ID   2.7.12.2
DE   mitogen-activated protein kinase kinase.
AN   MAP2K.
AN   MAP kinase kinase.
AN   MAPKK.
AN   MEK.
AN   MKK.
CA   (1) ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].
CA   (2) ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-
CA   [protein].
CA   (3) ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CA   [protein].
CC   -!- A dual-specific protein kinase and requires mitogen-activated protein
CC       kinase kinase kinase (MAPKKK) for activation.
CC   -!- It is required for activation of EC 2.7.11.24.
CC   -!- Phosphorylation of MEK1 by Raf involves phosphorylation of two serine
CC       residues.
CC   -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways
CC       are among the most widespread mechanisms of cellular regulation.
CC   -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli
CC       including hormones (e.g. insulin and growth hormone), mitogens (e.g.
CC       epidermal growth factor and platelet-derived growth factor),
CC       vasoactive peptides (e.g. angiotensin-II and endothelin),
CC       inflammatory cytokines of the tumor necrosis factor (TNF) family and
CC       environmental stresses such as osmotic shock, ionizing radiation and
CC       ischemeic injury.
DR   P10506, BYR1_SCHPO ;  Q24324, DSOR1_DROME;  Q99078, FUZ7_USTMA ;
DR   Q23977, HEP_DROME  ;  G5EDT6, JKK1_CAEEL ;  Q9LQM8, M2K10_ARATH;
DR   A9RWC9, M2K1A_PHYPA;  A9SR33, M2K1B_PHYPA;  A9S5R3, M2K1C_PHYPA;
DR   Q94A06, M2K1_ARATH ;  Q5QN75, M2K1_ORYSJ ;  Q9S7U9, M2K2_ARATH ;
DR   O80396, M2K3_ARATH ;  O80397, M2K4_ARATH ;  Q8RXG3, M2K5_ARATH ;
DR   Q9FJV0, M2K6_ARATH ;  Q9LPQ3, M2K7_ARATH ;  Q9M8J5, M2K8_ARATH ;
DR   Q9FX43, M2K9_ARATH ;  Q21307, MEK1_CAEEL ;  Q10664, MEK2_CAEEL ;
DR   P32490, MKK1_YEAST ;  P32491, MKK2_YEAST ;  Q20347, MKK4_CAEEL ;
DR   Q9GRT1, MKK4_LEIME ;  Q0PKV7, MKK5_LEIME ;  Q63980, MP2K1_CRIGR;
DR   Q55CL6, MP2K1_DICDI;  Q02750, MP2K1_HUMAN;  P31938, MP2K1_MOUSE;
DR   Q9XT09, MP2K1_PANTR;  P29678, MP2K1_RABIT;  Q01986, MP2K1_RAT  ;
DR   Q91447, MP2K1_SERCA;  Q05116, MP2K1_XENLA;  Q1HG70, MP2K2_CANLF;
DR   Q90891, MP2K2_CHICK;  Q90321, MP2K2_CYPCA;  P36507, MP2K2_HUMAN;
DR   Q63932, MP2K2_MOUSE;  P36506, MP2K2_RAT  ;  Q07192, MP2K2_XENLA;
DR   P46734, MP2K3_HUMAN;  O09110, MP2K3_MOUSE;  P39746, MP2K3_XENLA;
DR   P45985, MP2K4_HUMAN;  P47809, MP2K4_MOUSE;  Q13163, MP2K5_HUMAN;
DR   Q9WVS7, MP2K5_MOUSE;  Q62862, MP2K5_RAT  ;  Q5E9X2, MP2K6_BOVIN;
DR   Q9DGE0, MP2K6_DANRE;  P52564, MP2K6_HUMAN;  P70236, MP2K6_MOUSE;
DR   O14733, MP2K7_HUMAN;  Q8CE90, MP2K7_MOUSE;  Q4KSH7, MP2K7_RAT  ;
DR   Q84VX4, MPS1_ARATH ;  Q8SSH4, MPS1_ENCCU ;  P54199, MPS1_YEAST ;
DR   P08018, PBS2_YEAST ;  G5EDF7, SEK1_CAEEL ;  A0A1S4CGX4, SIPKK_TOBAC;
DR   A0A1S3Z5Y0, SIPK_TOBAC ;  Q9Y884, SKH1_SCHPO ;  Q5A6T5, STE7_CANAL ;
DR   C4YLK8, STE7_CANAW ;  P0CY25, STE7_CANAX ;  P06784, STE7_YEAST ;
DR   Q6DHU8, TOPK_DANRE ;  Q96KB5, TOPK_HUMAN ;  Q9JJ78, TOPK_MOUSE ;
DR   P33886, WIS1_SCHPO ;
//