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ENZYME

ENZYME entry: EC 2.7.13.3

Accepted Name
histidine kinase
Alternative Name(s)
histidine protein kinase
HK1
protein histidine kinase
protein kinase
protein kinase (histidine)
Reaction catalysed
ATP + protein L-histidine <=> ADP + protein N-phospho-L-histidine
Comment(s)
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
Cross-references
BRENDA2.7.13.3
EC2PDB2.7.13.3
ExplorEnz2.7.13.3
PRIAM enzyme-specific profiles2.7.13.3
KEGG Ligand Database for Enzyme Nomenclature2.7.13.3
IUBMB Enzyme Nomenclature2.7.13.3
IntEnz2.7.13.3
MEDLINEFind literature relating to 2.7.13.3
MetaCyc2.7.13.3
Rhea expert-curated reactions2.7.13.3
UniProtKB/Swiss-Prot
Q04943, AFSQ2_STRCOQ9SXL4, AHK1_ARATHQ9C5U2, AHK2_ARATH
Q9C5U1, AHK3_ARATHQ9C5U0, AHK4_ARATHQ3S4A7, AHK5_ARATH
P58363, ARCB_ECO57P0AEC3, ARCB_ECOLIP44578, ARCB_HAEIN
P0AEC4, ARCB_SHIFLQ2FH24, ARLS_STAA3Q9KJN3, ARLS_STAA8
Q2YY04, ARLS_STAABQ5HG05, ARLS_STAACQ7A2R7, ARLS_STAAM
Q7A5N3, ARLS_STAANQ6GGZ4, ARLS_STAARQ6G9E7, ARLS_STAAS
Q7A0W5, ARLS_STAAWQ5HPC4, ARLS_STAEQQ8CSL7, ARLS_STAES
Q4L6C5, ARLS_STAHJQ49XM6, ARLS_STAS1O24972, ARSS_HELPY
Q9HUI3, ARUS_PSEAEQ06067, ATOS_ECOLIQ2T0V9, ATSR_BURTA
P30847, BAES_ECOLIP0AEC7, BARA_ECO57P0AEC6, BARA_ECOL6
P0AEC5, BARA_ECOLIP59342, BARA_SHIFLP30844, BASS_ECOLI
P36557, BASS_SALTYO35044, BCES_BACSUQ9K620, BCES_HALH5
Q9RZA4, BPHY_DEIRAQ9HWR3, BPHY_PSEAEP0AD15, BTSS_ECOL6
P0AD14, BTSS_ECOLIP0AD16, BTSS_SHIFLP26762, BVGS_BORBR
P40330, BVGS_BORPAP16575, BVGS_BORPEQ9I0I2, CARS_PSEAE
P0DOA0, CCKA_BRUA2O25153, CHEAY_HELPYP29072, CHEA_BACSU
Q44737, CHEA_BORBUQ53135, CHEA_CERSPP07363, CHEA_ECOLI
B0R4J9, CHEA_HALS3P21813, CHEA_KLEAKQ92DW2, CHEA_LISIN
Q48768, CHEA_LISMOQ52880, CHEA_RHIMEP09384, CHEA_SALTY
Q56310, CHEA_THEMAP96123, CHEA_TREPAQ5AHA0, CHK1_CANAL
Q07737, CHVG_AGRFCP72292, CHVG_RHIMEP0A4I5, CIAH_STRPN
P0A4I6, CIAH_STRR6Q9KHI5, CIKA_SYNE7P74111, CIKA_SYNY3
