ID 2.7.11.22 DE cyclin-dependent kinase. AN cdc2 kinase. AN cdk-activating kinase. AN Cdk-activating protein kinase. CA (1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]. CA (2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- CA [protein]. CC -!- Activation of cyclin-dependent kinases requires association of the CC enzyme with a regulatory subunit referred to as a cyclin. CC -!- It is the sequential activation and inactivation of cyclin-dependent CC kinases, through the periodic synthesis and destruction of cyclins, CC that provides the primary means of cell-cycle regulation. CC -!- Formerly EC 2.7.1.37. DR Q4WTN5, BUR1_ASPFU ; Q9Y7W4, BUR1_CANAL ; Q6FQ83, BUR1_CANGA ; DR Q6BV06, BUR1_DEBHA ; Q96VK3, BUR1_EMENI ; Q75D46, BUR1_EREGS ; DR Q4I5U9, BUR1_GIBZE ; Q6CRA9, BUR1_KLULA ; Q871M9, BUR1_NEUCR ; DR Q6C842, BUR1_YARLI ; P23293, BUR1_YEAST ; P43568, CAK1_YEAST ; DR P38973, CC2H1_TRYBB; P54664, CC2H1_TRYCO; P54665, CC2H2_TRYBB; DR P54666, CC2H3_TRYBB; Q09437, CD111_CAEEL; Q23357, CD112_CAEEL; DR Q9UQ88, CD11A_HUMAN; P21127, CD11B_HUMAN; P24788, CD11B_MOUSE; DR P46892, CD11B_RAT ; P24923, CDC21_MEDSA; P19026, CDC21_PEA ; DR Q05006, CDC22_MEDSA; P28567, CDC22_PEA ; Q38772, CDC2A_ANTMA; DR Q38773, CDC2B_ANTMA; Q38774, CDC2C_ANTMA; Q38775, CDC2D_ANTMA; DR P23111, CDC2_MAIZE ; P93101, CDC2_OXYRB ; P43290, CDC2_PETHY ; DR Q41639, CDC2_VIGAC ; P52389, CDC2_VIGUN ; Q2TBL8, CDK10_BOVIN; DR Q55GS4, CDK10_DICDI; Q15131, CDK10_HUMAN; Q3UMM4, CDK10_MOUSE; DR Q4KM47, CDK10_RAT ; Q54RB2, CDK11_DICDI; D2H526, CDK12_AILME; DR E1BB50, CDK12_BOVIN; P46551, CDK12_CAEEL; Q9VP22, CDK12_DROME; DR Q9NYV4, CDK12_HUMAN; Q14AX6, CDK12_MOUSE; Q3MJK5, CDK12_RAT ; DR B5DE93, CDK12_XENTR; E1BB52, CDK13_BOVIN; Q14004, CDK13_HUMAN; DR Q69ZA1, CDK13_MOUSE; B0VXE8, CDK14_CALJA; C0RW22, CDK14_DASNO; DR O94921, CDK14_HUMAN; O35495, CDK14_MOUSE; B0VXL7, CDK14_PLEMO; DR B6A7Q3, CDK14_RABIT; Q6DJM7, CDK14_XENLA; A4IIW7, CDK14_XENTR; DR Q1RLU9, CDK15_DANRE; Q96Q40, CDK15_HUMAN; Q3V3A1, CDK15_MOUSE; DR Q00536, CDK16_HUMAN; Q04735, CDK16_MOUSE; Q63686, CDK16_RAT ; DR Q8I7M8, CDK17_CAEEL; Q00537, CDK17_HUMAN; Q8K0D0, CDK17_MOUSE; DR O35831, CDK17_RAT ; Q07002, CDK18_HUMAN; Q04899, CDK18_MOUSE; DR Q5RD01, CDK18_PONAB; O35832, CDK18_RAT ; Q9BWU1, CDK19_HUMAN; DR Q8BWD8, CDK19_MOUSE; P35567, CDK1A_XENLA; P24033, CDK1B_XENLA; DR P54119, CDK1_AJECA ; P48734, CDK1_BOVIN ; A8XA58, CDK1_CAEBR ; DR P34556, CDK1_CAEEL ; P43063, CDK1_CANAL ; P51958, CDK1_CARAU ; DR P13863, CDK1_CHICK ; P34112, CDK1_DICDI ; P23572, CDK1_DROME ; DR Q00646, CDK1_EMENI ; Q8SR86, CDK1_ENCCU ; P06493, CDK1_HUMAN ; DR P11440, CDK1_MOUSE ; Q9DGA5, CDK1_ORYCU ; Q9DGA2, CDK1_ORYJA ; DR Q9DGD3, CDK1_ORYLA ; Q9DG98, CDK1_ORYLU ; Q5RCH1, CDK1_PONAB ; DR Q9W739, CDK1_RANDY ; P39951, CDK1_RAT ; P04551, CDK1_SCHPO ; DR P00546, CDK1_YEAST ; A8WIP6, CDK20_DANRE; Q8IZL9, CDK20_HUMAN; DR Q5EDC3, CDK20_MACMU; Q9JHU3, CDK20_MOUSE; Q5R7I7, CDK20_PONAB; DR Q4KM34, CDK20_RAT ; Q01917, CDK2H_CRIFA; Q4Z6R1, CDK2H_PLABA; DR Q4Y4B1, CDK2H_PLACU; P61075, CDK2H_PLAF7; Q07785, CDK2H_PLAFK; DR O96821, CDK2H_PLAKH; Q9XZD6, CDK2H_PLAVI; Q7RM49, CDK2H_PLAYO; DR Q26671, CDK2H_THEAN; Q27032, CDK2H_THEPA; Q5E9Y0, CDK2_BOVIN ; DR O61847, CDK2_CAEEL ; P43450, CDK2_CARAU ; O55076, CDK2_CRIGR ; DR P23573, CDK2_DROME ; Q04770, CDK2_ENTH1 ; P24941, CDK2_HUMAN ; DR P48963, CDK2_MESAU ; P97377, CDK2_MOUSE ; Q63699, CDK2_RAT ; DR P23437, CDK2_XENLA ; Q00526, CDK3_HUMAN ; Q80YP0, CDK3_MOUSE ; DR Q32KY4, CDK4_BOVIN ; Q9XTR1, CDK4_CAEEL ; P11802, CDK4_HUMAN ; DR P30285, CDK4_MOUSE ; P79432, CDK4_PIG ; P35426, CDK4_RAT ; DR B2MVY4, CDK4_SHEEP ; Q91727, CDK4_XENLA ; P34117, CDK5_DICDI ; DR P48609, CDK5_DROME ; Q2PQN9, CDK5_GLOMM ; Q00534, CDK6_HUMAN ; DR Q64261, CDK6_MOUSE ; G5EFV5, CDK7_CAEEL ; P51953, CDK7_CARAU ; DR P54685, CDK7_DICDI ; P50613, CDK7_HUMAN ; Q03147, CDK7_MOUSE ; DR P51952, CDK7_RAT ; P20911, CDK7_XENLA ; Q17IE8, CDK8_AEDAE ; DR P0C661, CDK8_CAEBR ; P90866, CDK8_CAEEL ; Q8JH47, CDK8_DANRE ; DR Q95YH0, CDK8_DICDI ; Q9VT57, CDK8_DROME ; P49336, CDK8_HUMAN ; DR Q8R3L8, CDK8_MOUSE ; Q66KH9, CDK8_XENLA ; Q6P3N6, CDK8_XENTR ; DR Q4V862, CDK9A_XENLA; Q7ZX42, CDK9B_XENLA; Q5EAB2, CDK9_BOVIN ; DR Q9TVL3, CDK9_CAEEL ; Q5ZKN1, CDK9_CHICK ; Q7SXE8, CDK9_DANRE ; DR P50750, CDK9_HUMAN ; Q99J95, CDK9_MOUSE ; Q641Z4, CDK9_RAT ; DR Q96WV9, CDK9_SCHPO ; Q6GLD8, CDK9_XENTR ; P24100, CDKA1_ARATH; DR P29618, CDKA1_ORYSJ; P29619, CDKA2_ORYSJ; Q9LFT8, CDKC1_ARATH; DR Q6I5Y0, CDKC1_ORYSJ; Q8W4P1, CDKC2_ARATH; Q5JK68, CDKC2_ORYSJ; DR Q6ZAG3, CDKC3_ORYSJ; Q9C9U2, CDKD1_ARATH; A2Y4B6, CDKD1_ORYSI; DR P29620, CDKD1_ORYSJ; Q9C9M7, CDKD2_ARATH; Q9LMT0, CDKD3_ARATH; DR Q84TI6, CDKE1_ARATH; Q336M2, CDKE1_ORYSJ; O80345, CDKF1_ARATH; DR A2YCH5, CDKF1_ORYSI; Q5Z754, CDKF1_ORYSJ; Q2QSL4, CDKF2_ORYSJ; DR Q84SN3, CDKF3_ORYSJ; Q6Z8C8, CDKF4_ORYSJ; Q9FGW5, CDKG1_ARATH; DR A2X6X1, CDKG1_ORYSI; Q6K5F8, CDKG1_ORYSJ; A2XUW1, CDKG2_ORYSI; DR Q7XUF4, CDKG2_ORYSJ; Q9U2H1, CDKL1_CAEEL; Q6AXJ9, CDKL1_DANRE; DR Q00532, CDKL1_HUMAN; Q8CEQ0, CDKL1_MOUSE; Q66HE7, CDKL1_RAT ; DR Q92772, CDKL2_HUMAN; Q4R7T5, CDKL2_MACFA; Q9QUK0, CDKL2_MOUSE; DR Q5R754, CDKL2_PONAB; Q9TTK0, CDKL2_RABIT; Q5XIT0, CDKL2_RAT ; DR Q8IVW4, CDKL3_HUMAN; Q4R8T9, CDKL3_MACFA; Q8BLF2, CDKL3_MOUSE; DR Q9JM01, CDKL3_RAT ; Q5MAI5, CDKL4_HUMAN; Q3TZA2, CDKL4_MOUSE; DR O76039, CDKL5_HUMAN; Q3UTQ8, CDKL5_MOUSE; P25859, CKB11_ARATH; DR Q8L4P8, CKB11_ORYSJ; Q2V419, CKB12_ARATH; Q8LF80, CKB21_ARATH; DR Q0J4I1, CKB21_ORYSJ; Q8LG64, CKB22_ARATH; P36615, CSK1_SCHPO ; DR Q9VPC0, KP58_DROME ; P43294, MHK_ARATH ; Q9UQ07, MOK_HUMAN ; DR Q9WVS4, MOK_MOUSE ; O74456, PEF1_SCHPO ; Q9HGY5, PHO85_CANAX; DR Q6FKD4, PHO85_CANGA; Q6BRY2, PHO85_DEBHA; Q751E8, PHO85_EREGS; DR Q92241, PHO85_KLULA; Q6C7U8, PHO85_YARLI; P17157, PHO85_YEAST; DR A1CL96, SSN3_ASPCL ; Q4WYR6, SSN3_ASPFU ; A2QU77, SSN3_ASPNC ; DR Q2UC58, SSN3_ASPOR ; Q0CQK1, SSN3_ASPTN ; Q5AHK2, SSN3_CANAL ; DR Q6FKC6, SSN3_CANGA ; Q2GYV9, SSN3_CHAGB ; Q1EBK0, SSN3_COCIM ; DR P0CS77, SSN3_CRYNB ; P0CS76, SSN3_CRYNJ ; Q6BM25, SSN3_DEBHA ; DR Q5BAE1, SSN3_EMENI ; Q751F5, SSN3_EREGS ; Q4FCZ5, SSN3_GIBMO ; DR Q6CR51, SSN3_KLULA ; A1D624, SSN3_NEOFI ; Q0TWJ7, SSN3_PHANO ; DR A3LUB9, SSN3_PICST ; A4QXX4, SSN3_PYRO7 ; O13958, SSN3_SCHPO ; DR Q4P9T2, SSN3_USTMA ; Q6CCB0, SSN3_YARLI ; P39073, SSN3_YEAST ; DR Q2YDN8, VRK3_BOVIN ; Q8IV63, VRK3_HUMAN ; Q8K3G5, VRK3_MOUSE ; DR Q54D75, Y2550_DICDI; Q556J6, Y4007_DICDI; Q55FJ6, Y8078_DICDI; DR Q8SRF5, Y823_ENCCU ; Q54Y06, Y8487_DICDI; Q8SR90, Y8H9_ENCCU ; DR Q8SQU8, YBC9_ENCCU ; //