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ENZYME

ENZYME entry: EC 2.7.11.13

Accepted Name
protein kinase C
Alternative Name(s)
calcium/phospholipid dependent protein kinase
calcium-dependent protein kinase C
calcium-independent protein kinase C
cPKC
nPKC
PKC
Reaction catalysed
  • ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
  • ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Comment(s)
  • A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
  • They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
  • Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
  • Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.13
EC2PDB2.7.11.13
ExplorEnz2.7.11.13
PRIAM enzyme-specific profiles2.7.11.13
KEGG Ligand Database for Enzyme Nomenclature2.7.11.13
IUBMB Enzyme Nomenclature2.7.11.13
IntEnz2.7.11.13
MEDLINEFind literature relating to 2.7.11.13
MetaCyc2.7.11.13
Rhea expert-curated reactions2.7.11.13
UniProtKB/Swiss-Prot
A1Z9X0, APKC_DROMEA8XWC4, DKF1_CAEBRQ9XUJ7, DKF1_CAEEL
A8XQD5, DKF2_CAEBRO45818, DKF2_CAEELP34885, KPC1B_CAEEL
Q16974, KPC1_APLCAQ00078, KPC1_ASPNGP34722, KPC1_CAEEL
P43057, KPC1_CANAXO42632, KPC1_COCHEP05130, KPC1_DROME
Q99014, KPC1_HYPJEQ25378, KPC1_LYTPIP87253, KPC1_NEUCR
P24583, KPC1_YEASTQ16975, KPC2_APLCAP90980, KPC2_CAEEL
P13677, KPC2_DROMEA8WUG4, KPC3_CAEBRQ19266, KPC3_CAEEL
P13678, KPC3_DROMEP83099, KPC4_DROMEP04409, KPCA_BOVIN
P17252, KPCA_HUMANP20444, KPCA_MOUSEP10102, KPCA_RABIT
P05696, KPCA_RATP05126, KPCB_BOVINQ7SY24, KPCB_DANRE
P05771, KPCB_HUMANP68404, KPCB_MOUSEP05772, KPCB_RABIT
P68403, KPCB_RATQ7LZQ8, KPCB_XENLAA8KBH6, KPCB_XENTR
Q15139, KPCD1_HUMANQ62101, KPCD1_MOUSEQ9WTQ1, KPCD1_RAT
Q9BZL6, KPCD2_HUMANQ8BZ03, KPCD2_MOUSEQ5XIS9, KPCD2_RAT
O94806, KPCD3_HUMANQ8K1Y2, KPCD3_MOUSEQ5PU49, KPCD_CANLF
Q05655, KPCD_HUMANP28867, KPCD_MOUSEP09215, KPCD_RAT
Q02156, KPCE_HUMANP16054, KPCE_MOUSEP10830, KPCE_RABIT
P09216, KPCE_RATP05128, KPCG_BOVINP05129, KPCG_HUMAN
Q4R4U2, KPCG_MACFAP63318, KPCG_MOUSEP10829, KPCG_RABIT
P63319, KPCG_RATQ90XF2, KPCI_DANREP41743, KPCI_HUMAN
Q62074, KPCI_MOUSEQ5R4K9, KPCI_PONABF1M7Y5, KPCI_RAT
P24723, KPCL_HUMANP23298, KPCL_MOUSEQ64617, KPCL_RAT
Q04759, KPCT_HUMANQ02111, KPCT_MOUSEQ9WTQ0, KPCT_RAT
Q05513, KPCZ_HUMANQ02956, KPCZ_MOUSEO19111, KPCZ_RABIT
P09217, KPCZ_RATP36582, PCK1_SCHPOP36583, PCK2_SCHPO
Q4WVG0, PKCA_ASPFUA1A4I4, PKN1_BOVINQ16512, PKN1_HUMAN
P70268, PKN1_MOUSEQ63433, PKN1_RATA7MBL8, PKN2_DANRE
Q16513, PKN2_HUMANQ8BWW9, PKN2_MOUSEO08874, PKN2_RAT
Q6P5Z2, PKN3_HUMANQ8K045, PKN3_MOUSEA1Z7T0, PKN_DROME

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