Q8DKG0, CIKA_THEVBP52687, CITA_KLEPNO34427, CITS_BACSU
Q9RC53, CITS_HALH5O22267, CKI1_ARATHQ99027, COMP_BACSU
Q02541, COPS_PSEUBP0AE84, CPXA_ECO57P0AE83, CPXA_ECOL6
P0AE82, CPXA_ECOLIA7N6S2, CQSS_VIBC1Q9KM66, CQSS_VIBCH
O25917, CRDS_HELPYP08401, CREC_ECOLIQ82EB2, CSEC_STRAW
Q9ZEP3, CSEC_STRCOB7GDS0, CSK_PHATCO32193, CSSS_BACSU
Q8XBY4, CUSS_ECO57Q8FK37, CUSS_ECOL6P77485, CUSS_ECOLI
P0A4I7, CUTS_STRCOP0A4I8, CUTS_STRLIQ44007, CZCS_CUPMC
Q9HU20, DCTB_PSEAEP10047, DCTB_RHILEP13633, DCTB_RHIME
P96601, DCTS_BACSUQ9K997, DCTS_HALH5P37739, DCTS_RHOCA
P0AEC9, DCUS_ECO57P59340, DCUS_ECOL6P0AEC8, DCUS_ECOLI
P59341, DCUS_SHIFLQ03069, DEGM_BACB2P13799, DEGS_BACSU
P54663, DEGS_BREBEO34757, DESK_BACSUP9WGK2, DEVS_MYCTO
P9WGK3, DEVS_MYCTUQ54U87, DHKA_DICDIQ54YH4, DHKB_DICDI
Q95PI2, DHKC_DICDIQ54SP4, DHKD_DICDIQ55E44, DHKE_DICDI
Q551X9, DHKF_DICDIQ54Q69, DHKG_DICDIQ54W36, DHKH_DICDI
Q86AT9, DHKI_DICDIQ54YZ9, DHKJ_DICDIQ86CZ2, DHKK_DICDI
Q54RP6, DHKL_DICDIQ54SK5, DHKM_DICDIQ03228, DIVJ_CAUVC
Q9RQQ9, DIVL_CAUVCQ8E3C7, DLTS_STRA3Q8DXQ8, DLTS_STRA5
P9WGK1, DOST_MYCTUP77510, DPIB_ECOLIP20169, DSPA_SYNY3
P0AEJ4, ENVZ_ECOLIP41406, ENVZ_SALTIA0A0H3NIL4, ENVZ_SALTS
P08982, ENVZ_SALTYP0AEJ5, ENVZ_SHIFLA0A4P7TSF2, ENVZ_SHIFM
Q38846, ERS1_ARATHA2XL32, ERS1_ORYSIQ53RH0, ERS1_ORYSJ
B8AY75, ERS2_ORYSIQ0DKM0, ERS2_ORYSJP49333, ETR1_ARATH
O49230, ETR1_BRAOLO82436, ETR1_CUCMNQ9SSY6, ETR1_CUCSA
O81122, ETR1_MALDOQ9ZWL6, ETR1_PASEDQ9XH58, ETR1_PELHO
Q9M7M1, ETR1_PRUPEQ41342, ETR1_SOLLCO48929, ETR1_TOBAC
Q8H1X1, ETR2_ORYSIQ7XX84, ETR2_ORYSJQ9XH57, ETR2_PELHO
O49187, ETR2_SOLLCQ6T5K2, ETR3_ORYSIQ0DWC7, ETR3_ORYSJ
Q6T5K3, ETR4_ORYSIQ7F239, ETR4_ORYSJP58402, EVGS_ECO57
P30855, EVGS_ECOLIE5KK10, FILI_METH6P26489, FIXL_AZOC5
P23222, FIXL_BRADUP10955, FIXL_RHIMEQ9I4N4, FLES_PSEAE
O25026, FLGS_HELPYP18769, FRZE_MYXXAQ9F8D7, GACS_PSEPH
P48027, GACS_PSESYA7HD43, GCHK_ANADFP40758, GLNK_BACSU
