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ENZYME

ENZYME entry: EC 2.7.11.30

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.30
Accepted Name
receptor protein serine/threonine kinase
Alternative Name(s)
activin receptor kinase
receptor serine/threonine protein kinase
receptor type II serine/threonine protein kinase
receptor type I serine/threonine protein kinase
TGF-beta kinase
Reaction catalysed
  • L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)
  • L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)
Comment(s)
  • The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death.
  • Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase.
  • Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.30
EC2PDB2.7.11.30
ExplorEnz2.7.11.30
KEGG Ligand Database for Enzyme Nomenclature2.7.11.30
IUBMB Enzyme Nomenclature2.7.11.30
MEDLINEFind literature relating to 2.7.11.30
MetaCyc2.7.11.30
Rhea expert-curated reactions2.7.11.30
UniProtKB/Swiss-Prot
P36896, ACV1B_HUMANQ61271, ACV1B_MOUSEP80202, ACV1B_RAT
Q8NER5, ACV1C_HUMANQ8K348, ACV1C_MOUSEP70539, ACV1C_RAT
P37023, ACVL1_HUMANQ61288, ACVL1_MOUSEQ5RAN0, ACVL1_PONAB
P80203, ACVL1_RATQ28041, ACVR1_BOVINQ90ZK6, ACVR1_CHICK
Q04771, ACVR1_HUMANP37172, ACVR1_MOUSEP80201, ACVR1_RAT
Q16671, AMHR2_HUMANQ8K592, AMHR2_MOUSEQ28616, AMHR2_RABIT
Q62893, AMHR2_RATQ28043, AVR2A_BOVINQ90669, AVR2A_CHICK
P27037, AVR2A_HUMANP27038, AVR2A_MOUSEP38444, AVR2A_RAT
Q28560, AVR2A_SHEEPP27039, AVR2A_XENLAQ95126, AVR2B_BOVIN
Q90670, AVR2B_CHICKQ13705, AVR2B_HUMANP27040, AVR2B_MOUSE
Q66T47, AVR2B_PIGP38445, AVR2B_RATP27041, AVR2B_XENLA
Q13873, BMPR2_HUMANO35607, BMPR2_MOUSEP36894, BMR1A_HUMAN
P36895, BMR1A_MOUSEQ78EA7, BMR1A_RATQ05438, BMR1B_CHICK
O00238, BMR1B_HUMANP36898, BMR1B_MOUSEP20792, DAF1_CAEEL
P50488, DAF4_CAEELQ09488, SMA6_CAEELO46680, TGFR1_BOVIN
P36897, TGFR1_HUMANQ64729, TGFR1_MOUSEQ5CD18, TGFR1_PIG
P80204, TGFR1_RATQ90999, TGFR2_CHICKP37173, TGFR2_HUMAN
Q62312, TGFR2_MOUSEP38551, TGFR2_PIGP38438, TGFR2_RAT

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