ENZYME entry: EC 2.7.11.10
Accepted Name |
IkappaB kinase.
|
Alternative Name(s) |
CHUK. |
IKBKA. |
IKBKB. |
IKK. |
IKK-1. |
IKK-2. |
inhibitor of NFkappaB kinase. |
TANK-binding kinase 1. |
TBK1. |
Reaction catalysed |
ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein] |
Comment(s) |
- Phosphorylates IkappaB proteins at specific serine residues, which
marks them for destruction via the ubiquitination pathway.
- Subsequent degradation of the IkappaB complex (IKK) activates
NF-kappaB, a translation factor that plays an important role in
inflammation, immunity, cell proliferation and apoptosis.
- If the serine residues are replaced by threonine residues,
the activity of the enzyme is decreased considerably.
- Formerly EC 2.7.1.37.
|
Cross-references |
BRENDA | 2.7.11.10 |
EC2PDB | 2.7.11.10 |
ExplorEnz | 2.7.11.10 |
PRIAM enzyme-specific profiles | 2.7.11.10 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.10 |
IUBMB Enzyme Nomenclature | 2.7.11.10 |
IntEnz | 2.7.11.10 |
MEDLINE | Find literature relating to 2.7.11.10 |
MetaCyc | 2.7.11.10 |
Rhea expert-curated reactions | 2.7.11.10 |
UniProtKB/Swiss-Prot |
Q95KV1, IKKA_BOVIN; | Q5ZJB4, IKKA_CHICK; | Q4G3H4, IKKA_DANRE; |
O15111, IKKA_HUMAN; | Q60680, IKKA_MOUSE; | Q6GM53, IKKA_XENLA; |
Q28DZ1, IKKA_XENTR; | Q95KV0, IKKB_BOVIN; | Q9VEZ5, IKKB_DROME; |
O14920, IKKB_HUMAN; | O88351, IKKB_MOUSE; | Q9QY78, IKKB_RAT; |
Q14164, IKKE_HUMAN; | Q9R0T8, IKKE_MOUSE; |
|
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