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ENZYME

ENZYME entry: EC 2.7.11.7

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.7
Accepted Name
[myosin heavy-chain] kinase
Alternative Name(s)
calmodulin-dependent myosin heavy chain kinase
MHCK
MIHC kinase
myosin heavy chain kinase
myosin heavy-chain kinase
myosin heavy chain kinase A
myosin I heavy-chain kinase
myosin II heavy-chain kinase
Reaction catalysed
L-threonyl-[myosin heavy-chain] + ATP = O-phospho-L-threonyl-[myosin heavy-chain] + ADP + H(+)
Comment(s)
  • The enzyme from Dictyostelium sp. (slime molds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin.
  • One threonine residue in each heavy chain acts as acceptor.
  • While the enzyme from some species is activated by actin, in other cases Ca(2+)/calmodulin are required for activity.
  • Formerly EC 2.7.1.129.
Cross-references
BRENDA2.7.11.7
EC2PDB2.7.11.7
ExplorEnz2.7.11.7
KEGG Ligand Database for Enzyme Nomenclature2.7.11.7
IUBMB Enzyme Nomenclature2.7.11.7
MEDLINEFind literature relating to 2.7.11.7
MetaCyc2.7.11.7
Rhea expert-curated reactions2.7.11.7
UniProtKB/Swiss-Prot
P42527, MHCKA_DICDIP90648, MHCKB_DICDIQ8MY12, MHCKC_DICDI
Q54SF9, MHCKD_DICDI

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