ID 2.7.10.2 DE non-specific protein-tyrosine kinase. AN cytoplasmic protein tyrosine kinase. CA L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). CC -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a CC transmembrane domain. CC -!- In the human genome, 32 non-specific protein-tyrosine kinases have CC been identified and these can be divided into 10 families. CC -!- Formerly EC 2.7.1.112. DR P03949, ABL1_CAEEL ; P00519, ABL1_HUMAN ; P00520, ABL1_MOUSE ; DR P42684, ABL2_HUMAN ; Q4JIM5, ABL2_MOUSE ; P11681, ABL_CALVI ; DR P00522, ABL_DROME ; P10447, ABL_FSVHY ; P00521, ABL_MLVAB ; DR Q17R13, ACK1_BOVIN ; Q07912, ACK1_HUMAN ; O54967, ACK1_MOUSE ; DR Q5U2X5, ACK1_RAT ; Q9I7F7, ACKL_DROME ; Q9VZI2, ACK_DROME ; DR G5EBZ8, ARK1_CAEEL ; A2BIL7, BAZ1B_DANRE; Q9UIG0, BAZ1B_HUMAN; DR Q9Z277, BAZ1B_MOUSE; A8DZJ1, BAZ1B_XENLA; P51451, BLK_HUMAN ; DR P16277, BLK_MOUSE ; P51813, BMX_HUMAN ; P97504, BMX_MOUSE ; DR P08630, BTKL_DROME ; Q8JH64, BTK_CHICK ; Q06187, BTK_HUMAN ; DR P35991, BTK_MOUSE ; P39851, CAPB_STAAU ; Q3K0T0, CPSD_STRA1 ; DR Q04663, CPSD_STRA3 ; Q9AFI1, CPSD_STRA5 ; P0C0T9, CPSD_STRAG ; DR Q54520, CPSD_STREE ; Q9AHD2, CPSD_STRPN ; G5ECJ6, CSK1_CAEEL ; DR F4HVG8, CSK_ARATH ; Q0VBZ0, CSK_BOVIN ; P41239, CSK_CHICK ; DR P41240, CSK_HUMAN ; P41241, CSK_MOUSE ; P32577, CSK_RAT ; DR P19525, E2AK2_HUMAN; Q03963, E2AK2_MOUSE; Q63184, E2AK2_RAT ; DR A5D791, E2AK3_BOVIN; Q9NZJ5, E2AK3_HUMAN; Q9Z2B5, E2AK3_MOUSE; DR Q9Z1Z1, E2AK3_RAT ; Q00944, FAK1_CHICK ; Q05397, FAK1_HUMAN ; DR P34152, FAK1_MOUSE ; O35346, FAK1_RAT ; Q91738, FAK1_XENLA ; DR Q14289, FAK2_HUMAN ; Q9QVP9, FAK2_MOUSE ; P70600, FAK2_RAT ; DR Q9TTY2, FER_CANLF ; P18106, FER_DROME ; P16591, FER_HUMAN ; DR P70451, FER_MOUSE ; P09760, FER_RAT ; P14238, FES_FELCA ; DR P00542, FES_FSVGA ; P00543, FES_FSVST ; P07332, FES_HUMAN ; DR P16879, FES_MOUSE ; P00544, FGR_FSVGR ; P09769, FGR_HUMAN ; DR P14234, FGR_MOUSE ; Q6P6U0, FGR_RAT ; P00541, FPS_AVISP ; DR P00530, FPS_FUJSV ; Q22146, FRK1_CAEEL ; P42685, FRK_HUMAN ; DR Q922K9, FRK_MOUSE ; Q62662, FRK_RAT ; Q6EWH2, FYNA_DANRE ; DR F1RDG9, FYNB_DANRE ; A0JNB0, FYN_BOVIN ; Q05876, FYN_CHICK ; DR P06241, FYN_HUMAN ; P39688, FYN_MOUSE ; A1Y2K1, FYN_PIG ; DR Q62844, FYN_RAT ; P13406, FYN_XENLA ; P27446, FYN_XIPHE ; DR P08631, HCK_HUMAN ; Q95M30, HCK_MACFA ; P08103, HCK_MOUSE ; DR P50545, HCK_RAT ; P53356, HTK16_HYDVU; Q08881, ITK_HUMAN ; DR Q03526, ITK_MOUSE ; Q09178, JAK1_CYPCA ; O12990, JAK1_DANRE ; DR P23458, JAK1_HUMAN ; P52332, JAK1_MOUSE ; Q75R65, JAK2_CHICK ; DR O60674, JAK2_HUMAN ; Q62120, JAK2_MOUSE ; O19064, JAK2_PIG ; DR Q5RB23, JAK2_PONAB ; Q62689, JAK2_RAT ; P52333, JAK3_HUMAN ; DR Q62137, JAK3_MOUSE ; Q63272, JAK3_RAT ; Q24592, JAK_DROME ; DR