ENZYME entry: EC 2.7.11.13

Accepted Name

protein kinase C

Alternative Name(s)

calcium/phospholipid dependent protein kinase

calcium-dependent protein kinase C

calcium-independent protein kinase C

cPKC

nPKC

PKC

Reaction catalysed

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Comment(s)

A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
Formerly EC 2.7.1.37.

Cross-references

BRENDA

2.7.11.13

EC2PDB

2.7.11.13

ExplorEnz

2.7.11.13

PRIAM enzyme-specific profiles

2.7.11.13

KEGG Ligand Database for Enzyme Nomenclature

2.7.11.13

IUBMB Enzyme Nomenclature

2.7.11.13

IntEnz

2.7.11.13

MEDLINE

Find literature relating to 2.7.11.13

MetaCyc

2.7.11.13

Rhea expert-curated reactions

2.7.11.13

UniProtKB/Swiss-Prot

A1Z9X0, APKC_DROME	A8XWC4, DKF1_CAEBR	Q9XUJ7, DKF1_CAEEL
A8XQD5, DKF2_CAEBR	O45818, DKF2_CAEEL	P34885, KPC1B_CAEEL
Q16974, KPC1_APLCA	Q00078, KPC1_ASPNG	P34722, KPC1_CAEEL
P43057, KPC1_CANAX	O42632, KPC1_COCHE	P05130, KPC1_DROME
Q99014, KPC1_HYPJE	Q25378, KPC1_LYTPI	P87253, KPC1_NEUCR
P24583, KPC1_YEAST	Q16975, KPC2_APLCA	P90980, KPC2_CAEEL
P13677, KPC2_DROME	A8WUG4, KPC3_CAEBR	Q19266, KPC3_CAEEL
P13678, KPC3_DROME	P83099, KPC4_DROME	P04409, KPCA_BOVIN
P17252, KPCA_HUMAN	P20444, KPCA_MOUSE	P10102, KPCA_RABIT
P05696, KPCA_RAT	P05126, KPCB_BOVIN	Q7SY24, KPCB_DANRE
P05771, KPCB_HUMAN	P68404, KPCB_MOUSE	P05772, KPCB_RABIT
P68403, KPCB_RAT	Q7LZQ8, KPCB_XENLA	A8KBH6, KPCB_XENTR
Q15139, KPCD1_HUMAN	Q62101, KPCD1_MOUSE	Q9WTQ1, KPCD1_RAT
Q9BZL6, KPCD2_HUMAN	Q8BZ03, KPCD2_MOUSE	Q5XIS9, KPCD2_RAT
O94806, KPCD3_HUMAN	Q8K1Y2, KPCD3_MOUSE	Q5PU49, KPCD_CANLF
Q05655, KPCD_HUMAN	P28867, KPCD_MOUSE	P09215, KPCD_RAT
Q02156, KPCE_HUMAN	P16054, KPCE_MOUSE	P10830, KPCE_RABIT
P09216, KPCE_RAT	P05128, KPCG_BOVIN	P05129, KPCG_HUMAN
Q4R4U2, KPCG_MACFA	P63318, KPCG_MOUSE	P10829, KPCG_RABIT
P63319, KPCG_RAT	Q90XF2, KPCI_DANRE	P41743, KPCI_HUMAN
Q62074, KPCI_MOUSE	Q5R4K9, KPCI_PONAB	F1M7Y5, KPCI_RAT
P24723, KPCL_HUMAN	P23298, KPCL_MOUSE	Q64617, KPCL_RAT
Q04759, KPCT_HUMAN	Q02111, KPCT_MOUSE	Q9WTQ0, KPCT_RAT
Q05513, KPCZ_HUMAN	Q02956, KPCZ_MOUSE	O19111, KPCZ_RABIT
P09217, KPCZ_RAT	P36582, PCK1_SCHPO	P36583, PCK2_SCHPO
Q4WVG0, PKCA_ASPFU	A1A4I4, PKN1_BOVIN	Q16512, PKN1_HUMAN
P70268, PKN1_MOUSE	Q63433, PKN1_RAT	A7MBL8, PKN2_DANRE
Q16513, PKN2_HUMAN	Q8BWW9, PKN2_MOUSE	O08874, PKN2_RAT
Q6P5Z2, PKN3_HUMAN	Q8K045, PKN3_MOUSE	A1Z7T0, PKN_DROME

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