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ENZYME

ENZYME entry: EC 2.7.11.19

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.19
Accepted Name
phosphorylase kinase
Alternative Name(s)
dephosphophosphorylase kinase
glycogen phosphorylase kinase
PHK
phosphorylase b kinase
phosphorylase B kinase
phosphorylase kinase (phosphorylating)
Reaction catalysed
2 ATP + phosphorylase b = 2 ADP + phosphorylase a
Comment(s)
  • Requires calmodulin for activity.
  • The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b.
  • For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase.
  • The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b.
  • The gamma subunit of the tetrameric alphabetagammadelta enzyme is the catalytic subunit.
  • Formerly EC 2.7.1.38.
Cross-references
BRENDA2.7.11.19
EC2PDB2.7.11.19
ExplorEnz2.7.11.19
KEGG Ligand Database for Enzyme Nomenclature2.7.11.19
IUBMB Enzyme Nomenclature2.7.11.19
MEDLINEFind literature relating to 2.7.11.19
MetaCyc2.7.11.19
Rhea expert-curated reactions2.7.11.19
UniProtKB/Swiss-Prot
Q16816, PHKG1_HUMANP07934, PHKG1_MOUSEP00518, PHKG1_RABIT
P13286, PHKG1_RATQ2KJ16, PHKG2_BOVINP15735, PHKG2_HUMAN
Q9DB30, PHKG2_MOUSEP31325, PHKG2_RAT

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