Q5PU49, KPCD_CANLF ; Q05655, KPCD_HUMAN ; P28867, KPCD_MOUSE ; DR P11979, KPYM_FELCA ; P14618, KPYM_HUMAN ; P52480, KPYM_MOUSE ; DR P11974, KPYM_RABIT ; P11980, KPYM_RAT ; F1N9Y5, KSYK_CHICK ; DR P43405, KSYK_HUMAN ; P48025, KSYK_MOUSE ; Q00655, KSYK_PIG ; DR Q64725, KSYK_RAT ; Q5PXS1, LCK_AOTNA ; P42683, LCK_CHICK ; DR P06239, LCK_HUMAN ; P06240, LCK_MOUSE ; Q01621, LCK_RAT ; DR Q95KR7, LCK_SAISC ; P07948, LYN_HUMAN ; P25911, LYN_MOUSE ; DR Q07014, LYN_RAT ; Q1DB00, MASK_MYXXD ; P42679, MATK_HUMAN ; DR P41242, MATK_MOUSE ; P41243, MATK_RAT ; Q14680, MELK_HUMAN ; DR Q61846, MELK_MOUSE ; P42345, MTOR_HUMAN ; Q9JLN9, MTOR_MOUSE ; DR P42346, MTOR_RAT ; Q504Y2, PKDCC_HUMAN; Q5RJI4, PKDCC_MOUSE; DR Q13882, PTK6_HUMAN ; Q64434, PTK6_MOUSE ; Q3SZJ2, RIPK2_BOVIN; DR O43353, RIPK2_HUMAN; P58801, RIPK2_MOUSE; P23049, SEA_AVIET ; DR Q24145, SHARK_DROME; Q10925, SID3_CAEEL ; A8WZ92, SPE8_CAEBR ; DR O01798, SPE8_CAEEL ; P42687, SPK1_GIRTI ; P18160, SPLA_DICDI ; DR P18161, SPLB_DICDI ; G5EE56, SRC1_CAEEL ; P13115, SRC1_XENLA ; DR O45539, SRC2_CAEEL ; P13116, SRC2_XENLA ; Q9V9J3, SRC42_DROME; DR P00528, SRC64_DROME; P15054, SRC_AVIS2 ; P00525, SRC_AVISR ; DR P14084, SRC_AVISS ; P14085, SRC_AVIST ; P00523, SRC_CHICK ; DR Q1JPZ3, SRC_DANRE ; P12931, SRC_HUMAN ; P05480, SRC_MOUSE ; DR Q9WUD9, SRC_RAT ; P25020, SRC_RSVH1 ; P00526, SRC_RSVP ; DR P31693, SRC_RSVPA ; P00524, SRC_RSVSA ; P63185, SRC_RSVSE ; DR P42686, SRK1_SPOLA ; P42688, SRK2_SPOLA ; P42689, SRK3_SPOLA ; DR P42690, SRK4_SPOLA ; Q9H3Y6, SRMS_HUMAN ; Q62270, SRMS_MOUSE ; DR O75716, STK16_HUMAN; O88697, STK16_MOUSE; P57760, STK16_RAT ; DR P17713, STK_HYDVU ; Q6J9G0, STYK1_HUMAN; Q6J9G1, STYK1_MOUSE; DR P42680, TEC_HUMAN ; P24604, TEC_MOUSE ; Q13470, TNK1_HUMAN ; DR Q99ML2, TNK1_MOUSE ; P42681, TXK_HUMAN ; P42682, TXK_MOUSE ; DR P29597, TYK2_HUMAN ; Q9R117, TYK2_MOUSE ; O36385, VG36_ALHV1 ; DR Q9HUF7, WAAP_PSEAE ; Q8AYK6, WEE1A_XENLA; Q8QGV2, WEE1B_XENLA; DR Q8L4H0, WEE1_ARATH ; P54350, WEE1_DROME ; P30291, WEE1_HUMAN ; DR P47810, WEE1_MOUSE ; Q6Z829, WEE1_ORYSJ ; Q63802, WEE1_RAT ; DR P07527, WEE1_SCHPO ; P47817, WEE2A_XENLA; O57473, WEE2B_XENLA; DR Q6DFE0, WEE2C_XENLA; D2HHP1, WEE2_AILME ; E2RSS3, WEE2_CANLF ; DR E1BTE1, WEE2_CHICK ; Q1LX51, WEE2_DANRE ; P0C1S8, WEE2_HUMAN ; DR Q66JT0, WEE2_MOUSE ; A4PES0, WEE2_PIG ; A4QNA8, WEE2_XENTR ; DR Q9LSC2, Y3589_ARATH; P00527, YES_AVISY ; Q28923, YES_CANLF ; DR P09324, YES_CHICK ; A1A5H8, YES_DANRE ; P07947, YES_HUMAN ; DR Q04736, YES_MOUSE ; F1LM93, YES_RAT ; P10936, YES_XENLA ; DR P27447, YES_XIPHE ; Q02977, YRK_CHICK ; Q54G28, YTYK1_DICDI; DR Q54R58, YTYK2_DICDI; P71051, YVEL_BACSU ; P96716, YWQD_BACSU ; DR Q11112, YX05_CAEEL ; P43403, ZAP70_HUMAN; P43404, ZAP70_MOUSE; //