ID 2.7.12.1 DE dual-specificity kinase. CA (1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]. CA (2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl- CA [protein]. CA (3) ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CA [protein]. CC -!- This family of enzymes can phosphorylate both Ser/Thr and Tyr CC residues. CC -!- Formerly EC 2.7.1.37. DR P51566, AFC1_ARATH ; P51567, AFC2_ARATH ; P51568, AFC3_ARATH ; DR P49759, CLK1_HUMAN ; P22518, CLK1_MOUSE ; P49760, CLK2_HUMAN ; DR O35491, CLK2_MOUSE ; Q3SX21, CLK3_BOVIN ; P49761, CLK3_HUMAN ; DR O35492, CLK3_MOUSE ; Q63117, CLK3_RAT ; Q9HAZ1, CLK4_HUMAN ; DR O35493, CLK4_MOUSE ; P49762, DOA_DROME ; Q1L6Q1, DUSTY_APIME; DR Q4TVR5, DUSTY_BOVIN; Q4VSN4, DUSTY_CANLF; Q6XUX0, DUSTY_CHICK; DR Q4VSN1, DUSTY_DANRE; Q6XUX3, DUSTY_HUMAN; Q20CR4, DUSTY_MACMU; DR Q6XUX1, DUSTY_MOUSE; Q4VSN5, DUSTY_PANTR; A2CI34, DUSTY_PIMPR; DR Q6XUX2, DUSTY_RAT ; A2CI35, DUSTY_STRPU; Q4VSN2, DUSTY_TAKRU; DR Q4VSN3, DUSTY_TETNG; Q67E01, DUSTY_XENLA; Q67E00, DUSTY_XENTR; DR Q13627, DYR1A_HUMAN; Q61214, DYR1A_MOUSE; P85051, DYR1A_RABIT; DR Q63470, DYR1A_RAT ; Q2TAE3, DYR1A_XENLA; Q0IJ08, DYR1A_XENTR; DR Q9Y463, DYR1B_HUMAN; Q9Z188, DYR1B_MOUSE; Q76NV1, DYRK1_DICDI; DR Q5ZIU3, DYRK2_CHICK; Q54BC9, DYRK2_DICDI; Q9V3D5, DYRK2_DROME; DR Q92630, DYRK2_HUMAN; Q5U4C9, DYRK2_MOUSE; P83102, DYRK3_DROME; DR O43781, DYRK3_HUMAN; Q4R6S5, DYRK3_MACFA; Q922Y0, DYRK3_MOUSE; DR Q4V8A3, DYRK3_RAT ; Q9NR20, DYRK4_HUMAN; Q8BI55, DYRK4_MOUSE; DR P32350, KNS1_YEAST ; Q10156, LKH1_SCHPO ; A8X4H1, MBK1_CAEBR ; DR Q8WQL7, MBK1_CAEEL ; A8WJR8, MBK2_CAEBR ; Q9XTF3, MBK2_CAEEL ; DR P21965, MCK1_YEAST ; P49657, MNB_DROME ; O94235, MPS1_SCHPO ; DR Q09690, POM1_SCHPO ; Q54I36, PYK3_DICDI ; P22216, RAD53_YEAST; DR O64782, SD129_ARATH; A2XW02, STRK1_ORYSI; Q7XR88, STRK1_ORYSJ; DR Q15569, TESK1_HUMAN; O70146, TESK1_MOUSE; Q63572, TESK1_RAT ; DR Q96S53, TESK2_HUMAN; Q8VCT9, TESK2_MOUSE; Q924U5, TESK2_RAT ; DR Q8AYG3, TTK_DANRE ; P33981, TTK_HUMAN ; Q4R945, TTK_MACFA ; DR P35761, TTK_MOUSE ; Q8RWH3, YAK1_ARATH ; Q8SQZ4, YAK1_ENCCU ; DR P14680, YAK1_YEAST ; Q54QV3, YAKA_DICDI ; Q75JK0, ZAK1_DICDI ; DR Q552C6, ZAK2_DICDI ; //