P52101, GLRK_ECOLIA7WZC5, GRAS_STAA1A6TZD7, GRAS_STAA2
Q2FIX9, GRAS_STAA3Q2G0D9, GRAS_STAA8A5IQL3, GRAS_STAA9
Q2YSS1, GRAS_STAABQ5HI08, GRAS_STAACA6QEW9, GRAS_STAAE
Q99VW1, GRAS_STAAMQ7A6Z3, GRAS_STAANQ6GJ10, GRAS_STAAR
Q6GBH0, GRAS_STAASA8Z182, GRAS_STAATQ8NXR5, GRAS_STAAW
Q5HR80, GRAS_STAEQQ8CTL4, GRAS_STAESQ4L482, GRAS_STAHJ
Q49VK4, GRAS_STAS1Q44930, GTCS_ANEMIQ9HZ47, GTRS_PSEAE
Q9AWA5, GWD1_SOLTUP73276, HIK2_SYNY3Q8DMC5, HIK2_THEVB
P74199, HIK34_SYNY3A0A0H2ZM62, HK06_STRP2Q8DN03, HK06_STRR6
Q7D9K1, HK12_MYCTOO07778, HK1_MYCTUO07777, HK2_MYCTU
P76339, HPRS_ECOLIQ2FK46, HPTS_STAA3Q2G1E0, HPTS_STAA8
Q2YV55, HPTS_STAABQ5HJF6, HPTS_STAACQ99WZ9, HPTS_STAAM
Q7A7X8, HPTS_STAANQ6GK92, HPTS_STAARQ6GCQ2, HPTS_STAAS
Q8NYJ8, HPTS_STAAWA7X5Y6, HSSS_STAA1A6U489, HSSS_STAA2
Q2FED4, HSSS_STAA3Q2FVQ8, HSSS_STAA8A5IVE3, HSSS_STAA9
Q2YZ23, HSSS_STAABQ5HDJ3, HSSS_STAACA6QJK4, HSSS_STAAE
Q99RR5, HSSS_STAAMQ7A3X0, HSSS_STAANQ6GE72, HSSS_STAAR
Q6G6V8, HSSS_STAASA8Z553, HSSS_STAATQ8NV46, HSSS_STAAW
Q5HLN1, HSSS_STAEQQ8CRA8, HSSS_STAESQ4L8M0, HSSS_STAHJ
Q49ZT9, HSSS_STAS1I1WSZ3, IRLS_BURP2P0DMK6, IRLS_BURPS
P94608, KDPD_CLOABP21865, KDPD_ECOLIP9WGL2, KDPD_MYCTO
P9WGL3, KDPD_MYCTUO34971, KDPD_RATRAQ2FWH7, KDPD_STAA8
P16497, KINA_BACSUQ08430, KINB_BACSUO34206, KINB_PSEAI
P39764, KINC_BACSUO31671, KIND_BACSUO31661, KINE_BACSU
O32198, LIAS_BACSUP94438, LNRJ_BACSUB2SB67, LOVHK_BRUA1
Q2YKK7, LOVHK_BRUA2A6X554, LOVHK_BRUA4Q577Y7, LOVHK_BRUAB
A9MBM8, LOVHK_BRUC2Q8YC53, LOVHK_BRUMEA5VUS1, LOVHK_BRUO2
A9WYQ7, LOVHK_BRUSIQ8FW73, LOVHK_BRUSUQ48IV1, LOVHK_PSE14
Q881J7, LOVHK_PSESMQ4ZSY3, LOVHK_PSEU2Q1M667, LOVHK_RHIL3
A7MRY4, LUXN_VIBC1P0C5S6, LUXN_VIBHAQ9KLK7, LUXQ_VIBCH
P54302, LUXQ_VIBHAQ87GU5, LUXQ_VIBPAQ8D5Z6, LUXQ_VIBVU
Q7MD16, LUXQ_VIBVYQ2NCA3, LVHK1_ERYLHQ2NB77, LVHK2_ERYLH
Q81JL2, LYTS_BACANQ814J0, LYTS_BACCRP94513, LYTS_BACSU
Q82Z75, LYTS_ENTFAQ8EQQ2, LYTS_OCEIHQ2FK10, LYTS_STAA3
