ID   2.7.11.36
DE   MASTL-subfamily protein kinase.
AN   greatwall kinase.
AN   MASTL.
AN   microtubule-associated-subfamily-protein kinase.
CA   (1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
CA   (2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP +
CA   H(+).
CC   -!- Requires Mg(2+).
CC   -!- Peptide array data suggest that MASTL prefers to phosphorylate Ser
CC       over Thr, followed at position +1 by a bulky hydrophobic (Met, Leu,
CC       Phe or Tyr) and with an aromatic residue in the -2 position.
CC   -!- Its main role in animal systems is in the regulation of mitosis by
CC       phosphorylating a conserved site on endosulfine family proteins (ENSA
CC       and ARPP-19 in human), causing them to inhibit the protein
CC       phosphatase 2A-B55 [protein phosphatase 2A (PP2A) holoenzyme complex
CC       containing a B55-family regulatory subunit].
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