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ENZYME entry: EC 2.7.11.18

Accepted Name
[myosin light-chain] kinase.
Alternative Name(s)
[myosin-light-chain] kinase.
calcium/calmodulin-dependent myosin light chain kinase.
MLCK.
MLCkase.
myosin kinase.
myosin light chain kinase.
myosin light-chain kinase.
myosin light-chain kinase (phosphorylating).
myosin light chain protein kinase.
smooth-muscle-myosin-light-chain kinase.
Reaction catalysed
  • ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]
  • ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]
Comment(s)
  • Requires calmodulin for activity.
  • The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly.
  • Formerly EC 2.7.1.117.
Cross-references
BRENDA2.7.11.18
EC2PDB2.7.11.18
ExplorEnz2.7.11.18
PRIAM enzyme-specific profiles2.7.11.18
KEGG Ligand Database for Enzyme Nomenclature2.7.11.18
IUBMB Enzyme Nomenclature2.7.11.18
IntEnz2.7.11.18
MEDLINEFind literature relating to 2.7.11.18
MetaCyc2.7.11.18
Rhea expert-curated reactions2.7.11.18
UniProtKB/Swiss-Prot
A4IFM7, MYLK2_BOVIN;  Q9H1R3, MYLK2_HUMAN;  Q8VCR8, MYLK2_MOUSE;  
P07313, MYLK2_RABIT;  P20689, MYLK2_RAT;  A8C984, MYLK3_DANRE;  
Q32MK0, MYLK3_HUMAN;  Q3UIZ8, MYLK3_MOUSE;  Q5RDG7, MYLK3_PONAB;  
E9PT87, MYLK3_RAT;  P25323, MYLKA_DICDI;  Q86AD7, MYLKB_DICDI;  
Q54SJ5, MYLKC_DICDI;  Q54CY9, MYLKD_DICDI;  Q54PB4, MYLKE_DICDI;  
Q54W86, MYLKF_DICDI;  Q869W6, MYLKG_DICDI;  Q28824, MYLK_BOVIN;  
P11799, MYLK_CHICK;  Q15746, MYLK_HUMAN;  Q6PDN3, MYLK_MOUSE;  
P79280, MYLK_PIG;  P29294, MYLK_RABIT;  O02827, MYLK_SHEEP;  

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