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ENZYME entry: EC 2.7.11.10

Accepted Name
I-kappa-B kinase.
Alternative Name(s)
CHUK.
IKBKA.
IKBKB.
IKK.
IKK-1.
IKK-2.
Inhibitor of NF-kappa-B kinase.
TANK-binding kinase 1.
TBK1.
Reaction catalysed
ATP + [I-kappa-B protein] <=> ADP + [I-kappa-B phosphoprotein]
Comment(s)
  • Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway.
  • Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis.
  • If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.10
EC2PDB2.7.11.10
ExplorEnz2.7.11.10
PRIAM enzyme-specific profiles2.7.11.10
KEGG Ligand Database for Enzyme Nomenclature2.7.11.10
IUBMB Enzyme Nomenclature2.7.11.10
IntEnz2.7.11.10
MEDLINEFind literature relating to 2.7.11.10
MetaCyc2.7.11.10
Rhea expert-curated reactions2.7.11.10
UniProtKB/Swiss-Prot
Q95KV1, IKKA_BOVIN;  Q5ZJB4, IKKA_CHICK;  Q4G3H4, IKKA_DANRE;  
O15111, IKKA_HUMAN;  Q60680, IKKA_MOUSE;  Q6GM53, IKKA_XENLA;  
Q28DZ1, IKKA_XENTR;  Q95KV0, IKKB_BOVIN;  Q9VEZ5, IKKB_DROME;  
O14920, IKKB_HUMAN;  O88351, IKKB_MOUSE;  Q9QY78, IKKB_RAT;  
Q14164, IKKE_HUMAN;  Q9R0T8, IKKE_MOUSE;  

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