Expasy logo


ENZYME entry: EC

Accepted Name
bacterial tyrosine kinase
Alternative Name(s)
bacterial protein tyrosine kinase
Reaction catalysed
ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]
  • This family of enzymes includes most of the bacterial tyrosine kinases.
  • These enzymes do not share sequence or structural homology with eukaryotic tyrosine kinases, and exploit ATP/GTP-binding Walker motifs to catalyze autophosphorylation and substrate phosphorylation on tyrosine.
  • Two subfamilies have been defined: P-type enzymes contain an N-terminal transmembrane portion and an extracellular hairpin loop domain. The intracellular portion comprises the catalytic domain and a tyrosine-rich C-terminal domain that contains the site for autophosphorylation.
  • In F-type enzymes the extracellular transmembrane domain and the intracellular catalytic domain are two independent proteins encoded by two separate genes.
  • The majority of characterized bacterial tyrosine kinases regulate the production and export of capsular and extracellular polysaccharides, but other members are involved in many other functions.
PRIAM enzyme-specific profiles2.7.10.3
KEGG Ligand Database for Enzyme Nomenclature2.7.10.3
IUBMB Enzyme Nomenclature2.7.10.3
MEDLINEFind literature relating to
Rhea expert-curated reactions2.7.10.3

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.10.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-