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ENZYME entry: EC 2.7.11.8

Accepted Name
Fas-activated serine/threonine kinase.
Alternative Name(s)
FAST.
FASTK.
Reaction catalysed
  • ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]
  • ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]
Comment(s)
  • This enzyme is activated during Fas-mediated apoptosis.
  • Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein.
  • Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
  • Formerly EC 2.7.1.37.
Cross-references
BRENDA2.7.11.8
EC2PDB2.7.11.8
ExplorEnz2.7.11.8
PRIAM enzyme-specific profiles2.7.11.8
KEGG Ligand Database for Enzyme Nomenclature2.7.11.8
IUBMB Enzyme Nomenclature2.7.11.8
IntEnz2.7.11.8
MEDLINEFind literature relating to 2.7.11.8
MetaCyc2.7.11.8
Rhea expert-curated reactions2.7.11.8
UniProtKB/Swiss-Prot
Q14296, FASTK_HUMAN;  Q9JIX9, FASTK_MOUSE;  

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