| Accepted Name |
|---|
| [myosin light-chain] kinase.
|
| Alternative Name(s) |
|---|
| [myosin-light-chain] kinase. |
| calcium/calmodulin-dependent myosin light chain kinase. |
| MLCK. |
| MLCkase. |
| myosin kinase. |
| myosin light chain kinase. |
| myosin light-chain kinase. |
| myosin light-chain kinase (phosphorylating). |
| myosin light chain protein kinase. |
| smooth-muscle-myosin-light-chain kinase. |
| Reaction catalysed |
|---|
- ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]
- ATP + L-threonyl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]
|
| Comment(s) |
|---|
- Requires calmodulin for activity.
- The 20 kDa light chain from smooth muscle myosin is phosphorylated
more rapidly than any other acceptor, but light chains from other
myosins and myosin itself can act as acceptors, more slowly.
- Formerly EC 2.7.1.117.
|
| Cross-references |
|---|
| BRENDA | 2.7.11.18 |
| EC2PDB | 2.7.11.18 |
| ExplorEnz | 2.7.11.18 |
| PRIAM enzyme-specific profiles | 2.7.11.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.18 |
| IUBMB Enzyme Nomenclature | 2.7.11.18 |
| IntEnz | 2.7.11.18 |
| MEDLINE | Find literature relating to 2.7.11.18 |
| MetaCyc | 2.7.11.18 |
| Rhea expert-curated reactions | 2.7.11.18 |
| UniProtKB/Swiss-Prot |
| A4IFM7, MYLK2_BOVIN; | Q9H1R3, MYLK2_HUMAN; | Q8VCR8, MYLK2_MOUSE; |
| P07313, MYLK2_RABIT; | P20689, MYLK2_RAT; | A8C984, MYLK3_DANRE; |
| Q32MK0, MYLK3_HUMAN; | Q3UIZ8, MYLK3_MOUSE; | Q5RDG7, MYLK3_PONAB; |
| E9PT87, MYLK3_RAT; | P25323, MYLKA_DICDI; | Q86AD7, MYLKB_DICDI; |
| Q54SJ5, MYLKC_DICDI; | Q54CY9, MYLKD_DICDI; | Q54PB4, MYLKE_DICDI; |
| Q54W86, MYLKF_DICDI; | Q869W6, MYLKG_DICDI; | Q28824, MYLK_BOVIN; |
| P11799, MYLK_CHICK; | Q15746, MYLK_HUMAN; | Q6PDN3, MYLK_MOUSE; |
| P79280, MYLK_PIG; | P29294, MYLK_RABIT; | O02827, MYLK_SHEEP; |
|