Q53705, LYTS_STAA8Q2YV68, LYTS_STAABQ5HJB6, LYTS_STAAC
P60612, LYTS_STAAMP60613, LYTS_STAANQ6GK52, LYTS_STAAR
Q6GCL2, LYTS_STAASP60614, LYTS_STAAWQ5HLG3, LYTS_STAEQ
Q8CR79, LYTS_STAESQ4L8V3, LYTS_STAHJQ4A009, LYTS_STAS1
Q8E7H4, LYTS_STRA3Q8E218, LYTS_STRA5Q8DVB6, LYTS_STRMU
Q9P7Q7, MAK1_SCHPOO14002, MAK2_SCHPOO74539, MAK3_SCHPO
O05250, MALK_BACSUQ1M799, MCTS_RHIL3A0QBR0, MPRB_MYCA1
Q7U0X3, MPRB_MYCBOA1KHB8, MPRB_MYCBPQ9Z5G7, MPRB_MYCLE
Q742C0, MPRB_MYCPAA0R3I7, MPRB_MYCS2A3Q5L8, MPRB_MYCSJ
A1UL69, MPRB_MYCSKQ1B3X9, MPRB_MYCSSA5U124, MPRB_MYCTA
P9WGL0, MPRB_MYCTOP9WGL1, MPRB_MYCTUA0PWB3, MPRB_MYCUA
A1TEL6, MPRB_MYCVPQ8THF6, MSMS_METACP59963, MTRB_MYCBO
Q9CCJ1, MTRB_MYCLEQ93CB7, MTRB_MYCPAA0QTK3, MTRB_MYCS2
P9WGK8, MTRB_MYCTOP9WGK9, MTRB_MYCTUP27896, NARQ_ECOLI
P44604, NARQ_HAEINO53857, NARS_MYCTUP0AFA3, NARX_ECO57
P0AFA2, NARX_ECOLIP0AFA4, NARX_SHIFLP70954, NATK_BACSU
Q3T0Q4, NDKB_BOVINQ50KA8, NDKB_CANLFP22392, NDKB_HUMAN
Q01768, NDKB_MOUSEQ2EN76, NDKB_PIGQ5RFH3, NDKB_PONAB
P19804, NDKB_RATP30663, NIFL_AZOVIQ5A599, NIK1_CANAL
P42707, NISK_LACLLP15939, NODV_BRADUA7X624, NREB_STAA1
A6U4C1, NREB_STAA2Q2FEA5, NREB_STAA3Q2FVM6, NREB_STAA8
A5IVH3, NREB_STAA9Q2YZ41, NREB_STAABQ5HDG4, NREB_STAAC
A6QJN2, NREB_STAAEQ931F6, NREB_STAAMQ99RN7, NREB_STAAN
Q6GE41, NREB_STAARQ6G6S9, NREB_STAASA8Z581, NREB_STAAT
Q7A028, NREB_STAAWQ7WZY5, NREB_STACTQ5HLK5, NREB_STAEQ
Q8CR97, NREB_STAESQ4L8Q7, NREB_STAHJP45670, NTRB_AZOBR
P10578, NTRB_BRASRP0AFB6, NTRB_ECO57P0AFB5, NTRB_ECOLI
P06218, NTRB_KLEOXP28788, NTRB_PROHUP41503, NTRB_RHILP
Q52977, NTRB_RHIMEP09431, NTRB_RHOCBP0A2E0, NTRB_SALTI
P0A2D9, NTRB_SALTYP0AFB7, NTRB_SHIFLP19906, NTRB_VIBAL
Q1RJB3, NTRYL_RICBRQ92H24, NTRYL_RICCNQ4UMD4, NTRYL_RICFE
Q9ZCU7, NTRYL_RICPRQ68WC5, NTRYL_RICTYP45675, NTRY_AZOBR
Q04850, NTRY_AZOC5A2YFR6, OHK1_ORYSIA3BE68, OHK1_ORYSJ
A2YA15, OHK2_ORYSIQ5SML4, OHK2_ORYSJA2WYI4, OHK3_ORYSI
A1A696, OHK3_ORYSJA1A698, OHK4_ORYSJA1A697, OHK5_ORYSJ
