor protein tyrosine kinase
Reaction catalysed
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)
Comment(s)
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
Cross-references
BRENDA2.7.10.1
EC2PDB2.7.10.1
ExplorEnz2.7.10.1
KEGG Ligand Database for Enzyme Nomenclature2.7.10.1
IUBMB Enzyme Nomenclature2.7.10.1
MEDLINEFind literature relating to 2.7.10.1
MetaCyc2.7.10.1
Rhea expert-curated reactions2.7.10.1
UniProtKB/Swiss-Prot
P13368, 7LESS_DROMEP20806, 7LESS_DROVIQ54N73, 7TMK1_DICDI
P0DV84, ALK_CANLFF8W3R9, ALK_DANREQ9UM73, ALK_HUMAN
P97793, ALK_MOUSEQ94F62, BAK1_ARATHO22476, BRI1_ARATH
Q9LJF3, BRL3_ARATHQ9VBW3, CAD96_DROMEG5EGK5, CAM1_CAEEL
Q9FGL5, CEPR1_ARATHQ9C7T7, CEPR2_ARATHP79750, CSF11_TAKRU
Q8UVR8, CSF12_TAKRUQ9I8N6, CSF1R_DANREP13369, CSF1R_FELCA
P07333, CSF1R_HUMANP09581, CSF1R_MOUSEQ00495, CSF1R_RAT
Q08345, DDR1_HUMANQ03146, DDR1_MOUSEQ7YR43, DDR1_PANTR
Q63474, DDR1_RATQ16832, DDR2_HUMANQ62371, DDR2_MOUSE
Q95ZV7, DDRB_CAEELP0CY46, EGFR_APIMEP13387, EGFR_CHICK
P04412, EGFR_DROMEP00533, EGFR_HUMANP55245, EGFR_MACMU
Q01279, EGFR_MOUSEQ10656, EGL15_CAEELO13148, EPA4A_DANRE
Q91845, EPA4A_XENLAQ91694, EPA4B_XENLAQ91571, EPB1A_XENLA
Q91736, EPB1B_XENLAO73875, EPB4A_DANREO73878, EPB4B_DANRE
P21709, EPHA1_HUMANQ60750, EPHA1_MOUSEP29317, EPHA2_HUMAN
Q1KL86, EPHA2_MACFAQ03145, EPHA2_MOUSEP29318, EPHA3_CHICK
O13146, EPHA3_DANREP29320, EPHA3_HUMANP29319, EPHA3_MOUSE
O08680, EPHA3_RATQ07496, EPHA4_CHICKP54764, EPHA4_HUMAN
Q03137, EPHA4_MOUSEP54755, EPHA5_CHICKP54756, EPHA5_HUMAN
Q60629, EPHA5_MOUSEP54757, EPHA5_RATQ9UF33, EPHA6_HUMAN
Q62413, EPHA6_MOUSEP54758, EPHA6_RATO42422, EPHA7_CHICK
Q15375, EPHA7_HUMANQ61772, EPHA7_MOUSEP54759, EPHA7_RAT
P29322, EPHA8_HUMANO09127, EPHA8_MOUSEP29321, EPHA8_RAT
Q5JZY3, EPHAA_HUMANQ8BYG9, EPHAA_MOUSEQ07494, EPHB1_CHICK
P54762, EPHB1_HUMANQ8CBF3, EPHB1_MOUSEP09759, EPHB1_RAT
P28693, EPHB2_CHICKQ90344, EPHB2_COTJAP29323, EPHB2_HUMAN
P54763, EPHB2_MOUSEQ07498, EPHB3_CHICKO13147, EPHB3_DANRE
P54753, EPHB3_HUMANP54754, EPHB3_MOUSEQ91735, EPHB3_XENLA
P54760, EPHB4_HUMANP54761, EPHB4_MOUSEQ07497, EPHB5_CHICK
O18735, ERBB2_CANLFP04626, ERBB2_HUMANQ60553, ERBB2_MESAU
