ID   2.7.11.38
DE   NEK9 subfamily protein kinase.
CA   (1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
CA   (2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP +
CA   H(+).
CC   -!- This enzyme is found in animals and choanoflagellates, although it
CC       has been lost in arthropods and nematodes. It is implicated in
CC       centrosome separation and cilium formation.
CC   -!- In peptide arrays, the enzyme prefers to phosphorylate Ser, with
CC       acidic residues at -2 and -4/-5, similar to that of the NEK6 protein
CC       kinase subfamily. NEK9 can autophosphorylate.
CC   -!- Substrates in humans include the microtubule-associated protein
CC       kinases NEK6/7, the microtubule-associated protein spindle assembly
CC       protein TPX2, the gamma-tubulin associated protein NEDD1, which is
CC       required for mitotic spindle assembly and function and the LC3B
CC       protein, which is involved in autophagy substrate selection and
CC       autophagosome biogenesis.
DR   Q8TD19, NEK9_HUMAN ;  Q8K1R7, NEK9_MOUSE ;  Q7ZZC8, NEK9_XENLA ;
//