A1A699, OHK6_ORYSJQ47457, PCOS_ECOLXB2S758, PDHS_BRUA1
Q2YRB4, PDHS_BRUA2A6X5X4, PDHS_BRUA4Q57BR6, PDHS_BRUAB
A9M715, PDHS_BRUC2Q8YIM6, PDHS_BRUMEA5VRX4, PDHS_BRUO2
B0CI82, PDHS_BRUSIQ8FZ86, PDHS_BRUSUA0QTP6, PDTAS_MYCS2
P9WGL4, PDTAS_MYCTOP9WGL5, PDTAS_MYCTUQ04804, PFES_PSEAE
P37433, PGTB_SALTYQ8X739, PHOQ_ECO57Q8FIB8, PHOQ_ECOL6
P23837, PHOQ_ECOLIQ9I4F8, PHOQ_PSEAEQ57QC4, PHOQ_SALCH
Q5PMJ0, PHOQ_SALPAD0ZV89, PHOQ_SALT1Q8Z7H3, PHOQ_SALTI
E1WFA0, PHOQ_SALTSF5ZP94, PHOQ_SALTUP0DM80, PHOQ_SALTY
Q83RR1, PHOQ_SHIFLP23545, PHOR_BACSUP08400, PHOR_ECOLI
P71380, PHOR_HAEINP45608, PHOR_KLEPNP23621, PHOR_PSEAE
P45609, PHOR_SHIDYQ55168, PHY1_SYNY3Q9LCC2, PHYA_NOSS1
Q9R6X3, PHYB_NOSS1P33639, PILS_PSEAEP37894, PLEC_CAUVC
T2KMF4, PLH4_FORAGQ70FG9, PMRB_PECPMQ9HV31, PMRB_PSEAE
Q9HWA7, PPRA_PSEAEP0A5Z9, PRRB_MYCBOO33071, PRRB_MYCLE
P9WGK6, PRRB_MYCTOP9WGK7, PRRB_MYCTUQ8X524, QSEC_ECO57
P40719, QSEC_ECOLIP45336, QSEC_HAEINQ8Z3P2, QSEC_SALTI
Q8ZLZ9, QSEC_SALTYQ8XA47, QSEE_ECO57P0DMC5, RCSC_ECOLI
P0DMC6, RCSC_ECOLXQ56128, RCSC_SALTIP58662, RCSC_SALTY
Q3J6C1, REGB_CERS4P0C0Z0, REGB_CERSPP35164, RESE_BACSU
P0C0F7, RPFC_XANC8P0C0F6, RPFC_XANCPQ55932, RPPB_SYNY3
Q08408, RPRX_BACFRQ8GP19, RSSA_SERMAP18392, RSTB_ECOLI
Q2FIT5, SAES_STAA3Q2G2U1, SAES_STAA8Q2YSM6, SAES_STAAB
Q5HHW5, SAES_STAACQ840P7, SAES_STAAEQ99VR8, SAES_STAAM
Q7A6V4, SAES_STAANQ6GIT7, SAES_STAARQ6GBC5, SAES_STAAS
Q7A1J2, SAES_STAAWQ5HR29, SAES_STAEQQ8CTI3, SAES_STAES
B1WYT4, SASA_CROS5B7KFU0, SASA_GLOC7B0JK50, SASA_MICAN
B2J946, SASA_NOSP7Q8YR50, SASA_NOSS1Q7U871, SASA_PARMW
A3PDI2, SASA_PROM0A8G5E7, SASA_PROM2A2C884, SASA_PROM3
Q31AE8, SASA_PROM9Q7BWI3, SASA_PROMAQ7V6P7, SASA_PROMM
Q7V113, SASA_PROMPA2BRQ6, SASA_PROMSB7K3M6, SASA_RIPO1
Q06904, SASA_SYNE7Q2JWK9, SASA_SYNJAQ2JKD9, SASA_SYNJB
Q0IBF4, SASA_SYNS3Q3AYV8, SASA_SYNS9Q55630, SASA_SYNY3
Q8DMT2, SASA_THEVBQ3M8A7, SASA_TRIV2P0A601, SENX3_MYCBO
