ID   2.7.11.37
DE   MAST-subfamily kinase.
AN   microtubule-associated serine/threonine-protein kinase.
CA   (1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
CA   (2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP +
CA   H(+).
CC   -!- MAST (Microtubule Associated Serine/Threonine) kinases are
CC       eukaryotic-wide kinases with roles in microtubule function, PTEN
CC       regulation and a variety of neuronal functions.
CC   -!- They are found in most eukaryotes, though lost from most fungi and
CC       ciliates.
CC   -!- MAST kinases associate with their substrates via their PDZ domains.
CC   -!- Substrates include EC 3.1.3.67 in human and nematodes, and Dlic
CC       (Dynein light intermediate chain) in Drosophila. The latter is
CC       phosphorylated on Ser(401).
//