P70424, ERBB2_MOUSEP06494, ERBB2_RATP21860, ERBB3_HUMAN
Q61526, ERBB3_MOUSEQ5RB22, ERBB3_PONABQ62799, ERBB3_RAT
Q15303, ERBB4_HUMANQ61527, ERBB4_MOUSEQ62956, ERBB4_RAT
P00534, ERBB_ALVP00535, ERBB_AVIERP11273, ERBB_AVIEU
P21804, FGFR1_CHICKQ07407, FGFR1_DROMEQ8MY86, FGFR1_DUGJA
P11362, FGFR1_HUMANP16092, FGFR1_MOUSEQ91285, FGFR1_PLEWA
Q04589, FGFR1_RATP22182, FGFR1_XENLAP18461, FGFR2_CHICK
Q8JG38, FGFR2_DANREQ09147, FGFR2_DROMEQ8MY85, FGFR2_DUGJA
P21802, FGFR2_HUMANP21803, FGFR2_MOUSEQ91147, FGFR2_NOTVI
Q91286, FGFR2_PLEWAQ03364, FGFR2_XENLAP18460, FGFR3_CHICK
Q9I8X3, FGFR3_DANREP22607, FGFR3_HUMANQ61851, FGFR3_MOUSE
Q91287, FGFR3_PLEWAO42127, FGFR3_XENLAQ90330, FGFR4_COTCO
Q90413, FGFR4_DANREP22455, FGFR4_HUMANQ03142, FGFR4_MOUSE
Q91288, FGFR4_PLEWAQ498D6, FGFR4_RATQ91743, FGFR4_XENLA
Q4H3K6, FGFR_CIOINQ95YM9, FGFR_HALROQ86PM4, FGFR_HYDVU
Q26614, FGFR_STRPUQ90Z00, FGR1A_DANREP36888, FLT3_HUMAN
Q00342, FLT3_MOUSEQ2MHE4, HT1_ARATHQ25197, HTK7_HYDVU
Q05688, IGF1R_BOVINP08069, IGF1R_HUMANQ60751, IGF1R_MOUSE
Q29000, IGF1R_PIGP24062, IGF1R_RATO73798, IGF1R_XENLA
O02466, ILPR_BRALAP14617, INSRR_CAVPOP14616, INSRR_HUMAN
Q9WTL4, INSRR_MOUSEQ64716, INSRR_RATQ93105, INSR_AEDAE
Q968Y9, INSR_CAEELP09208, INSR_DROMEP06213, INSR_HUMAN
Q28516, INSR_MACMUP15208, INSR_MOUSEP15127, INSR_RAT
Q9PVZ4, INSR_XENLAP00545, KFMS_FSVMDP34891, KIN15_CAEEL
P34892, KIN16_CAEELQ8JFR5, KITA_DANREP43481, KIT_BOVIN
Q76II0, KIT_CALJAO97799, KIT_CANLFQ28317, KIT_CAPHI
Q08156, KIT_CHICKQ28889, KIT_FELCAP04048, KIT_FSVHZ
P10721, KIT_HUMANP05532, KIT_MOUSEQ2HWD6, KIT_PIG
Q8AXC6, KIT_TAKRUQ91909, KIT_XENLAP24348, LET23_CAEEL
F1QVU0, LTK_DANREP29376, LTK_HUMANP08923, LTK_MOUSE
Q12866, MERTK_HUMANQ60805, MERTK_MOUSEP57097, MERTK_RAT
Q07DV8, MET_AOTNAQ00PJ8, MET_ATEABQ09YL1, MET_ATEGE
Q769I5, MET_BOVINQ2QLG5, MET_CALJAQ75ZY9, MET_CANLF
Q2IBA6, MET_CHLAEQ07DZ1, MET_COLGUQ07E48, MET_DASNO
A1X150, MET_ECHTEQ2IBG7, MET_EULMMA0M8S8, MET_FELCA
Q2IBF2, MET_GORGOQ2QLA9, MET_HORSEP08581, MET_HUMAN
Q108U6, MET_LOXAFQ2QL89, MET_MICMUP16056, MET_MOUSE
Q09YK0, MET_MUNMUQ07E24, MET_MUSPFQ07E37, MET_NEONE
Q07DY1, MET_NOMLEQ07E01, MET_ORNANQ2QLH6, MET_OTOGA
Q2QLF1, MET_PANTRA0M8R7, MET_PAPANQ2QLE0, MET_PIG
