ENZYME entry: EC 2.7.11.8
Accepted Name |
Fas-activated serine/threonine kinase.
|
Alternative Name(s) |
FAST. |
FASTK. |
Reaction catalysed |
- ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]
- ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]
|
Comment(s) |
- This enzyme is activated during Fas-mediated apoptosis.
- Following Fas ligation, the enzyme, which is constitutively
phosphorylated, is dephosphorylated, and it is the dephosphorylated
form that causes phosphorylation of TIA-1, a nuclear RNA-binding
protein.
- Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
- Formerly EC 2.7.1.37.
|
Cross-references |
BRENDA | 2.7.11.8 |
EC2PDB | 2.7.11.8 |
ExplorEnz | 2.7.11.8 |
PRIAM enzyme-specific profiles | 2.7.11.8 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.8 |
IUBMB Enzyme Nomenclature | 2.7.11.8 |
IntEnz | 2.7.11.8 |
MEDLINE | Find literature relating to 2.7.11.8 |
MetaCyc | 2.7.11.8 |
Rhea expert-curated reactions | 2.7.11.8 |
UniProtKB/Swiss-Prot |
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