| Accepted Name |
|---|
| fatty acid kinase
|
| Reaction catalysed |
|---|
| a fatty acid + ATP = a fatty acyl phosphate + ADP |
| Comment(s) |
|---|
- The enzyme is a dimeric complex consisting of an ATP-binding protein
(FakA) and a fatty acid-binding protein (FakB).
- The first step in the reaction is the binding of FakB (with a bound
fatty acid) to FakA.
- The fatty acid bound to FakB is then phosphorylated by FakA, and the
fatty acyl phosphate-bound FakB is released from the complex.
- In the presence of an exchangeable fatty acid pool in the cell
membrane, the fatty acy phosphate bound to FakB exchanges with a
fatty acid to regenerate the substrate for FakA.
- The system is widespread in Gram-positive bacteria, with most strains
possessing a single FakA protein along with multiple FakB subunits
that differ in their specificity toward fatty acid substrates.
|
| Cross-references |
|---|
| BRENDA | 2.7.2.18 |
| EC2PDB | 2.7.2.18 |
| ExplorEnz | 2.7.2.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.2.18 |
| IUBMB Enzyme Nomenclature | 2.7.2.18 |
| MEDLINE | Find literature relating to 2.7.2.18 |
| MetaCyc | 2.7.2.18 |
| Rhea expert-curated reactions | 2.7.2.18 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.7.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-
