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ENZYME

ENZYME entry: EC 2.7.11.10

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.10
Accepted Name
IkappaB kinase
Alternative Name(s)
CHUK
IKBKA
IKBKB
IKK
IKK-1
IKK-2
inhibitor of NFkappaB kinase
TANK-binding kinase 1
TBK1
Reaction catalysed
L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)
Comment(s)
  • Phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway.
  • Subsequent degradation of the IkappaB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis.
  • If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.10
EC2PDB2.7.11.10
ExplorEnz2.7.11.10
KEGG Ligand Database for Enzyme Nomenclature2.7.11.10
IUBMB Enzyme Nomenclature2.7.11.10
MEDLINEFind literature relating to 2.7.11.10
MetaCyc2.7.11.10
Rhea expert-curated reactions2.7.11.10
UniProtKB/Swiss-Prot
Q95KV1, IKKA_BOVINQ5ZJB4, IKKA_CHICKQ4G3H4, IKKA_DANRE
O15111, IKKA_HUMANQ60680, IKKA_MOUSEQ6GM53, IKKA_XENLA
Q28DZ1, IKKA_XENTRQ95KV0, IKKB_BOVINQ9VEZ5, IKKB_DROME
O14920, IKKB_HUMANO88351, IKKB_MOUSEQ9QY78, IKKB_RAT
Q14164, IKKE_HUMANQ9R0T8, IKKE_MOUSE

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