Q2QLC0, MET_PLEMOQ2IBD8, MET_PONABQ09YN5, MET_RABIT
P97523, MET_RATQ2IBC0, MET_RHIFEQ09YH7, MET_SAIBB
Q09YI9, MET_SHEEPQ25410, MIPR_LYMSTQ8AXY6, MUSK_CHICK
O15146, MUSK_HUMANQ61006, MUSK_MOUSEQ62838, MUSK_RAT
Q91009, NTRK1_CHICKP04629, NTRK1_HUMANQ3UFB7, NTRK1_MOUSE
P35739, NTRK1_RATQ91987, NTRK2_CHICKQ16620, NTRK2_HUMAN
P15209, NTRK2_MOUSEQ63604, NTRK2_RATQ91044, NTRK3_CHICK
Q16288, NTRK3_HUMANQ5IFJ9, NTRK3_MACFAQ6VNS1, NTRK3_MOUSE
Q5IS37, NTRK3_PANTRP24786, NTRK3_PIGQ03351, NTRK3_RAT
Q5IS82, NTRK3_SAIBBQ17833, OLD1_CAEELQ9PUF6, PGFRA_CHICK
Q9DE49, PGFRA_DANREP16234, PGFRA_HUMANP26618, PGFRA_MOUSE
P20786, PGFRA_RATQ8AXC7, PGFRA_TAKRUP26619, PGFRA_XENLA
Q6QNF3, PGFRB_CANLFP09619, PGFRB_HUMANP05622, PGFRB_MOUSE
Q05030, PGFRB_RATP79749, PGFRB_TAKRUQ40902, PRK1_PETIN
O22938, PXC3_ARATHP07949, RET_HUMANP35546, RET_MOUSE
G3V9H8, RET_RATQ9FN94, RLK0_ARATHP47735, RLK5_ARATH
Q9LIG2, RLK6_ARATHQ04912, RON_HUMANQ62190, RON_MOUSE
Q24488, ROR1_DROMEQ9V6K3, ROR2_DROMEQ01974, ROR2_HUMAN
Q9Z138, ROR2_MOUSEP08941, ROS1_CHICKP08922, ROS1_HUMAN
Q78DX7, ROS1_MOUSEQ63132, ROS1_RATP00529, ROS_AVISU
P42159, RTK2_GEOCYQ27324, RYK1_DROMEQ9V422, RYK2_DROME
P33497, RYK_AVIR3P34925, RYK_HUMANQ01887, RYK_MOUSE
Q9SKB2, SBIR1_ARATHO76411, SCD2_CAEELQ94AG2, SERK1_ARATH
Q9SKG5, SERK4_ARATHH2KZU7, SVH2_CAEELQ06805, TIE1_BOVIN
O73792, TIE1_DANREP35590, TIE1_HUMANQ06806, TIE1_MOUSE
Q06807, TIE2_BOVINO73791, TIE2_DANREQ02763, TIE2_HUMAN
Q02858, TIE2_MOUSED2IYS2, TORSO_BOMMOP18475, TORSO_DROME
O76997, TRK1_LYMSTQ98949, TYRO3_CHICKQ9YI66, TYRO3_DANRE
Q06418, TYRO3_HUMANP55144, TYRO3_MOUSEP55146, TYRO3_RAT
Q8QFP9, TYRO3_XENLAA0JM20, TYRO3_XENTRP30530, UFO_HUMAN
Q00993, UFO_MOUSEO61460, VAB1_CAEELQ21038, VER3_CAEEL
Q21041, VER4_CAEELQ8QHL3, VGFR1_CHICKP17948, VGFR1_HUMAN
P35969, VGFR1_MOUSEP53767, VGFR1_RATP52583, VGFR2_COTJA
Q5GIT4, VGFR2_DANREP35968, VGFR2_HUMANP35918, VGFR2_MOUSE
O08775, VGFR2_RATP79701, VGFR3_COTCOQ5MD89, VGFR3_DANRE
P35916, VGFR3_HUMANP35917, VGFR3_MOUSEQ91ZT1, VGFR3_RAT
Q8AXB3, VGFR4_DANREP13388, XMRK_XIPMAQ9C823, Y1523_ARATH
Q19238, YS3J_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.10.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-