P54883, SENX3_MYCLEA0QR01, SENX3_MYCS2P9WGK4, SENX3_MYCTO
P9WGK5, SENX3_MYCTUQ9ZHD4, SILS_SALTMQ5A872, SLN1_CANAL
P39928, SLN1_YEASTP33113, SPAK_BACIUP39664, SPHS_SYNE7
Q2FY80, SRRB_STAA8Q5HFT1, SRRB_STAACQ99TZ9, SRRB_STAAM
Q7A5H7, SRRB_STAANQ6GGK7, SRRB_STAARQ6G973, SRRB_STAAS
Q9L523, SRRB_STAAUQ8NWF3, SRRB_STAAWO69729, TCRY_MYCTU
Q9P896, TCSA_EMENIQ9P4U6, TCSB_EMENIO87939, TDIS_THAAR
Q8KIY1, TMOS_PSEMEA5W4E3, TODS_PSEP1E0X9C7, TODS_PSEPT
P58356, TORS_ECO57P39453, TORS_ECOLIP96368, TRCS_MYCTU
Q8ZPP6, TTRS_SALTYP09835, UHPB_ECOLIP27668, UHPB_SALTY
Q47745, VANS_ENTFAQ06240, VANS_ENTFCP07167, VIRAL_RHIRD
P07168, VIRAW_RHIRDP18540, VIRA_AGRFCP10799, VIRA_AGRT9
Q9KWK8, VRAS_STAA1Q5HEN9, VRAS_STAACQ7A2Q0, VRAS_STAAM
Q99SZ7, VRAS_STAANQ6GFH2, VRAS_STAARQ6G849, VRAS_STAAS
Q7A0H9, VRAS_STAAWQ5HN49, VRAS_STAEQQ8CRV2, VRAS_STAES
Q4L7J6, VRAS_STAHJQ49YT0, VRAS_STAS1Q9KM24, VXRA_VIBCH
Q45614, WALK_BACSUA5A2P0, WALK_MAMSCA7WWQ7, WALK_STAA1
A6TXG9, WALK_STAA2Q2FKN7, WALK_STAA3Q2G2U4, WALK_STAA8
A5INR0, WALK_STAA9Q2YUQ2, WALK_STAABQ5HJX6, WALK_STAAC
A6QD58, WALK_STAAEQ7A305, WALK_STAAMQ7A8E0, WALK_STAAN
Q6GKS6, WALK_STAARQ6GD71, WALK_STAASA8YYU2, WALK_STAAT
Q9RDT3, WALK_STAAUQ7A215, WALK_STAAWQ5HK19, WALK_STAEQ
Q8CU87, WALK_STAESQ4LAJ8, WALK_STAHJQ4A159, WALK_STAS1
A0A0H2ZNH9, WALK_STRP2Q8DPL8, WALK_STRR6Q52969, Y1002_RHIME
Q8CU03, Y166_STAESQ5HKE1, Y2405_STAEQQ02482, Y3689_SHEFN
O31433, YBDK_BACSUP42245, YCBM_BACSUQ1XD95, YCF26_NEOYE
P51392, YCF26_PORPUP94414, YCLK_BACSUP96685, YDFH_BACSU
O31516, YESM_BACSUO07527, YHCY_BACSUO34638, YKOH_BACSU
P0AA94, YPDA_ECO57P0AA93, YPDA_ECOLIP54444, YRKQ_BACSU
O06979, YVCQ_BACSUQ795K2, YVFT_BACSUO34989, YVRG_BACSU
P42422, YXDK_BACSUP55183, YXJM_BACSUQ8X614, ZRAS_ECO57
P14377, ZRAS_ECOLIQ9APE0, ZRAS_KLEOXQ8Z332, ZRAS_SALTI
P37461, ZRAS_SALTY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.13.-
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