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ENZYME

ENZYME entry: EC 2.7.11.18

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.18
Accepted Name
[myosin light-chain] kinase
Alternative Name(s)
[myosin-light-chain] kinase
calcium/calmodulin-dependent myosin light chain kinase
MLCK
MLCkase
myosin kinase
myosin light chain kinase
myosin light-chain kinase
myosin light-chain kinase (phosphorylating)
myosin light chain protein kinase
smooth-muscle-myosin-light-chain kinase
Reaction catalysed
  • L-seryl-[myosin light chain] + ATP = O-phospho-L-seryl-[myosin light chain] + ADP + H(+)
  • L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H(+)
Comment(s)
  • Requires calmodulin for activity.
  • The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly.
  • Formerly EC 2.7.1.117.
Cross-references
BRENDA2.7.11.18
EC2PDB2.7.11.18
ExplorEnz2.7.11.18
KEGG Ligand Database for Enzyme Nomenclature2.7.11.18
IUBMB Enzyme Nomenclature2.7.11.18
MEDLINEFind literature relating to 2.7.11.18
MetaCyc2.7.11.18
Rhea expert-curated reactions2.7.11.18
UniProtKB/Swiss-Prot
A4IFM7, MYLK2_BOVINQ9H1R3, MYLK2_HUMANQ8VCR8, MYLK2_MOUSE
P07313, MYLK2_RABITP20689, MYLK2_RATA8C984, MYLK3_DANRE
Q32MK0, MYLK3_HUMANQ3UIZ8, MYLK3_MOUSEQ5RDG7, MYLK3_PONAB
E9PT87, MYLK3_RATP25323, MYLKA_DICDIQ86AD7, MYLKB_DICDI
Q54SJ5, MYLKC_DICDIQ54CY9, MYLKD_DICDIQ54PB4, MYLKE_DICDI
Q54W86, MYLKF_DICDIQ869W6, MYLKG_DICDIQ28824, MYLK_BOVIN
P11799, MYLK_CHICKQ15746, MYLK_HUMANQ6PDN3, MYLK_MOUSE
P79280, MYLK_PIGP29294, MYLK_RABITO02827, MYLK_SHEEP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-